Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.

scientific article

Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2015.02.007
P932PMC publication ID4387075
P698PubMed publication ID25700650
P5875ResearchGate publication ID272624855

P50authorAndrew C EmeryQ57007602
Hannah A HathawayQ57008862
P2093author name stringJarda T Wroblewski
Tara Gelb
Ewa Grajkowska
Sergey Pshenichkin
Barry B Wolfe
P2860cites workDisruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.Q45729180
Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.Q46471412
Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brainQ48066974
Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brainQ48224778
The metabotropic glutamate receptor 1, GRM1: evaluation as a candidate gene for inherited forms of cerebellar ataxia.Q50271229
The role of depolarization in the survival and differentiation of cerebellar granule cells in culture.Q51789112
Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture.Q52211395
What is pharmacological 'affinity'? Relevance to biased agonism and antagonism.Q53149817
N-methyl-D-aspartate promotes the survival of cerebellar granule cells in cultureQ69929483
3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampusQ72069910
Temporal and depolarization-induced changes in the absolute amounts of mRNAs encoding metabotropic glutamate receptors in cerebellar granule neurons in vitroQ72728960
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Sequence and expression of a metabotropic glutamate receptorQ28280066
Metabotropic glutamate receptor 1 and glutamate signaling in human melanomaQ28290954
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate bindingQ28370513
Molecular diversity of glutamate receptors and implications for brain functionQ28611078
Beta-arrestins and cell signalingQ29616793
Pharmacology and functions of metabotropic glutamate receptorsQ29619150
Metabotropic glutamate receptors: from the workbench to the bedsideQ30448778
Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progressionQ33560677
Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Q33619504
Beyond desensitization: physiological relevance of arrestin-dependent signaling.Q33890802
Teaching old receptors new tricks: biasing seven-transmembrane receptorsQ33985759
The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.Q34074283
JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonistQ34369735
Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitroQ35184527
Quantifying ligand bias at seven-transmembrane receptors.Q35188090
A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptorQ35817527
Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.Q36105482
Functional effects of GRM1 suppression in human melanoma cellsQ36409682
Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.Q36439309
Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptorsQ36773326
Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptorQ37021962
The origins of diversity and specificity in g protein-coupled receptor signalingQ37131419
Metabotropic glutamate 1 receptor: current concepts and perspectives.Q37359380
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?Q37981470
Biased ligands at G-protein-coupled receptors: promise and progressQ38216119
Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons.Q38383460
Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomasQ38971337
Cell type-specific differences in the coupling of recombinant mGlu1alpha receptors to endogenous G protein sub-populationsQ40811646
Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells.Q41931681
Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.Q42264500
Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cellsQ43783951
L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.Q44370393
P1104number of pages10
P304page(s)199-208
P577publication date2015-02-17
P1433published inNeuropharmacologyQ15332439
P1476titlePharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism
P478volume93

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cites work (P2860)
Q47865915Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery
Q46083239Control of neuronal excitability by Group I metabotropic glutamate receptors
Q91581400Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Q59335641Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Q38567309Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias
Q37464855Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling
Q33562835β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.

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