Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification

scientific article

Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1128/MMBR.67.3.454-472.2003
P932PMC publication ID193871
P698PubMed publication ID12966144
P5875ResearchGate publication ID10574451

P50authorPaul N. BlackQ56155401
P2093author name stringConcetta C DiRusso
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CD36 mediates long-chain fatty acid transport in human myocardium: complete myocardial accumulation defect of radiolabeled long-chain fatty acid analog in subjects with CD36 deficiencyQ77759470
Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulinQ78239684
The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiaeQ24562152
Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding foldQ24598272
A family of fatty acid transporters conserved from mycobacterium to manQ24681246
The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadRQ27631126
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymesQ27733370
Identification of a yeast peroxisomal member of the family of AMP-binding proteinsQ27930506
Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex.Q27931109
The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levelsQ27931864
Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrationsQ27932646
Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acidsQ27934119
The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular Utilization.Q27935413
Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolismQ27935563
Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains.Q27937668
Biochemical studies of three Saccharomyces cerevisiae acyl-CoA synthetases, Faa1p, Faa2p, and Faa3pQ27938989
Identification of the major intestinal fatty acid transport proteinQ28145772
The kamikaze approach to membrane transportQ28210636
Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteriaQ28247508
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Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetaseQ28585960
Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36Q28678368
Molecular basis of bacterial outer membrane permeabilityQ29617897
The amino-terminal region of the long-chain fatty acid transport protein FadL contains an externally exposed domain required for bacteriophage T2 binding.Q30168966
Porins and specific channels of bacterial outer membranesQ30195509
The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locusQ30671157
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Long-chain fatty acid transport in bacteria and yeast. Paradigms for defining the mechanism underlying this protein-mediated processQ33637200
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Transport of fatty acids across membranes by the diffusion mechanism.Q33724950
How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?Q33783971
Long-chain acyl-CoA-dependent regulation of gene expression in bacteria, yeast and mammals.Q33866076
Cardiac fatty acid uptake and transport in health and diseaseQ33869970
Regulation of fatty acid transporters in mammalian cellsQ33870610
3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptakeQ33875742
Cellular uptake of long-chain fatty acids: role of membrane-associated fatty-acid-binding/transport proteinsQ33925295
Fatty acid competition as a mechanism by which Enterobacter cloacae suppresses Pythium ultimum sporangium germination and damping-offQ33988282
Thermodynamics of fatty acid transferQ33991454
Characterization of a heart-specific fatty acid transport proteinQ34173725
Bacterial periplasmic transport systems: structure, mechanism, and evolutionQ34182351
Fatty acid transport proteins: a current view of a growing familyQ34303655
Role of CD36 in membrane transport and utilization of long-chain fatty acids by different tissuesQ34322431
Involvement of membrane-associated proteins in the acute regulation of cellular fatty acid uptakeQ34322435
Expression cloning and characterization of a novel adipocyte long chain fatty acid transport proteinQ34325172
Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein.Q34455493
Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae.Q34507873
Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranesQ34538646
Fatty acid transport across membranes: relevance to nutrition and metabolic pathologyQ34676034
Antibiotic-based selection for bacterial genes that are specifically induced during infection of a hostQ34714854
Transport Proteins in Bacteria: Common Themes in Their DesignQ35150311
DNA sequence analysis and restriction fragment length polymorphisms of the P1 gene of Haemophilus influenzae biogroup aegyptius associated with Brazilian purpuric fever.Q35517464
Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein.Q35607048
Role of the Escherichia coli FadR regulator in stasis survival and growth phase-dependent expression of the uspA, fad, and fab genesQ35616465
Use of transposon TnphoA to identify genes for cell envelope proteins of Escherichia coli required for long-chain fatty acid transport: the periplasmic protein Tsp potentiates long-chain fatty acid transport.Q35979958
Primary sequence of the Escherichia coli fadL gene encoding an outer membrane protein required for long-chain fatty acid transportQ36125332
Physical map location of the Escherichia coli gene encoding acyl coenzyme A synthetaseQ36137376
Isolation of a Saccharomyces cerevisiae long chain fatty acyl:CoA synthetase gene (FAA1) and assessment of its role in protein N-myristoylation.Q36531289
Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptorsQ36713875
pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acidsQ37320910
Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiationQ37545829
Transport of long-chain fatty acids by Escherichia coli: mapping and characterization of mutants in the fadL geneQ37590812
Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranesQ37672034
Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human: Traffic ATPasesQ37862758
Evidence that His110 of the protein FadL in the outer membrane of Escherichia coli is involved in the binding and uptake of long-chain fatty acids: possible role of this residue in carboxylate binding.Q38292125
Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.Q38320251
Regulation of transcription of genes required for fatty acid transport and unsaturated fatty acid biosynthesis in Escherichia coli by FadR.Q38322704
