Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models.

scientific article

Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1068965346
P356DOI10.2119/MOLMED.2010.00264
P932PMC publication ID3188862
P698PubMed publication ID21666956
P5875ResearchGate publication ID51213243

P50authorPeter LundbäckQ37374997
Ulf AnderssonQ37375023
Karin PalmbladQ58739051
P2093author name stringHanna Schierbeck
Helena Erlandsson-Harris
Lars Ottosson
Lena Klevenvall
P2860cites workA critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine releaseQ24321082
The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathwayQ24538824
Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end productsQ28116270
Release of chromatin protein HMGB1 by necrotic cells triggers inflammationQ28131815
Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activationQ28262320
The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous systemQ28567291
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytesQ28574795
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNAQ28587147
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretionQ33193752
Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis.Q35869016
HMGB1 is a therapeutic target for sterile inflammation and infectionQ35953553
Role of HMGB1 in apoptosis-mediated sepsis lethalityQ36228722
High-mobility group box proteins modulate tumor necrosis factor-alpha expression in osteoclastogenesis via a novel deoxyribonucleic acid sequenceQ36629269
Utility of animal models for identification of potential therapeutics for rheumatoid arthritisQ37022699
Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritisQ38274480
HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assayQ40230862
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.Q40249835
The extracellular release of HMGB1 during apoptotic cell deathQ40253423
High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function.Q41080193
HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE.Q41933401
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritisQ46401884
Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vesselsQ46829587
High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritisQ47850293
Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in ratsQ48106802
HMGB1 is a bone-active cytokine.Q53530203
TLR4 mediates early graft failure after intraportal islet transplantation.Q54419154
High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitisQ58876474
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophagesQ59062762
Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastasesQ59084980
Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activityQ60692920
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis modelQ60746248
Activation of gene expression in human neutrophils by high mobility group box 1 proteinQ73087842
High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokineQ73249056
P433issue9-10
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)1039-1044
P577publication date2011-06-07
P1433published inMolecular MedicineQ6895961
P1476titleMonoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models
P478volume17