Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis

scientific article

Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/V1030460
P932PMC publication ID3185521
P698PubMed publication ID21994556
P5875ResearchGate publication ID51711887

P50authorKarine CrozatQ30503711
Philippe GeorgelQ42717885
P2860cites workStructural bases of unphosphorylated STAT1 association and receptor bindingQ24298555
ATP-sensitive potassium channels mediate survival during infection in mammals and insectsQ24300957
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionQ24633526
Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen miceQ24671578
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculatureQ24795547
Natural killer cells promote early CD8 T cell responses against cytomegalovirusQ27319836
Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the diseaseQ28246426
Herpes simplex virus encephalitis in human UNC-93B deficiencyQ28263759
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomesQ28270473
Munc13-4 regulates granule secretion in human neutrophilsQ28278726
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9Q28292044
Genetic dissection of innate immunity to infection: the mouse cytomegalovirus modelQ28302668
Vital involvement of a natural killer cell activation receptor in resistance to viral infection.Q54010687
Severe herpesvirus infections in an adolescent without natural killer cellsQ55984308
TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell FunctionQ56998126
Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factorQ57083079
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.Q59211381
Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infectionQ59276521
Perforin and Granzymes Have Distinct Roles in Defensive Immunity and ImmunopathologyQ60489482
Functional interactions between dendritic cells and NK cells during viral infectionQ60489540
Studies on the expression of spontaneous and induced interferons in mouse peritoneal macrophages by means of monoclonal antibodies to mouse interferonsQ70187918
An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infectionsQ70890745
Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infectionQ71120565
Latent murine cytomegalovirus infection in macrophagesQ73009731
Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infectionQ73034030
Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infectionQ73112849
Endogenous glucocorticoids protect against cytokine-mediated lethality during viral infectionQ74638482
Infection of dendritic cells by murine cytomegalovirus induces functional paralysisQ74825846
Analysis of in situ NK cell responses during viral infectionQ74844649
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infectionQ78346749
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivoQ81447079
NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populationsQ81479201
Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived miceQ83170090
Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic lociQ28505190
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosisQ28506181
Increased susceptibility to cytomegalovirus infection in beige mutant miceQ28513580
Identification of Lps2 as a key transducer of MyD88-independent TIR signallingQ28587545
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signalingQ28590478
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceQ28594052
A mutation in Rab27a causes the vesicle transport defects observed in ashen miceQ28594384
Stats: transcriptional control and biological impactQ29547776
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral diseaseQ29615967
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndromeQ29620423
Natural killer gene complex (Nkc) allelic variability in inbred mice: evidence for Nkc haplotypes.Q30308222
Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus-infected New Zealand White miceQ30435035
Requisite H2k role in NK cell-mediated resistance in acute murine cytomegalovirus-infected MA/My miceQ30438622
Deficient major histocompatibility complex-linked innate murine cytomegalovirus immunity in MA/My.L-H2b mice and viral downregulation of H-2k class I proteinsQ30441926
A gene-driven ENU-based approach to generating an allelic series in any geneQ30841444
Molecular characterization of ENU mouse mutagenesis and archivesQ33222753
A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH).Q33381950
Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation.Q33489376
Perforin gene defects in familial hemophagocytic lymphohistiocytosis.Q33882431
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycleQ33932725
Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infectionQ33944628
Recognition of a virus-encoded ligand by a natural killer cell activation receptorQ34066048
CytomegalovirusQ34415119
Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cellsQ34467874
Secretory lysosomesQ34522863
Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated miceQ34569831
Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liverQ34795040
Cytomegalovirus vaccines: at last, a major step forwardQ35270894
Calling in the troops: regulation of inflammatory cell trafficking through innate cytokine/chemokine networksQ35570101
Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complexQ35797231
Linking albinism and immunity: the secrets of secretory lysosomesQ35825431
Ikaros is required for plasmacytoid dendritic cell differentiationQ35848777
Does Toll-like receptor 3 play a biological role in virus infections?Q45647163
Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.Q45927264
Inhibition of protein kinases C prevents murine cytomegalovirus replication.Q46610803
Functional analysis of granzyme M and its role in immunity to infectionQ46664113
Analysis of the MCMV resistome by ENU mutagenesisQ46820434
Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).Q48219972
Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamilyQ48367602
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.Q53595834
Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells.Q35874845
Dendritic cells prime natural killer cells by trans-presenting interleukin 15Q36157184
Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleenQ36351047
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administrationQ36365733
Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H.Q36369341
Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infectionQ36370222
Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/betaQ36370726
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).Q36371755
Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infectionQ36377083
Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathwaysQ36381040
Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vesselsQ36401507
Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infectionQ36403423
Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape.Q36619640
Characterization of murine cytomegalovirus m157 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H.Q36828793
Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replicationQ36898711
Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cellsQ37089423
Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral responseQ37234317
Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infectionQ37273319
Ly49h is necessary for genetic resistance to murine cytomegalovirus.Q37315336
Cutting edge: Priming of NK cells by IL-18.Q37499054
Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogoniaQ37550908
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartmentsQ38364212
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensingQ39849800
The T-cell-independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections.Q39868718
Resistance to Murine Cytomegalovirus Linked to the Major Histocompatibility Complex of the MouseQ40107380
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorderQ40536555
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptorsQ40587520
Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liverQ40726486
Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptorsQ40738490
The accelerated phase of Chediak-Higashi syndrome. An expression of the virus-associated hemophagocytic syndrome?Q40816376
Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouseQ40946161
Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cellsQ40981770
Cytoplasmic STAT proteins associate prior to activation.Q41881472
Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivoQ41957577
Distinct requirements for IFNs and STAT1 in NK cell functionQ42494660
Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell functionQ42767949
Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription.Q42805114
Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.Q43626158
Serotonin Deficiency and Prolonged Bleeding in Beige MiceQ44330793
Specific and nonspecific NK cell activation during virus infectionQ44496692
Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirusQ44585486
Molecular and biological characterization of new strains of murine cytomegalovirus isolated from wild mice.Q44794388
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P304page(s)460-483
P577publication date2009-10-20
P1433published inVirusesQ7935305
P1476titleIdentification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis
P478volume1

Reverse relations

Q37987129The role of humoral innate immunity in hepatitis C virus infection.cites workP2860