Fatty acyl-CoA binding domain of the transcription factor FadR. Characterization by deletion, affinity labeling, and isothermal titration calorimetryQ38330794
Fatty Acid Activation: Specificity, Localization, and FunctionQ39085660
Multiple factors independently regulate hilA and invasion gene expression in Salmonella enterica serovar typhimuriumQ39538569
The fadL gene product of Escherichia coli is an outer membrane protein required for uptake of long-chain fatty acids and involved in sensitivity to bacteriophage T2.Q39953526
Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coliQ40800767
Molecular aspects of fatty acid transport: mutations in the IYTSGTTGXPK motif impair fatty acid transport protein functionQ40931687
How do long-chain free fatty acids cross cell membranes?Q40980871
Kinetics of the utilization of medium and long chain fatty acids by mutant of Escherichia coli defective in the fadL geneQ41097044
Regulation of FAT/CD36 gene expression: further evidence in support of a role of the protein in fatty acid binding/transportQ41101487
Fatty acid uptake by Caco-2 human intestinal cellsQ41230435
The fats of Escherichia coli during infancy and old age: regulation by global regulators, alarmones and lipid intermediates.Q41702345
Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placentaQ42459652
Energetics underlying the process of long-chain fatty acid transportQ42472111
Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytesQ42520490
Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane.Q42816411
Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transportQ42825339
Membrane topology of the murine fatty acid transport protein 1.Q42826967
Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adipocytes mediates saturable fatty acid uptakeQ42829501
Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophyQ43589173
Functional role of fatty acyl-coenzyme A synthetase in the transmembrane movement and activation of exogenous long-chain fatty acids. Amino acid residues within the ATP/AMP signature motif of Escherichia coli FadD are required for enzyme activity anQ44009258
Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1pQ44019901
Hepatocellular fatty acid uptake is mediated by a plasma membrane fatty acid binding protein closely related to mitochondrial glutamic oxaloacetic transaminaseQ45752916
Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limitingQ46042153
Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acidsQ47712164
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific mannerQ47921885
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.Q47992709
Genetic analysis of the role of Saccharomyces cerevisiae acyl-CoA synthetase genes in regulating protein N-myristoylationQ48081012
Evidence for a hepatocyte membrane fatty acid transport protein using rat liver mRNA expression in Xenopus laevis oocytes.Q49056643
Complementation of Saccharomyces cerevisiae strains containing fatty acid activation gene (FAA) deletions with a mammalian acyl-CoA synthetaseQ49165140
A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.Q51562671
The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetaseQ52159617
Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers.Q52389230
Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae.Q52521097
Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice.Q52548604
Affinity labeling fatty acyl-CoA synthetase with 9-p-azidophenoxy nonanoic acid and the identification of the fatty acid-binding site.Q52582749
Fatty acid degradation in Escherichia coli. An inducible acyl-CoA synthetase, the mapping of old-mutations, and the isolation of regulatory mutantsQ53794593
Mutational analysis of a fatty acyl-coenzyme A synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity.Q54570547
Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases.Q54619057
Bacterial long-chain fatty acid transport. Identification of amino acid residues within the outer membrane protein FadL required for activity.Q54654289
Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AQ54680260
Characterization of FadL-specific fatty acid binding in Escherichia coli.Q54709739
Isolation and characterization of the multiple charge isoforms of acyl-CoA synthetase from Escherichia coli.Q54789041
Rapid Flip-flop of Oleic Acid across the Plasma Membrane of AdipocytesQ60564083
Transport of long and medium chain fatty acids by Escherichia coli K12Q67290588
Linker mutagenesis of a bacterial fatty acid transport protein. Identification of domains with functional importanceQ68179776
Partial purification and characterization of fatty acid binding protein(s) in Escherichia coli membranes and reconstitution of fatty acid transport systemQ68907312
A physical-chemical model for cellular uptake of fatty acids: prediction of intracellular pool sizesQ69441363
Selective inhibition of long-chain fatty acid uptake in short-term cultured rat hepatocytes by an antibody to the rat liver plasma membrane fatty acid-binding proteinQ69540480
Long-chain fatty acid transport in Escherichia coli. Cloning, mapping, and expression of the fadL geneQ69881813
Purification and characterization of acyl coenzyme A synthetase from Escherichia coliQ70153845
Purification and characterization of an outer membrane-bound protein involved in long-chain fatty acid transport in Escherichia coliQ70161679
Transport of fatty acid is obligatory coupled with H+ entry in spheroplasts of Escherichia coli K12Q70178112
Mechanism of long chain fatty acid permeation in the isolated adipocyteQ70875587
Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane proteinQ71430966
Determination of the chemical pathway for 4-chlorobenzoate:coenzyme A ligase catalysisQ71691362
Fatty acid flip-flop in phospholipid bilayers is extremely fastQ71715270
Fatty acid uptake in Escherichia coli: regulation by recruitment of fatty acyl-CoA synthetase to the plasma membraneQ72826086
Long chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophilsQ72863661
Is CD36 deficiency an etiology of hereditary hypertrophic cardiomyopathy?Q73088306
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
fatty acidQ61476
P304page(s)454-72, table of contents
P577publication date2003-09-01
P1433published inMicrobiology and Molecular Biology ReviewsQ6839270
P1476titleTransmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification
P478volume67

Reverse relations

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