Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

scientific article

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112.3475B
P356DOI10.1073/PNAS.1420233112
P932PMC publication ID4371953
P698PubMed publication ID25733891
P5875ResearchGate publication ID273156307

P50authorEddy ArnoldQ29840104
Jan BalzariniQ31332118
Anita R MaguireQ39657849
Jubi JohnQ50222211
Lieve NaesensQ50551503
Kalyan DasQ55948575
Johan Vande VoordeQ56167028
P2093author name stringMatthias Götte
Sergio E Martinez
Sandra Liekens
Wim Dehaen
Alan Ford
Youngju Kim
Sarah Keane
Marianne Ngure
Jean A Bernatchez
Niki Mullins
Nuala Maguire
P2860cites workMechanism of allosteric activation of SAMHD1 by dGTPQ24338757
Structures of thymidine kinase 1 of human and mycoplasmic originQ24558609
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptaseQ24629039
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsQ24682078
Synthesis of nucleoside phosphate and phosphonate prodrugsQ26865400
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanismQ27676835
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motionQ27685473
Properties of an affinity-column-purified human deoxycytidylate deaminaseQ28115366
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptaseQ28368030
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurineQ28378681
The structure and function of G-protein-coupled receptorsQ29616792
DNA polymerases: structural diversity and common mechanismsQ29619403
Ribonucleotide reductasesQ29620027
Enzyme regulatory site-directed drugs: study of the interactions of 5'-amino-2', 5'-dideoxythymidine (5'-AdThd) and thymidine triphosphate with thymidine kinase and the relationship to the stimulation of thymidine uptake by 5'-AdThd in 647V cellsQ34042345
Modulation of thymidine kinase activity: a biochemical strategy to enhance the activation of antineoplastic drugs.Q34060002
Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of actionQ35185934
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridineQ35358460
The G protein-coupled receptors: pharmacogenetics and diseaseQ36310854
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Q36949351
Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini reviewQ37764763
Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy.Q37969861
Biased ligands: pathway validation for novel GPCR therapeuticsQ38212279
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocationQ38307044
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivativesQ40672674
Gemcitabine: preclinical pharmacology and mechanisms of action.Q41189882
Ara-C: cellular and molecular pharmacologyQ41617108
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes.Q41728302
Design and synthesis of α-carboxy nucleoside phosphonate analogues and evaluation as HIV-1 reverse transcriptase-targeting agentsQ42176363
Nucleic acid polymerases use a general acid for nucleotidyl transferQ42239117
Regulation of the activation of fluorodeoxyuridine by substrate competition and feedback inhibition in 647V cellsQ43629171
Mode of action of phosphonoformate as an anti-herpes simplex virus agentQ45802413
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolutionQ46900260
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistanceQ47814140
Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosidesQ57241212
Regulation of deoxycytidine kinase by deoxycytidine and deoxycytidine 5' triphosphate in whole leukemia and tumor cellsQ74580847
Metal Activation of Enzymes in Nucleic Acid BiochemistryQ77646678
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3475-3480
P577publication date2015-03-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAlpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics
P478volume112

Reverse relations

cites work (P2860)
Q40748250Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.
Q39951181Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η.
Q37523020Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase
Q38514586Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates
Q40251943Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses
Q47613826Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors
Q39178488NMR structure of the HIV-1 reverse transcriptase thumb subdomain
Q36970906Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates
Q90654304Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1

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