Physiological effects of microgravity on osteoblast morphology and cell biology

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Physiological effects of microgravity on osteoblast morphology and cell biology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1569-2574(02)08017-6
P698PubMed publication ID12951695

P50authorMillie Hughes-FulfordQ446243
P2860cites workRole of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape changeQ24313072
Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1Q28286233
The effect of microgravity on morphology and gene expression of osteoblasts in vitro.Q33648767
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Prolonged weightlessness and calcium loss in man.Q34117386
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Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma proteinQ36236717
Gravity effects on single cells: techniques, findings, and theoryQ36476314
Effects of microgravity on osteoblast growth activationQ36797092
Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tensionQ36921506
Altered cell function in microgravityQ37373582
Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.Q40300975
Effects of gravity on the cellular response to epidermal growth factorQ40529855
Cytosolic phospholipase A(2) activity during the ongoing cell cycleQ40789901
The effect of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF-7.Q40814057
The effect of hypogravity and hypergravity on cells of the immune systemQ40845679
Effects of orbital spaceflight on human osteoblastic cell physiology and gene expressionQ40893549
Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblastsQ40909534
Mechanotransduction and the functional response of bone to mechanical strainQ40947864
Transcriptional control of osteoblast growth and differentiationQ40980928
Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in boneQ41039780
Gene expression related to the differentiation of osteoblastic cells is altered by microgravityQ41040462
Effect of dexamethasone on proliferating osteoblasts: inhibition of prostaglandin E2 synthesis, DNA synthesis, and alterations in actin cytoskeletonQ41099575
Microgravity reduces the differentiation of human osteoblastic MG-63 cellsQ41113869
Cell sensitivity to gravityQ41596042
Spaceflight effects on cultured embryonic chick bone cellsQ42488834
Spaceflight inhibits bone formation independent of corticosteroid status in growing ratsQ42490565
Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein.Q42798461
Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cellsQ43589116
Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeletonQ43705432
Roentgenographic bone density changes in astronauts during representative Apollo space flightQ46284204
Hindlimb unloading of growing rats: a model for predicting skeletal changes during space flightQ46291801
Decreased mineralization and increased calcium release in isolated fetal mouse long bones under near weightlessness.Q46294605
Spaceflight modulates insulin-like growth factor binding proteins and glucocorticoid receptor in osteoblastsQ47875941
Signal transduction of mechanical stimuli is dependent on microfilament integrity: identification of osteopontin as a mechanically induced gene in osteoblasts.Q52192530
Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes.Q52235118
Inhibition of Bone Formation During Space FlightQ66841678
Inhibition of EGF-induced signal transduction by microgravity is independent of EGF receptor redistribution in the plasma membrane of human A431 cellsQ70578018
Mitogenic signal transduction in T lymphocytes in microgravityQ70735820
Shape changes of osteoblastic cells under gravitational variations during parabolic flight--relationship with PGE2 synthesisQ70952402
Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesisQ71151143
The biochemical pathway mediating the proliferative response of bone cells to a mechanical stimulusQ71556362
Effects of spaceflight and recovery on rat humeri and vertebrae: histological and cell culture studiesQ71583765
Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivoQ71773574
Microgravity induces prostaglandin E2 and interleukin-6 production in normal rat osteoblasts: role in bone demineralizationQ71954559
Cyclic stretching of human osteoblasts affects proliferation and metabolism: a new experimental method and its applicationQ72256509
Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substratesQ73028680
Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttleQ73031229
Demonstration of feasibility of automated osteoblastic line culture in space flightQ73063021
Prostaglandin E2 increases the skeletal response to mechanical loadingQ73090724
Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humansQ73402252
Expression of PDGF-beta receptor, EGF receptor, and receptor adaptor protein Shc in rat osteoblasts during spaceflightQ73518792
Culture in vector-averaged gravity under clinostat rotation results in apoptosis of osteoblastic ROS 17/2.8 cellsQ73632653
C-peptide and PGE2 activity during human spaceflightQ73758325
Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cellsQ73820571
cDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat)Q74299266
Effects of microgravity on c-fos gene expression in osteoblast-like MC3T3-E1 cellsQ74477574
Evaluation of a bone's in vivo 24-hour loading history for physical exercise compared with background loadingQ74493918
Gene expression in spaceQ77323548
Localisation of prostaglandin endoperoxide H synthase (PGHS)-1 and PGHS-2 in bone following mechanical loading in vivoQ77654292
Nuclear translocation of mitogen-activated protein kinase p42MAPK during the ongoing cell cycleQ78075189
Attenuation of the protein wasting associated with bed rest by branched-chain amino acidsQ78193546
P921main subjectmicrogravityQ48655
osteoblastQ917177
P304page(s)129-157
P577publication date2002-01-01
P1433published inAdvances in space biology and medicineQ27710163
P1476titlePhysiological effects of microgravity on osteoblast morphology and cell biology
P478volume8

Reverse relations

cites work (P2860)
Q34206136Bone turnover in wild type and pleiotrophin-transgenic mice housed for three months in the International Space Station (ISS)
Q58700356Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential
Q39628260Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells
Q92591114Gene Expression in Osteoblasts and Osteoclasts Under Microgravity Conditions: A Systematic Review
Q37318321Gene expression profiling of human epidermal keratinocytes in simulated microgravity and recovery cultures
Q38014842Mechanisms of gravitational sensitivity of osteogenic precursor cells.
Q34565487Microtubules viewed as molecular ant colonies
Q38947596Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition
Q34119354Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells.
Q30439342Reversal of the detrimental effects of simulated microgravity on human osteoblasts by modified low intensity pulsed ultrasound.
Q34312867RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity
Q50675793Sensitivity of stromal precursor cells of different commitment to simulated microgravity

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