A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation

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A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2003PNAS..100.9208M
P356DOI10.1073/PNAS.1633590100
P932PMC publication ID170897
P698PubMed publication ID12883009
P5875ResearchGate publication ID6476765

P50authorFerid MuradQ295999
P2093author name stringEmil Martin
Iraida Sharina
Alexander Kots
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Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclaseQ30427519
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Biological sensors: More than one way to sense oxygenQ33652937
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YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent componentsQ33948966
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Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclaseQ35124292
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Human recombinant soluble guanylyl cyclase: expression, purification, and regulationQ37259340
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamineQ39140610
Localization of particulate guanylate cyclase in plasma membranes and microsomes of rat liverQ40326706
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.Q40735472
Nitric oxide activates the beta 2 subunit of soluble guanylyl cyclase in the absence of a second subunitQ40799534
Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?Q40840121
Heme ligand replacement reactions of cytochrome P-450. Characterization of the bonding atom of the axial ligand trans to thiolate as oxygenQ42263374
Expression of soluble guanylate cyclase activity requires both enzyme subunitsQ42464263
Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotidesQ43417658
Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic methodQ43913799
Dissociation of nitric oxide from soluble guanylate cyclaseQ46951812
Soluble guanylyl cyclase: structure and regulation.Q52980737
A functional heme-binding site of soluble guanylyl cyclase requires intact N-termini of alpha 1 and beta 1 subunits.Q53005214
Soluble guanylate cyclase purified from bovine lung contains heme and copperQ55062277
Soluble guanylate cyclase from rat lung exists as a heterodimerQ69881953
Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxideQ70930193
Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with Resonance raman spectroscopyQ71087376
Probing the heme iron coordination structure of pressure-induced cytochrome P420camQ71807829
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-hemeQ72539436
Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclaseQ72566480
Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric statesQ72677054
Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450, chloroperoxidase, and catalaseQ72940389
A point-mutated guanylyl cyclase with features of the YC-1-stimulated enzyme: implications for the YC-1 binding site?Q73187839
Effects of GTP on bound nitric oxide of soluble guanylate cyclase probed by resonance Raman spectroscopyQ73581647
Interaction of soluble guanylate cyclase with YC-1: kinetic and resonance Raman studiesQ73626067
Mechanism of YC-1-induced activation of soluble guanylyl cyclaseQ74095219
Identification of two important heme site residues (cysteine 75 and histidine 77) in CooA, the CO-sensing transcription factor of Rhodospirillum rubrumQ74533392
P433issue16
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)9208-9213
P577publication date2003-07-25
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation
P478volume100

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cites work (P2860)
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