The role of plasminogen activators in the regulation of connective tissue metalloproteinases

scientific article published on December 4, 1992

The role of plasminogen activators in the regulation of connective tissue metalloproteinases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1749-6632.1992.TB51590.X
P8608Fatcat IDrelease_s4kjmofpvbg7leixduvel6idde
P698PubMed publication ID1339240

P50authorJelena GavrilovicQ57160155
P2093author name stringG. Murphy
J. J. Reynolds
R. Ward
S. Atkinson
P2860cites workMembrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis.Q38190315
Cell-associated plasminogen activation: regulation and physiological functionsQ39607376
Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activationQ40096626
Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cellsQ41514749
Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).Q41678253
The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.Q41770633
Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activitiesQ41856078
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymesQ41866734
Comparison of human stromelysin and collagenase by cloning and sequence analysisQ42128842
Degradation of type I collagen films by mouse osteoblasts is stimulated by 1,25 dihydroxyvitamin D3 and inhibited by human recombinant TIMP (tissue inhibitor of metalloproteinases).Q43568432
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic propertiesQ28268723
Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)Q28618144
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetateQ28618372
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family membersQ34453431
The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseasesQ35301529
In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.Q36220034
Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating systemQ36223446
Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitroQ36223450
Isolation of a nonmitogenic angiogenesis factor from wound fluidQ36326908
Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activationQ37666731
P407language of work or nameEnglishQ1860
P921main subjectconnective tissueQ25615
plasminogenQ107129060
P304page(s)1-12
P577publication date1992-12-01
1992-12-04
P1433published inAnnals of the New York Academy of SciencesQ2431664
P1476titleThe role of plasminogen activators in the regulation of connective tissue metalloproteinases
P478volume667

