Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing

scholarly article

Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing is …
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scholarly articleQ13442814

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P819ADS bibcode2001PNAS...98.4587S
P356DOI10.1073/PNAS.071063898
P8608Fatcat IDrelease_ek5b4igcmrh5bhnir5nq2v6dgm
P932PMC publication ID31878
P698PubMed publication ID11287644
P5875ResearchGate publication ID12045595

P50authorPeter C. DohertyQ309814
Julia L. HurwitzQ97727006
P2093author name stringS W White
B Jones
J M Riberdy
K S Slobod
S Surman
T D Lockey
P2860cites workThe HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and ImmunogensQ22242262
Viral immune evasion due to persistence of activated T cells without effector functionQ24646943
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Raster3D: photorealistic molecular graphicsQ27860557
Complete nucleotide sequence of the AIDS virus, HTLV-IIIQ28259080
The antigenic structure of the HIV gp120 envelope glycoproteinQ28274698
Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral responseQ28282853
Get into the groove! Targeting antigens to MHC class II.Q33815384
The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentationQ33815394
Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sortingQ33815419
Mechanisms and consequences of peptide selection by the I-Ak class II moleculeQ33815430
Peptide exchange in MHC moleculesQ33815435
Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glandsQ33930607
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.Q34485526
CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infectionQ35873254
Roles of alpha beta and gamma delta T cell subsets in viral immunityQ35876930
CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gammaQ36338436
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognitionQ36344766
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotypeQ36349414
Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodiesQ36620408
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infectionQ36637922
Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodiesQ36884458
Polyadenylylation of sea urchin histone RNA sequences in transfected COS cellsQ37678089
HIV type 1 envelope sequence diversity in inner city communityQ39392294
Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boostingQ39397356
MHC ligands and peptide motifs: first listingQ40612811
A novel vaccine regimen utilizing DNA, vaccinia virus and protein immunizations for HIV-1 envelope presentationQ40818252
Establishment and characterization of human immunodeficiency virus type 1 (HIV-1) envelope-specific CD4+ T lymphocyte lines from HIV-1-seropositive patientsQ41338390
MHC-specific recognition of a bacterial superantigen by weakly reactive T cells.Q41467916
The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responsesQ41870329
Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs.Q42611420
T cell recognition of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region.Q42991684
High prevalence of hypervariable region 1-specific and -cross-reactive CD4(+) T cells in HCV-infected individuals responsive to IFN-alpha treatmentQ42998082
A synthetic peptide from the first conserved region in the envelope protein gp160 is a strong T-cell epitope in HIV-infected chimpanzees and humansQ43420730
Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirusQ43817319
LacZ inducible, antigen/MHC-specific T cell hybridsQ44031720
The immune response of BALB/c mice to influenza hemagglutinin: commonality of the B cell and T cell repertoires and their relevance to antigenic driftQ45147766
Eliciting HIV-1 envelope-specific antibodies with mixed vaccinia virus recombinantsQ45763280
Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene.Q45787219
Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout miceQ45788824
T cell multideterminant regions in the human immunodeficiency virus envelope: toward overcoming the problem of major histocompatibility complex restrictionQ45846878
CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 miceQ45860713
Help for cytotoxic-T-cell responses is mediated by CD40 signallingQ47982749
Effect of natural HIV-1 envelope V1-V2 sequence diversity on the binding of V3-specific and non-V3-specific antibodiesQ48042932
Does the key to a successful HIV type 1 vaccine lie among the envelope sequences of infected individuals?Q48070843
Two better cell lines for making hybridomas expressing specific T cell receptors.Q48287125
Comprehensive T-cell epitope mapping of HIV-1 env antigens reveals many areas recognized by HIV-1-seropositive and by low-risk HIV-1-seronegative individuals.Q52372500
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesQ55042699
Definition of an immunodominant T cell epitope contained in the envelope gp41 sequence of HIV-1Q55241675
HIV-1 peptides induce a proliferative response in lymphocytes from infected persons.Q55242365
HIV type 1 variation in World Health Organization-sponsored vaccine evaluation sites: genetic screening, sequence analysis, and preliminary biological characterization of selected viral strains. WHO Network for HIV Isolation and CharacterizationQ56921434
HIV Type 1 Variation in World Health Organization-Sponsored Vaccine Evaluation Sites: Genetic Screening, Sequence Analysis, and Preliminary Biological Characterization of Selected Viral StrainsQ58415406
Antigenic peptides recognized by T lymphocytes from AIDS viral envelope-immune humansQ59046097
Identification of T-cell epitopes without B-cell activity in the first and second conserved regions of the HIV Env proteinQ67699031
Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cellsQ68083664
Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cellsQ69909322
Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptidesQ77320371
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)4587-4592
P577publication date2001-04-03
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleLocalization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing
P478volume98

