CNS regeneration: clinical possibility or basic science fantasy?

scientific article

CNS regeneration: clinical possibility or basic science fantasy? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0967-5868(03)00004-3
P698PubMed publication ID12948453

P50authorDavid HowellsQ45279396
P2093author name stringPeter E Batchelor
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Nogo domains and a Nogo receptor: implications for axon regenerationQ34245267
Restoration of function by replacement of spinal cord segments in the rat.Q48190443
Adrenal medulla grafts enhance recovery of striatal dopaminergic fibersQ48219303
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Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesionsQ48242887
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Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissueQ48313494
Regeneration of brainstem-spinal axons after lesion and immunological disruption of myelin in adult rat.Q48316154
Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.Q48423326
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Specialized neuroglial arrangement may explain the capacity of vomeronasal axons to reinnervate central neuronsQ48555998
BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regenerationQ48567818
Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cellsQ48626271
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Intrahippocampal septal grafts ameliorate learning impairments in aged ratsQ48635415
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Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's diseaseQ48671006
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Septal transplants restore maze learning in rats with fornix-fimbria lesionsQ48872370
Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblastsQ48879905
Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion siteQ48909503
Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease?Q48956588
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Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.Q51451500
Restoration of cognitive abilities by cholinergic grafts in cortex of monkeys with lesions of the basal nucleus of Meynert.Q52212516
GAP-43 in the axons of mammalian CNS neurons regenerating into peripheral nerve grafts.Q52238815
Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease.Q54137161
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Recovery of function after spinal cord injury: mechanisms underlying transplant-mediated recovery of function differ after spinal cord injury in newborn and adult rats.Q54494334
Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats.Q55067631
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Axons from CNS neurones regenerate into PNS graftsQ59054929
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Transplanted dopaminergic neurons: more or less?Q43592474
Treatment of stroke in rat with intracarotid administration of marrow stromal cellsQ43653449
Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitorsQ43654834
Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat.Q43718116
Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins.Q43805370
Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cordQ43880608
Periwound dopaminergic sprouting is dependent on numbers of wound macrophagesQ43925260
Restoration of learning ability in fornix-transected monkeys after fetal basal forebrain but not fetal hippocampal tissue transplantationQ43930423
Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions.Q43972746
Cholinergic neural transplants into hippocampus restore learning ability in monkeys with fornix transectionsQ44360774
Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neuronsQ44536901
Intracerebral grafting of cultured autologous skin fibroblasts into the rat striatum: an assessment of graft size and ultrastructureQ44625503
Bulbospinal and intraspinal connections in normal and regenerated salamander spinal cordQ45215414
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Adrenal to caudate transplantation--postmortem study.Q45960945
Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injuryQ46096843
Sprouting adult CNS cholinergic axons express NILE and associate with astrocytic surfaces expressing neural cell adhesion moleculeQ46138917
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury.Q46187210
Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cordQ46242173
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Effects of silica on the outcome from experimental spinal cord injury: implication of macrophages in secondary tissue damageQ46779870
A quantifiable model of axonal regeneration in the demyelinated adult rat spinal cordQ47968569
Sprouting of dopaminergic axons after striatal injury: confirmation by markers not dependent on dopamine metabolism.Q48100859
Decorin attenuates gliotic scar formation in the rat cerebral hemisphereQ48100902
Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matterQ48105976
Four-year follow-up of adrenal-to-brain transplants in Parkinson's diseaseQ48108676
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Long interfascicular axon growth from embryonic neurons transplanted into adult myelinated tractsQ48163523
Regrowth of dorsal root axons into a radiation-induced glial-deficient environment in the spinal cordQ48190356
Retraining the injured spinal cordQ34249895
The astrocyte/meningeal cell interface--a barrier to successful nerve regeneration?Q34361841
Spinal cord repair in adult paraplegic rats: partial restoration of hind limb functionQ34384227
Spinal cord regeneration: from gene to transplantsQ34503144
Channeling of developing rat corticospinal tract axons by myelin-associated neurite growth inhibitorsQ34571987
Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injuryQ34745372
Intrinsic neuronal determinants of regenerationQ35318056
Preferential outgrowth of central nervous system neurites on astrocytes and Schwann cells as compared with nonglial cells in vitroQ36211676
Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreadingQ36218407
B-50 (GAP-43) immunoreactivity is rarely detected within intact catecholaminergic and serotonergic axons innervating the brain and spinal cord of the adult rat, but is associated with these axons following lesionQ36679398
Axonal regeneration and limited functional recovery following hippocampal deafferentationQ36824491
Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cordQ36898625
Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injuryQ36913140
Boundaries and wounds, glia and glycoconjugates. Cellular and molecular analyses of developmental partitions and adult brain lesionsQ36951467
