Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides

scientific article

Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JB.05510-11
P932PMC publication ID3187194
P698PubMed publication ID21856856

P2093author name stringAbraham L Sonenshein
Shaun R Brinsmade
P2860cites workHomeoviscous adaptation--a homeostatic process that regulates the viscosity of membrane lipids in Escherichia coliQ24622178
PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiaeQ28295796
Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levelsQ28364118
Role and regulation of Bacillus subtilis glutamate dehydrogenase genesQ28488889
A lipA (yutB) mutant, encoding lipoic acid synthase, provides insight into the interplay between branched-chain and unsaturated fatty acid biosynthesis in Bacillus subtilisQ28488929
Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulenceQ29346597
Integration of metabolism and virulence by Clostridium difficile CodYQ29346637
Repression of Clostridium difficile toxin gene expression by CodY.Q29346638
Genetic and biochemical analysis of CodY-binding sites in Bacillus subtilisQ29346684
Elaborate transcription regulation of the Bacillus subtilis ilv-leu operon involved in the biosynthesis of branched-chain amino acids through global regulators of CcpA, CodY and TnrA.Q29346687
Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched-chain amino acidsQ29346704
Role of the Fur regulon in iron transport in Bacillus subtilisQ29346707
Identification of genes and gene products whose expression is activated during nitrogen-limited growth in Bacillus subtilisQ33243930
Regulation of histidine and proline degradation enzymes by amino acid availability in Bacillus subtilis.Q33780241
Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus.Q33825978
Direct targets of CodY in Staphylococcus aureus.Q33876899
Role of bkdR, a transcriptional activator of the sigL-dependent isoleucine and valine degradation pathway in Bacillus subtilisQ33991603
Transduction of linked genetic characters of the host by bacteriophage P1.Q34237612
RelA protein is involved in induction of genetic competence in certain Bacillus subtilis strains by moderating the level of intracellular GTP.Q34314755
Regulation of CodY activity through modulation of intracellular branched-chain amino acid poolsQ34433377
Structural rearrangement accompanying ligand binding in the GAF domain of CodY from Bacillus subtilis.Q35084439
Essential bacterial functions encoded by gene pairs.Q35634749
Recent developments in bacterial cold-shock responseQ35761291
A target for carbon source-dependent negative regulation of the citB promoter of Bacillus subtilisQ36158064
Evidence that Bacillus subtilis sporulation induced by the stringent response is caused by the decrease in GTP or GDP.Q36388894
Interaction of Bacillus subtilis CodY with GTP.Q36421918
CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonizationQ36422216
Global regulation by (p)ppGpp and CodY in Streptococcus mutansQ36804362
CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expressionQ37191471
The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulenceQ37355928
The Lactococcus lactis CodY regulon: identification of a conserved cis-regulatory element.Q38323295
Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysisQ38357042
Heavy involvement of stringent transcription control depending on the adenine or guanine species of the transcription initiation site in glucose and pyruvate metabolism in Bacillus subtilis.Q39415536
Transcriptional control of the low-temperature-inducible des gene, encoding the delta5 desaturase of Bacillus subtilis.Q39497989
The decrease of guanine nucleotides initiates sporulation of Bacillus subtilisQ39687514
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.Q39743843
CodY Is a Nutritional Repressor of Flagellar Gene Expression in Bacillus subtilisQ39749070
An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transportQ39846986
Transcriptional organization and posttranscriptional regulation of the Bacillus subtilis branched-chain amino acid biosynthesis genesQ40867560
Molecular mechanisms underlying the positive stringent response of the Bacillus subtilis ilv-leu operon, involved in the biosynthesis of branched-chain amino acidsQ41763525
A region of Bacillus subtilis CodY protein required for interaction with DNA.Q41781460
Contributions of multiple binding sites and effector-independent binding to CodY-mediated regulation in Bacillus subtilisQ41814819
Gene-protein relationships in the flagellar hook-basal body complex of Bacillus subtilis: sequences of the flgB, flgC, flgG, fliE and fliF genesQ42623920
Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilisQ44174334
Intracellular effectors regulating the activity of the Lactococcus lactis CodY pleiotropic transcription regulator.Q44959794
Overall control of nitrogen metabolism in Lactococcus lactis by CodY, and possible models for CodY regulation in Firmicutes.Q46844372
The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteriaQ46952678
Linking the nutritional status of Streptococcus pyogenes to alteration of transcriptional gene expression: the action of CodY and RelA.Q46986388
Characterization of the codY gene and its influence on biofilm formation in Bacillus cereusQ48075376
Complete analysis of cellular nucleotides by two-dimensional thin layer chromatographyQ50213368
Fatty Acid-requiring Mutant of Bacillus subtilis Defective in Branched Chain α-Keto Acid DehydrogenaseQ53724593
Genetics and physiology of the rel system of Bacillus subtilisQ54563383
Effect of unusual guanosine nucleotides on the activities of some escherichia coli cellular enzymesQ72502843
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)5637-5648
P577publication date2011-08-19
P1433published inJournal of BacteriologyQ478419
P1476titleDissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides
P478volume193

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cites work (P2860)
Q36172807Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors
Q42020451CodY Regulates SigD Levels and Activity by Binding to Three Sites in the fla/che Operon
Q35214779CodY regulates expression of the Bacillus subtilis extracellular proteases Vpr and Mpr.
Q38981751CodY, a master integrator of metabolism and virulence in Gram-positive bacteria
Q34604406Comparative transcription analysis and toxin production of two fluoroquinolone-resistant mutants of Clostridium perfringens
Q37073234De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In Vivo
Q26996687Diversity in (p)ppGpp metabolism and effectors
Q41764949GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes
Q34660264Genome-wide identification of Bacillus subtilis CodY-binding sites at single-nucleotide resolution
Q53689781Guanine limitation results in CodY-dependent and -independent alteration of Staphylococcus aureus physiology and gene expression.
Q33730757Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.
Q61806523Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027
Q35997875Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.
Q35810175Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.
Q33362239Interplay of CodY and ScoC in the Regulation of Major Extracellular Protease Genes of Bacillus subtilis
Q60301784Laboratory strains of Bacillus anthracis exhibit pervasive alteration in expression of proteins related to sporulation under laboratory conditions relative to genetically related wild strains
Q39260241Lowering GTP level increases survival of amino acid starvation but slows growth rate for Bacillus subtilis cells lacking (p)ppGpp.
Q50875466Modeling leucine's metabolic pathway and knockout prediction improving the production of surfactin, a biosurfactant from Bacillus subtilis.
Q26799806Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria
Q35214784Role of branched-chain amino acid transport in Bacillus subtilis CodY activity
Q33899541Streptococcus pyogenes polymyxin B-resistant mutants display enhanced ExPortal integrity
Q34499356The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression.
Q27728004The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism

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