| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Trevor M Penning | Q40206892 |
| P2860 | cites work | Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer | Q24293323 |
| Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids | Q24294264 | ||
| The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases | Q24300164 | ||
| Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme | Q24305053 | ||
| NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels | Q24307565 | ||
| Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones | Q24532164 | ||
| Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation | Q24618043 | ||
| The crystal structure of the aldose reductase.NADPH binary complex | Q27642179 | ||
| Crystal structure of human prostaglandin F synthase (AKR1C3) | Q27643176 | ||
| Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10 | Q27649354 | ||
| Crystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis | Q27650311 | ||
| Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1) | Q27652485 | ||
| Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme | Q27731211 | ||
| Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily | Q27731273 | ||
| Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+ | Q27733250 | ||
| cDNA cloning, expression and characterization of human prostaglandin F synthase | Q28141935 | ||
| Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review | Q28258269 | ||
| An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications | Q28275993 | ||
| Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme | Q28290487 | ||
| Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2 | Q28307550 | ||
| Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia | Q28472176 | ||
| Succinic Semialdehyde Dehydrogenase: Biochemical–Molecular–Clinical Disease Mechanisms, Redox Regulation, and Functional Significance | Q28743137 | ||
| Efficacy and Safety of Aldose Reductase Inhibitor for the Treatment of Diabetic Cardiovascular Autonomic Neuropathy: Systematic Review and Meta-Analysis | Q28972373 | ||
| Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm | Q29547194 | ||
| Comparative anatomy of the aldo-keto reductase superfamily | Q30043211 | ||
| Structure of porcine aldehyde reductase holoenzyme. | Q30193232 | ||
| Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor | Q31461224 | ||
| The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene | Q31520246 | ||
| Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia | Q33567452 | ||
| Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency | Q34042571 | ||
| Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. | Q34206454 | ||
| N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor | Q34259807 | ||
| Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase. | Q34267730 | ||
| Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice | Q34768479 | ||
| Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate | Q35102971 | ||
| Genetic analysis of aldose reductase in diabetic complications | Q35181336 | ||
| Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. | Q35596001 | ||
| Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride. | Q35869909 | ||
| The backdoor pathway to dihydrotestosterone | Q35935852 | ||
| Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating | Q36009855 | ||
| Aldo-keto reductases and bioactivation/detoxication. | Q36592650 | ||
| Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology | Q36607363 | ||
| Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature. | Q37134764 | ||
| Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10) | Q37151656 | ||
| Hyperglycemia, Polyol Metabolism, and Complications of Diabetes Mellitus | Q38120921 | ||
| Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells | Q38327752 | ||
| Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases | Q38338922 | ||
| In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). | Q38979373 | ||
| Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth | Q39101528 | ||
| Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3 | Q39991413 | ||
| Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells | Q40735548 | ||
| The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function | Q42151282 | ||
| The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). | Q43577683 | ||
| Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study | Q43748985 | ||
| The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. | Q44288670 | ||
| The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. | Q44326923 | ||
| The aldo-keto reductase superfamily homepage | Q44326998 | ||
| SRD5B1 (AKR1D1) gene analysis in delta(4)-3-oxosteroid 5beta-reductase deficiency: evidence for primary genetic defect | Q44805409 | ||
| Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors. | Q45593153 | ||
| Long-term treatment with ranirestat (AS-3201), a potent aldose reductase inhibitor, suppresses diabetic neuropathy and cataract formation in rats | Q46494556 | ||
| Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease | Q46716649 | ||
| AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer | Q46842961 | ||
| Human Aldose Reductase: pK of Tyrosine 48 Reveals the Preferred Ionization State for Catalysis and Inhibition | Q46938828 | ||
| Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase | Q47870304 | ||
| A new nomenclature for the aldo-keto reductase superfamily | Q48772502 | ||
| Allopregnanolone in women with premenstrual syndrome. | Q51516389 | ||
| Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. | Q53359945 | ||
| Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding | Q57752908 | ||
| Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on progression of diabetic neuropathy and other microvascular complications: multivariate epidemiological analysis based on patient background factors and severity of diabetic n | Q59925982 | ||
| Reversal of stage-I sugar cataract by Sorbinil, an aldose reductase inhibitor | Q69956779 | ||
| Aldose reductase inhibition improves nerve conduction velocity in diabetic patients | Q70424271 | ||
| Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase | Q70882010 | ||
| Delta 4-3-oxosteroid 5 beta-reductase deficiency causing neonatal liver failure and hemochromatosis | Q72757062 | ||
| Gene analysis in delta 4-3-oxosteroid 5 beta-reductase deficiency | Q73048075 | ||
| Abnormally low ratio of cholic acid to chenodeoxycholic acid due to a deficiency of 3-oxo-delta4-steroid 5beta-reductase | Q73143659 | ||
| Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione | Q74523810 | ||
| Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine | Q74845119 | ||
| Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners | Q77394870 | ||
| The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase | Q77937499 | ||
| Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9) | Q81234512 | ||
| An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone | Q81469973 | ||
| Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid | Q84076453 | ||
| Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol | Q93941474 | ||
| P304 | page(s) | 236-246 | |
| P577 | publication date | 2014-10-07 | |
| P1433 | published in | Chemico-biological Interactions | Q14923137 |
| P1476 | title | The aldo-keto reductases (AKRs): Overview | |
| P478 | volume | 234 |
| Q36407279 | A Novel Aldo-Keto Reductase, HdRed, from the Pacific Abalone Haliotis discus hannai, Which Reduces Alginate-derived 4-Deoxy-L-erythro-5-hexoseulose Uronic Acid to 2-Keto-3-deoxy-D-gluconate |
| Q53703893 | AKR1C enzymes sustain therapy resistance in paediatric T-ALL. |
| Q89599121 | Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats |
| Q28078668 | Aldo-Keto Reductases 1B in Adrenal Cortex Physiology |
| Q90261203 | Aldo-keto Reductase Metabolizes Glyphosate and Confers Glyphosate Resistance in Echinochloa colona |
| Q37306965 | Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells |
| Q46310403 | Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi |
| Q91525186 | Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis |
| Q92007574 | Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview |
| Q58091238 | Altered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease |
| Q40079132 | An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain |
| Q92923912 | Analysis of Aldo-Keto Reductase Gene Family and Their Responses to Salt, Drought, and Abscisic Acid Stresses in Medicago truncatula |
| Q61810575 | Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma |
| Q42700266 | Babesia microti Aldo-keto Reductase-Like Protein Involved in Antioxidant and Anti-parasite Response |
| Q104111285 | Comparative proteomic analysis of the sweetpotato provides insights into response mechanisms to Fusarium oxysporum f. sp. batatas |
| Q92123827 | Crystal Structure and Biophysical Analysis of Furfural-Detoxifying Aldehyde Reductase from Clostridium beijerinckii |
| Q35841505 | Crystallographic analysis of a novel aldo-keto reductase from Thermotoga maritima in complex with NADP⁺. |
| Q47134231 | Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae |
| Q64916993 | Diagnostic and Prognostic Potential of AKR1B10 in Human Hepatocellular Carcinoma. |
| Q64092883 | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation |
| Q93081123 | Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action |
| Q48116483 | Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma |
| Q38824412 | Extreme makeover: Engineering the activity of a thermostable alcohol dehydrogenase (AdhD) from Pyrococcus furiosus |
| Q88979062 | Formalin-Fixed Paraffin-Embedded Tissues-An Untapped Biospecimen for Biomonitoring DNA Adducts by Mass Spectrometry |
| Q64072846 | Functional identification of alginate lyase from the brown alga Saccharina japonica |
| Q48555282 | Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progestogens 17α,20β-di- and 17α,20β,21α-trihydroxy-4-pregnen-3-one |
| Q47118384 | Genome-Wide Identification of Chalcone Reductase Gene Family in Soybean: Insight into Root-Specific GmCHRs and Phytophthora sojae Resistance |
| Q57184467 | Geotrichum candidum gene expression and metabolite accumulation inside the cells reflect the strain oxidative stress sensitivity and ability to produce flavour compounds |
| Q40169578 | HPA Axis Genes, and Their Interaction with Childhood Maltreatment, are Related to Cortisol Levels and Stress-Related Phenotypes |
| Q91650415 | High Throughput Screening Platform for a FAD-Dependent L-Sorbose Dehydrogenase |
| Q37633872 | High expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma |
| Q51745066 | Identification and characterization of bacterial enzymes catalyzing the synthesis of 1,8-dihydroxynaphthalene, a key precursor of dihydroxynaphthalene melanin, from Sorangium cellulosum. |
| Q51140683 | Identification and functional characterization of four novel aldo/keto reductases in Anabaena sp. PCC 7120 by integrating wet lab with in silico approaches. |
| Q111348135 | Identification of Aldose Reductase 1 as a pine wood nematode secretory enzyme and generation and characterization of its monoclonal antibodies |
| Q42165853 | Identification of a Noroxomaritidine Reductase with Amaryllidaceae Alkaloid Biosynthesis Related Activities. |
| Q41630307 | Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases |
| Q52714849 | In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals. |
| Q93087659 | Increased salivary AKR1B10 level: Association with progression and poor prognosis of oral squamous cell carcinoma |
| Q89983086 | Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals |
| Q50058164 | Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
| Q64891091 | Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation. |
| Q91919298 | Metabolomics Profiling and AKR Characterization During Paurometabolous Development of Corythucha ciliata (Hemiptera: Tingidae) |
| Q62553186 | New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study |
| Q40355492 | Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies |
| Q90251275 | OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL |
| Q35554080 | Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls |
| Q41710616 | Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases |
| Q41848693 | Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. |
| Q91880089 | Positive Selection Evidence in Xylose-Related Genes Suggests Methylglyoxal Reductase as a Target for the Improvement of Yeasts' Fermentation in Industry |
| Q57492406 | Potential of AKR1B10 as a Biomarker and Therapeutic Target in Type 2 Leprosy Reaction |
| Q38880368 | Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015. |
| Q92996408 | Protein identification from the parotoid macrogland secretion of Duttaphrynus melanostictus |
| Q60913070 | RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia |
| Q33822491 | Semi-rational engineering of a thermostable aldo-keto reductase from Thermotoga maritima for synthesis of enantiopure ethyl-2-hydroxy-4-phenylbutyrate (EHPB) |
| Q40089027 | Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses. |
| Q40765775 | Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy |
| Q59806319 | Structural insight into -xylose utilization by xylose reductase from Scheffersomyces stipitis |
| Q104472064 | Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating |
| Q37209580 | TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation |
| Q37554961 | The Coptotermes gestroi aldo-keto reductase: a multipurpose enzyme for biorefinery applications |
| Q50230052 | The gymnastics of epigenomics in rice |
| Q91106231 | Unraveling oxidative stress response in the cestode parasite Echinococcus granulosus |
| Q91783124 | Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma |
| Q53081552 | VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions. |
| Q58572616 | Wentilactone A induces cell apoptosis by targeting AKR1C1 gene via the IGF-1R/IRS1/PI3K/AKT/Nrf2/FLIP/Caspase-3 signaling pathway in small cell lung cancer |
Search more.