Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

scientific article

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.202853
P932PMC publication ID3190680
P698PubMed publication ID21665953

P50authorGiulio G. MuccioliQ38601106
Silvia Ortega-GutiérrezQ44090471
María L López-RodríguezQ57037346
José A CisnerosQ80742949
P2093author name stringCong Xu
Nephi Stella
Eric A Horne
William R Marrs
Yi Hsing Lin
P2860cites workCrystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signalingQ24324741
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolaseQ24555807
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effectsQ24569799
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptorsQ24617322
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerolQ24649418
A second endogenous cannabinoid that modulates long-term potentiationQ28248073
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid systemQ28590486
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Modulation of anxiety through blockade of anandamide hydrolysisQ29615902
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.Q30492114
The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomasQ33525520
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysisQ34234907
Cannabinoid tolerance and dependence.Q36441232
An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brainQ36591816
A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitorsQ37332639
Measuring endocannabinoid hydrolysis: refining our tools and understandingQ37474536
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolaseQ40086523
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cellsQ40158906
Receptor-dependent formation of endogenous cannabinoids in cortical neuronsQ43570212
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.Q44963304
2-AG + 2 new players = forecast for therapeutic advancesQ46838615
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2Q72240764
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
niacinamideQ192423
endocannabinoidsQ10483908
P1104number of pages6
P304page(s)28723-28728
P577publication date2011-06-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleDual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons
P478volume286