New metal complexes as potential therapeutics

scientific article

New metal complexes as potential therapeutics is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1367-5931(03)00081-4
P698PubMed publication ID12941423

P2093author name stringStephen J Lippard
Christiana Xin Zhang
P2860cites workTherapeutic radiopharmaceuticalsQ28212219
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In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancerQ37352731
p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cellsQ37385633
Different recognition of DNA modified by aatitumor cisplatin and its clinically ineffective trans isomer by tumor suppressor protein p53.Q38302471
Antitumor activity of the mixed phosphine gold species chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I).Q40654861
Testis-specific HMG-domain protein alters the responses of cells to cisplatinQ40711026
The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathwayQ40715456
Hypotensive properties and acute toxicity of trans-[Ru(NH(3))(4)P(OEt)(3)(NO)](PF(6))(3), a new nitric oxide donorQ40732264
Mechanistic studies on AMD6221: a ruthenium-based nitric oxide scavengerQ40743483
Inhibition of cancer cell growth by ruthenium(II) arene complexesQ40774119
High-throughput synthesis and screening of platinum drug candidatesQ40835835
Gold(III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold(III) compoundsQ40853299
Antitumor properties of some 2-[(dimethylamino)methyl]phenylgold(III) complexesQ41144493
In vivo effects of the controlled NO donor/scavenger ruthenium cyclam complexes on blood pressureQ42526193
cis-Dichloroplatinum(II) complexes tethered to 9-aminoacridine-4-carboxamides: synthesis and action in resistant cell lines in vitro.Q43643253
Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.Q43653393
Estrogen-derived steroidal metal complexes: agents for cellular delivery of metal centers to estrogen receptor-positive cells.Q43683418
Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery systemQ43702217
Design of macromolecular prodrug of cisplatin using dextran with branched galactose units as targeting moieties to hepatoma cellsQ43800374
Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophoreQ43812059
Mononuclear platinum(II) complex with 2-phenylpyridine ligands showing high cytotoxicity against mouse sarcoma 180 cells acquiring high cisplatin resistance.Q43821272
Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells.Q43922040
Gold(III) complexes with bipyridyl ligands: solution chemistry, cytotoxicity, and DNA binding propertiesQ43946320
Binding to cisplatin-modified DNA by the Saccharomyces cerevisiae HMGB protein Nhp6A.Q43968612
Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activityQ43977115
Soluble tetraarylporphyrin-platinum conjugates as cytotoxic and phototoxic antitumor agentsQ43977118
The interaction of DNA-targeted 9-aminoacridine-4-carboxamide platinum complexes with DNA in intact human cells.Q43984243
Topoisomerase II antagonism and anticancer activity of coordinated derivatives of [RuCl(2)(C(6)H(6))(dmso)].Q44020716
DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repairQ44133887
Cytotoxic acridinylthiourea and its platinum conjugate produce enzyme-mediated DNA strand breaksQ44148584
The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiaeQ44187748
Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines.Q44215847
Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.Q44244866
Ruthenium(III) polyaminocarboxylate complexes: efficient and effective nitric oxide scavengersQ44363334
In vitro and in vivo antitumor properties of tetrakis((trishydroxy- methyl)phosphine)gold(I) chloride.Q44368091
Cholic acid-carboplatin compounds (CarboChAPt) as models for specific drug delivery: synthesis of novel carboplatin analogous derivatives and comparison of the cytotoxic properties with corresponding cisplatin compoundsQ44384840
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell linesQ44446747
Metal complexes as enzyme inhibitorsQ46308676
Nucleotide excision repair from site-specifically platinum-modified nucleosomes.Q51836720
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.Q55035583
Current status of trans-platinum compounds in cancer therapyQ59172903
Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair of DNA intrastrand cross-links of novel antitumor trinuclear platinum complex BBR3464Q73752006
Medicinal inorganic chemistry: introductionQ77367161
Metal complexes as photo- and radiosensitizersQ77367176
Treatment of Wilson and menkes diseasesQ77367188
Functional mimics of superoxide dismutase enzymes as therapeutic agentsQ77367198
P433issue4
P304page(s)481-489
P577publication date2003-08-01
P1433published inCurrent Opinion in Chemical BiologyQ15758415
P1476titleNew metal complexes as potential therapeutics
P478volume7

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Q36854716Synthesis, structures, and electrochemistry of gold(III) ethylenediamine complexes and interactions with guanosine 5'-monophosphate
Q39775092Tautomeric forms study of 1H-(2'-pyridyl)-3-methyl-5-hydroxypyrazole and 1H-(2'-pyridyl)-3-phenyl-5-hydroxypyrazole. Synthesis, structure, and cytotoxic activity of their complexes with palladium(II) ions
Q39400527The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials
Q38880669The gold (III) porphyrin complex, gold-2a, suppresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1.
Q51040701The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach.
Q26999667The path for metal complexes to a DNA target
Q39111089The relationship between electrospray ionization behavior and cytotoxic activity of [M(I)(P)4](+)-type complexes (M = Cu, Ag and Au; P = tertiary phosphine).
Q40003392Towards the rational design of platinum(II) and gold(III) complexes as antitumour agents.
Q40089378Trans-platinum(II) complexes with cyclohexylamine as expectator ligand induce necrosis in tumour cells by inhibiting DNA synthesis and RNA transcription.
Q40484991Transfer of Copper from an Amyloid to a Natural Copper-Carrier Peptide with a Specific Mediating Ligand.
Q33640724Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity
Q37670137Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
Q35040088Tumor-targeting novel manganese complex induces ROS-mediated apoptotic and autophagic cancer cell death
Q37855894Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success?
Q46679681Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates.
Q37226453Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells
Q39184979Zinc(II) complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers that trigger DNA damage-mediated p53 phosphorylation in cancer cells.
Q92681136trans-Platinum(II) Thionate Complexes: Synthesis, Structural Characterization, and in vitro Biological Assessment as Potent Anticancer Agents

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