Intraspinal transplantsQ37685736
Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat.Q38523590
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.Q38524950
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's diseaseQ39111166
Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's diseaseQ39116027
Long-term evaluation of bilateral fetal nigral transplantation in Parkinson diseaseQ39116966
Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous systemQ39794558
Neural injury repair: hope for the future as barriers to effective CNS regeneration become clearerQ40404596
Fibroblast growth factors in the nervous systemQ40590939
Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy.Q40649831
Inhibition of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression reduces dopaminergic sprouting in the injured striatum.Q40849460
Neuronal cell transplantation for Parkinson's and Huntington's diseasesQ40909110
Degeneration and regeneration of axons in the lesioned spinal cordQ40980911
Mechanisms of functional recovery and regeneration after spinal cord transection in larval sea lampreyQ41039876
Regeneration of immature mammalian spinal cord after injury.Q41077554
Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatumQ41087517
Adrenal medullary autografts into the basal ganglia of Cebus monkeys: injury-induced regeneration.Q41347673
Fetal nigral transplantation as a therapy for Parkinson's diseaseQ41367101
Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recoveryQ41450648
Observations on the astrocyte response to a cerebral stab wound in adult ratsQ41496986
Neural transplantation studies reveal the brain's capacity for continuous reconstruction.Q41623996
Elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regenerationQ41713434
Axon sprouting into segments of rat spinal cord adjacent to the site of a previous transectionQ41752632
The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brainQ41945091
Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouseQ42448123
Basal membrane-depleted scar in lesioned CNS: characteristics and relationships with regenerating axonsQ42475672
Axon-glial relations during regeneration of axons in the adult rat anterior medullary velumQ42483199
Autopsy findings in a patient who had an adrenal-to-brain transplant for Parkinson's diseaseQ42505132
Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerveQ42519727
Induction of a neurite-promoting factor in rat brain following injury or deafferentationQ42525546
Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injuryQ42606175
Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro.Q42803404
Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS.Q42819573
Effects of spinal cord X-irradiation on the recovery of paraplegic ratsQ43550148
Regenerating descending axons preferentially reroute to the gray matter in the presence of a general macrophage/microglial reaction caudal to a spinal transection in adult zebrafishQ64468042
Recollections of research in spinal cord regenerationQ67255771
Relationship between residual hindlimb-assisted locomotion and surviving axons after incomplete spinal cord injuriesQ67599644
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytesQ67703308
Growth of adult rat retinal ganglion cell neurites on astrocytesQ68427380
Macrophages can modify the nonpermissive nature of the adult mammalian central nervous systemQ68543538
Regrowth of lesioned dorsal root nerve fibers into the spinal cord of neonatal ratsQ68945795
Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowthQ69059869
Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of Parkinson's diseaseQ69096564
Tissue sections from the mature rat brain and spinal cord as substrates for neurite outgrowth in vitro: extensive growth on gray matter but little growth on white matterQ69963050
Deposition of scar tissue in the central nervous systemQ70925683
Histopathological reactions and axonal regeneration in the transected spinal cord of hibernating squirrelsQ71006910
Traumatized rat striatum produces neurite-promoting and neurotrophic activities in vitroQ71130283
Transplantation of activated macrophages overcomes central nervous system regrowth failureQ71604041
Regeneration of dorsal root axons into experimentally altered glial environments in the rat spinal cordQ71650065
Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic miceQ71806446
Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scarsQ71815667
Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowthQ71939823
Sprouts from Cut Corticospinal Axons Persist in the Presence of Astrocytic Scarring in Long-Term Lesions of the Adult Rat Spinal CordQ72052012
Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cordQ72052105
Paraventriculospinal tract as a model for axon injury: spinal cordQ72556851
GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the ratQ72557616
Astroglial reaction in the gray matter lumbar segments after midthoracic transection of the adult rat spinal cordQ72641223
Reversal of hemiparkinsonian syndrome in nonhuman primates by amnion implantation into caudate nucleusQ72816680
Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cordQ73189218
Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cordQ73226161
Stem cells. Rat spinal cord function partially restoredQ73301234
Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantationQ73343119
What is a functional recovery after spinal cord injury?Q73606422
Regeneration of severed nerve fibers in the spinal cord of the adult catQ73724144
Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injuryQ73735755
Regeneration of spinal cord fibers in the catQ73795160
Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spinal cordQ74000060
Regeneration of axons in the vertebrate central nervous systemQ74267769
Regeneration in the spinal cord of the cat and dogQ75539726
Absence of regeneration in the spinal cord of the young ratQ75832779
Induction of type IV collagen and other basement-membrane-associated proteins after spinal cord injury of the adult rat may participate in formation of the glial scarQ77435842
Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cordQ78003481
Residual function after subtotal spinal cord transection in adult catsQ78291298
Lack of regeneration in spinal cord of ratQ80682223
Abortive regeneration of the transected spinal cordQ83275346
Dorsal roots following anastomosis of the central stumpsQ83287545
P433issue5
P304page(s)523-534
P577publication date2003-09-01
P1433published inJournal of Clinical NeuroscienceQ6294963
P1476titleCNS regeneration: clinical possibility or basic science fantasy?
P478volume10

Reverse relations

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