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cites work (P2860)
Q28389250A Multi-Vector, Multi-Envelope HIV-1 Vaccine
Q34492984A closer look at proteolysis and MHC-class-II-restricted antigen presentation.
Q43712997A five-residue HIV envelope helper T cell determinant: does this peptide-MHC interaction leave the binding groove half empty?
Q77492279A highly sensitive single-cell assay detects T-helper cell responses missed by conventional interleukin-2-based methods
Q36315473A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein
Q27481378A systematic bioinformatics approach for selection of epitope-based vaccine targets
Q45735715Allocation of helper T-cell epitope immunodominance according to three-dimensional structure in the human immunodeficiency virus type I envelope glycoprotein gp120.
Q34057942Analysis of HLA A*02 association with vaccine efficacy in the RV144 HIV-1 vaccine trial
Q37373708Antigen structure influences helper T-cell epitope dominance in the human immune response to HIV envelope glycoprotein gp120.
Q36687906Bioinformatics for study of autoimmunity
Q84957632CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection
Q30384608CD4+ T-cell epitope prediction using antigen processing constraints
Q34100215Clearance of HIV type 1 envelope recombinant sendai virus depends on CD4+ T cells and interferon-gamma but not B cells, CD8+ T cells, or perforin
Q79125450Clustering of Th Cell Epitopes on Exposed Regions of HIV Envelope Despite Defects in Antibody Activity
Q33582318Comparative quantitative mass spectrometry analysis of MHC class II-associated peptides reveals a role of GILT in formation of self-peptide repertoire
Q36371928Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: processing of tumor antigen MUC1 glycopeptides for presentation to major histocompatibility complex class II-restricted T cells
Q34059460Comprehensive analysis of contributions from protein conformational stability and major histocompatibility complex class II-peptide binding affinity to CD4+ epitope immunogenicity in HIV-1 envelope glycoprotein
Q37422520Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
Q41360867Computational analysis of cysteine proteases (Clan CA, Family Cl) of Leishmania major to find potential epitopic regions
Q41078346Conformational instability governed by disulfide bonds partitions the dominant from subdominant helper T-cell responses specific for HIV-1 envelope glycoprotein gp120.
Q24288762Conservation and variability of dengue virus proteins: implications for vaccine design
Q34717906Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen
Q36473515Enhancement of gp120-Specific Immune Responses by Genetic Vaccination with the Human Immunodeficiency Virus Type 1 Envelope Gene Fused to the Gene Coding for Soluble CTLA4
Q33883887Evaluating the immunogenicity of a disulfide-stabilized, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1
Q80966875Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins
Q95323134Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
Q28394899Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials
Q33322206Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes
Q29307502Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
Q35122914Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing
Q34128586Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
Q45421005Immunogenicity of calreticulin-bound murine leukemia virus glycoprotein gp90.
Q33725711Influence of disulfide-stabilized structure on the specificity of helper T-cell and antibody responses to HIV envelope glycoprotein gp120
Q34781685Limited breadth of a T-helper cell response to a human immunodeficiency virus envelope protein
Q55877037Long lived multi-isotype anti-HIV antibody responses following a prime-double boost immunization strategy
Q42729706MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles
Q47549431Mapping HLA-A2, -A3 and -B7 supertype-restricted T-cell epitopes in the ebolavirus proteome
Q47993951Minor components of a multi-envelope HIV vaccine are recognized by type-specific T-helper cells
Q87163708Modulation of HIVGP120 Antigen-Specific Immune Responses In Vivo by Δ9-Tetrahydrocannabinol
Q44189653Multi-envelope HIV-1 vaccine devoid of SIV components controls disease in macaques challenged with heterologous pathogenic SHIV.
Q36475897Murine Monoclonal Antibodies for Antigenic Discrimination of HIV-1 Envelope Proteins
Q92093979Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin
Q28611993Presentation of antigens by MHC class II molecules: getting the most out of them
Q24645308Proximal glycans outside of the epitopes regulate the presentation of HIV-1 envelope gp120 helper epitopes
Q56893551Respiratory syncytial virus vaccine development
Q40334895SARS coronavirus nucleocapsid immunodominant T-cell epitope cluster is common to both exogenous recombinant and endogenous DNA-encoded immunogens
Q40459706Short Communication: Parallel Analyses of Systemic and Local Vaccinations with Envelope Formulated in Adjuvant for Induction of HIV-Specific Antibodies in the Vaginal Mucosa.
Q34477154Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid
Q33900413Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction
Q55084358Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection.
Q42648564T cell epitope "hotspots" on the HIV Type 1 gp120 envelope protein overlap with tryptic fragments displayed by mass spectrometry
Q28383908Target peptide sequence within infectious human immunodeficiency virus type 1 does not ensure envelope-specific T-helper cell reactivation: influences of cysteine protease and gamma interferon-induced thiol reductase activities
Q39422790The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine
Q36424504The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers
Q42947548Toward the rational design of a malaria vaccine construct using the MSP3 family as an example: contribution of immunogenicity studies in models
Q30414377UV-inactivated vaccinia virus (VV) in a multi-envelope DNA-VV-protein (DVP) HIV-1 vaccine protects macaques from lethal challenge with heterologous SHIV.
Q40935197Vitamin A deficient mice exhibit increased viral antigens and enhanced cytokine/chemokine production in nasal tissues following respiratory virus infection despite the presence of FoxP3+ T cells
Q35166856WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies
Q33916280Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response

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