New insights into the pathophysiology of multiple myeloma

scientific article

New insights into the pathophysiology of multiple myeloma is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(03)01195-1
P698PubMed publication ID12965277

P2093author name stringJohannes Drach
Sonja Seidl
Hannes Kaufmann
P2860cites workFrequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3Q28242697
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myelomaQ28646235
A molecular compendium of genes expressed in multiple myelomaQ31105650
Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patientsQ33891633
Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy.Q33952275
Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cellsQ34115598
Plasma cells: finding new light at the end of B cell developmentQ34450168
RANK ligand and osteoprotegerin in myeloma bone disease.Q34992857
Lymphoma- and leukemia-associated chromosomal translocations in healthy individualsQ35056472
Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myelomaQ35938169
Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone diseaseQ36169814
Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myelomaQ37148117
Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentationQ38297517
Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arraysQ38298600
Moving disease biology from the lab to the clinicQ40608454
Myeloid cell factor-1 is a critical survival factor for multiple myelomaQ40655990
Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistanceQ40695090
Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma.Q40797432
Multiple myeloma: almost all patients are cytogenetically abnormalQ41076697
The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applicationsQ43700541
Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talkQ43993650
Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.Q44291805
Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myelomaQ44950046
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.Q52546411
A molecular study of the t(4;14) in multiple myeloma.Q52861322
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosisQ57785902
Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myelomaQ58050885
Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone diseaseQ62003041
Deletions of chromosome 13q in monoclonal gammopathy of undetermined significanceQ73166114
Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique HéQ73396499
Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapyQ73586012
p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significanceQ74064420
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migrationQ74129743
Hypodiploidy is a major prognostic factor in multiple myelomaQ74541841
Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapyQ74605768
Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survivalQ74673995
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environmentQ77337113
Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factorQ78409825
Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variantsQ78410075
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expressionQ78410148
Delineation of the minimal region of loss at 13q14 in multiple myelomaQ78600352
P433issue9
P921main subjectpathophysiologyQ1135939
P304page(s)557-564
P577publication date2003-09-01
P1433published inLancet Oncology CommissionQ13747613
P1476titleNew insights into the pathophysiology of multiple myeloma
P478volume4

Reverse relations

cites work (P2860)
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Q35681304c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions

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