Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

scientific article

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NM.2402
P932PMC publication ID3169724
P698PubMed publication ID21822287
P5875ResearchGate publication ID51552741

P50authorGordon B. MillsQ28086262
Nathanael GrayQ28112823
John MonahanQ58880941
Rameen BeroukhimQ88043871
P2093author name stringJean J Zhao
Fan Zhang
Changzhong Chen
Edward A Fox
Robert Schlegel
Maria Raeder
Hailing Cheng
Pixu Liu
Janet Yang
Stephanie Santiago
Adam Isabella
Derek J Semaan
P2860cites workGene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathwayQ21135589
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenicQ27824826
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancersQ27851457
High frequency of mutations of the PIK3CA gene in human cancersQ28131776
The transcriptional repressor Snail promotes mammary tumor recurrenceQ28272823
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screenQ29615061
PI3K pathway alterations in cancer: variations on a themeQ29615530
Targeting the phosphoinositide 3-kinase pathway in cancerQ29615809
Diverse somatic mutation patterns and pathway alterations in human cancersQ29619825
A novel doxycycline-inducible system for the transgenic analysis of mammary gland biologyQ34116752
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cellsQ34234737
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Q34307548
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanismsQ34625881
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.Q35204486
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.Q35757521
Cancer-specific mutations in phosphatidylinositol 3-kinaseQ36846595
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancerQ37187915
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941Q37281824
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical modelsQ39706127
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cellsQ40220260
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cellsQ40345016
Mutant PIK3CA promotes cell growth and invasion of human cancer cellsQ40410776
An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arraysQ40559185
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cellsQ40572608
Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasisQ44259982
Determination of subcutaneous tumor size in athymic (nude) miceQ46296687
High-resolution genomic and expression analyses of copy number alterations in breast tumorsQ80856831
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1116-1120
P577publication date2011-08-07
P1433published inNature MedicineQ1633234
P1476titleOncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
P478volume17