CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections

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CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00545-11
P932PMC publication ID3186990
P698PubMed publication ID21788472
P5875ResearchGate publication ID51520530

P2093author name stringEarl R Kern
Caroll B Hartline
Mark N Prichard
Debra C Quenelle
E Randall Lanier
P2860cites workAlkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.Q37401749
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Early intervention with high-dose acyclovir treatment during primary herpes simplex virus infection reduces latency and subsequent reactivation in the nervous system in vivo.Q43749186
Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, double-blind, placebo-controlled clinical trialQ43886317
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Vidarabine versus acyclovir therapy in herpes simplex encephalitisQ48385636
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Safety and Efficacy of High-Dose Intravenous Acyclovir in the Management of Neonatal Herpes Simplex Virus InfectionsQ22305966
The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the gangliaQ24523533
Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution StudiesQ24629979
Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latencyQ28273745
Persistence of herpes simplex virus DNA in cerebrospinal fluid of neonates with herpes simplex virus encephalitis.Q33405731
Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal functionQ33676105
The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivationQ33784836
Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitroQ33935329
Current recommendations for the treatment of genital herpes.Q34127423
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Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infectionsQ34510424
Herpes simplex virus resistance to antiviral drugsQ34531396
Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapyQ34579981
Recurrent antiviral-resistant genital herpes in an immunocompetent patientQ34698957
Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanismsQ34756486
Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years' experience with acyclovirQ34918273
Progress in meeting today's demands in genital herpes: an overview of current managementQ34918299
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.Q35547866
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxvirusesQ36295446
Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management.Q36478736
Management of HSV encephalitis in adults and neonates: diagnosis, prognosis and treatment.Q36937380
Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs.Q37283124
Novel approaches in fighting herpes simplex virus infectionsQ37316071
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P433issue10
P407language of work or nameEnglishQ1860
P921main subjectaciclovirQ147101
P304page(s)4728-4734
P577publication date2011-07-25
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleCMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections
P478volume55