Reverse relations

cites work (P2860)
Q39975026A hybrid protein comprising ATF domain of pro-UK and VAS, an angiogenesis inhibitor, is a potent candidate for targeted cancer therapy
Q40771328A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in human glioma invasion
Q28589602A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
Q22011054A urokinase receptor-associated protein with specific collagen binding properties
Q47697374Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.
Q28373795Acetaldehyde increases the activity and gene expression of urokinase type plasminogen activator in a hepatic stellate cell line
Q33615455Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction
Q33749766Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.
Q28287089Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D
Q33876789Adhesion formation after laparoscopic surgery: what do we know about the role of the peritoneal environment?
Q48033529Binding of latent matrix metalloproteinase 9 to fibrin: activation via a plasmin-dependent pathway
Q37495418Biomarkers of AAA progression. Part 1: extracellular matrix degeneration
Q38055477Cell surface remodeling by plasmin: a new function for an old enzyme
Q42004427Cell-mediated degradation of type IV collagen and gelatin films is dependent on the activation of matrix metalloproteinases
Q71657591Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall
Q44508110Collagen type I, III and V differently modulate synthesis and activation of matrix metalloproteinases by cultured rabbit periosteal fibroblasts.
Q41481774Collagenase: a key enzyme in collagen turnover
Q74531892Complex alterations in gene expression occur in the knee ligaments of the skeletally mature multiparous rabbit during pregnancy
Q40598423Connective tissue degradation in health and periodontal disease and the roles of matrix metalloproteinases and their natural inhibitors
Q33886514Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants.
Q37949685Copper-induced hepatitis: the COMMD1 deficient dog as a translational animal model for human chronic hepatitis
Q78804814Decreased plasminogen activator inhibitor-1 secretion in hypoxic corneal epithelial cells is associated with increased urokinase plasminogen activator activity
Q42808161Dilong: role in peripheral nerve regeneration
Q38296528Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes.
Q40874441Downregulation of the urokinase-type plasminogen activator receptor through inhibition of translation by antisense oligonucleotide suppresses invasion of human glioblastoma cells
Q35423717Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid
Q45712502Effect of malondialdehyde-acetaldehyde-protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells
Q41185529Eicosanoids, fatty acids and restenosis following coronary artery bypass graft surgery and balloon angioplasty
Q54420587Elevated levels of plasminogen-activator inhibitor type 1 in atherosclerotic aorta.
Q73025879Elevations of tissue-type plasminogen activator and differential expression of urokinase-type plasminogen activator in diseased aorta
Q91598075Evaluation of Plasma Urokinase-Type Plasminogen Activator Receptor (UPAR) in Patients With Chronic Hepatitis B, C and Non-Alcoholic Fatty Liver Disease (NAFLD) as Serological Fibrosis Marker
Q37386932Exacerbation of antigen-induced arthritis in urokinase-deficient mice
Q74098969Exposure to chronic hypoxia induces qualitative changes of collagen in the walls of peripheral pulmonary arteries
Q35751580Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion
Q52192855Expression of metalloproteases by cardiac myocytes and fibroblasts in vitro.
Q42469463Expression pattern of the plasminogen activator-plasmin system in human cholesteatoma
Q47970481Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue
Q34143433Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells.
Q77565069Heterogeneous distribution of macrophages, tumour necrosis factor alpha, tissue factor and fibrinolytic regulators in atherosclerotic vessels
Q35869021High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis
Q53243561High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma.
Q27681464Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)
Q38259533Impact of proteolytic enzymes in colorectal cancer development and progression
Q73156216Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats: role of stellate cells
Q42259003Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.
Q72034087Interstitial Collagenase (MMP-1) Expression in Human Carotid Atherosclerosis
Q52051943Is collagen breakdown during periodontitis linked to inflammatory cells and expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gingival tissue?
Q35774094Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion
Q40860401Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases
Q40028510Matrix metalloproteinases in cerebral ischemia
Q34347211Matrix metalloproteinases: from biology to therapeutic strategies in cardiovascular disease
Q36429021Mechanisms of angiogenesis in gliomas
Q41754986Mechanisms of connective tissue matrix destruction in periodontitis
Q79249763Mice lacking tissue plasminogen activator and urokinase plasminogen activator genes show attenuated matrix metalloproteases activity after sciatic nerve crush
Q94452435Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells
Q36499227Oncolytic adenoviruses as antiglioma agents
Q40788383Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells
Q28543252PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures
Q43053623Plasminogen activation in synovial tissues: differences between normal, osteoarthritis, and rheumatoid arthritis joints
Q73401976Plasminogen activator inhibitor-1 as a link between pathological fibrinolysis and arthritis of Behçet's disease
Q71778269Plasminogen activator levels are influenced by location and varicosity in greater saphenous vein
Q71726352Plasminogen modulation of IL-1-stimulated degradation in bovine and human articular cartilage explants. The role of the endogenous inhibitors: PAI-1, alpha 2-antiplasmin, alpha 1-PI, alpha 2-macroglobulin and TIMP
Q33838161Proteases in gastrointestinal neoplastic diseases
Q40788261Protocatechuic Acid from Alpinia oxyphylla Induces Schwann Cell Migration via ERK1/2, JNK and p38 Activation
Q45878050RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.
Q35598320Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover
Q37363376Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator
Q48925891Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier
Q42455239Resveratrol down-regulates a glutamate-induced tissue plasminogen activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons
Q35824305Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases
Q56834793Role of Urokinase in the Fibrogenic Response of the Lung to Mineral Particles
Q73632878Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
Q42800879Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2/9 Mediated through ERK1/2 and p38.
Q38292946Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences
Q33678848Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines
Q57607629Surgical handling of saphenous vein grafts induces expression of matrix metalloproteinase 9
Q33726930Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
Q50466738The effect of suramin on the resorption of bovine nasal cartilage.
Q34249848The generation and characterization of mice expressing a plasmin-inactivating active site mutation
Q41391382Tissue inhibitors of metalloproteinases in liver fibrosis
Q31127095Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice
Q35847359Tissue plasminogen activator reduces the elevated intraocular pressure induced by prednisolone in sheep
Q33887476Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration
Q33350682Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Q30439641Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion
Q52193484Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells.
Q45884595Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Q34346433Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models.
Q36955412uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo
Q44732185uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.

Search more.