Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

scientific article

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2011.01402.X
P932PMC publication ID3171858
P698PubMed publication ID21470200
P5875ResearchGate publication ID229953801

P50authorHolly R. YeatmanQ56112026
Jessica K HolienQ82218645
Philip E. ThompsonQ38804514
Michael W ParkerQ41147578
P2093author name stringAnthony L Albiston
Siew Yeen Chai
Broden Morgan
Ruani N Fernando
Shanti Diwakarla
Simon J Mountford
Vi Pham
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Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesiclesQ28569814
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Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IVQ28573288
Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathwayQ28575179
Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous systemQ28579048
The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitroQ28579223
Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasisQ28589946
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Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP.Q30444206
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Therapeutic targeting of insulin-regulated aminopeptidase: heads and tails?Q33300628
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Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice.Q37569132
Participation of D 1-4 dopamine receptors in the pro-cognitive effects of angiotensin IV and des-Phe 6 angiotensin IV.Q37581159
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Immune proteins in brain development and synaptic plasticity.Q37617631
Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture.Q38320374
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Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP).Q39636315
Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidaseQ39680651
Beta-homo-amino acid scan of angiotensin IV.Q39995293
Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor.Q40122056
Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neuronsQ40132721
Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase.Q40768845
Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats.Q42599380
The amino terminus of insulin-responsive aminopeptidase causes Glut4 translocation in 3T3-L1 adipocytesQ42795999
Insulin stimulates cell surface aminopeptidase activity toward vasopressin in adipocytesQ42802101
Intrahippocampal Norleucine¹-Angiotensin IV mitigates scopolamine-induced spatial working memory deficitsQ42917818
The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analoguesQ43275899
Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memoryQ43297455
Angiotensin IV enhances LTP in rat dentate gyrus in vivoQ43713596
A role for the angiotensin AT4 receptor subtype in overcoming scopolamine-induced spatial memory deficitsQ43814000
Ethanol-induced suppression of LTP can be attenuated with an angiotensin IV analogQ44397760
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).Q44518988
Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficitsQ44828738
Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigmsQ45012094
The circulating vasopressinase of pregnancy: Species comparison with radioimmunoassayQ45905091
The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?Q46430078
Regulation of class I MHC gene expression in the developing and mature CNS by neural activityQ46490752
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.Q46503099
Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2.Q46538139
Effect of D(3) dopamine receptors blockade on the cognitive effects of angiotensin IV in rats.Q46688100
Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learningQ48218315
Angiotensin II(3-8) (ANG IV) hippocampal binding: potential role in the facilitation of memoryQ48381985
The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brainQ48701785
The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memoryQ48822233
Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in ratsQ48934009
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Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase.Q51950733
Glucose attenuation of memory impairments.Q52026760
Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats.Q52048507
Attenuation of scopolamine-induced spatial learning impairments by an angiotensin IV analog.Q52185174
Functional evidence for an angiotensin IV receptor in rat resistance arteries.Q54075062
Analysis of responses to angiotensin IV in the pulmonary vascular bed of the cat.Q54197564
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)37-47
P577publication date2011-09-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleIdentification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers
P478volume164

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