Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids

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Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.271460
P932PMC publication ID3191022
P698PubMed publication ID21730055

P2093author name stringRichard Charboneau
Roderick A Barke
Sabita Roy
Subhas Das
Jennifer Kelschenbach
P2860cites workERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.Q50335945
Pro-inflammatory cytokines induce the transcription factors C/EBPbeta and C/EBPdelta in astrocytesQ61774073
Stress- and morphine-induced elevations of plasma and tissue cholesterol in mice: reversal by naltrexoneQ67947042
Quantitative properties of plasma corticosterone elevation induced by naloxone-precipitated withdrawal in morphine-dependent ratsQ72576794
Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approachQ73694416
Cross talk between nitric oxide and ERK1/2 signaling pathway in the spinal cord mediates naloxone-precipitated withdrawal in morphine-dependent ratsQ83377972
Regulation of interleukin 12 p40 expression through an NF-kappa B half-siteQ24651221
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cellsQ24678409
Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokinesQ30919473
Cytokine patterns in the pathogenesis of human leishmaniasisQ33895266
Interleukin 12 at the site of disease in tuberculosisQ34140928
Increased sensitivity to Salmonella enterica serovar Typhimurium infection in mice undergoing withdrawal from morphine is associated with suppression of interleukin-12.Q34194770
Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alphaQ34245882
Non-genomic effects of glucocorticoids in the neural system. Evidence, mechanisms and implicationsQ34349834
Stress-induced immunomodulation and the implications for healthQ34506497
Stress and relapse to drug seeking: studies in laboratory animals shed light on mechanisms and sources of long-term vulnerabilityQ35080432
Making a bad thing worse: adverse effects of stress on drug addictionQ36407029
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteinsQ36570254
Modulation of immune function by morphine: implications for susceptibility to infectionQ37015395
Effects of opioid tolerance and withdrawal on the immune systemQ37015416
The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings.Q37022008
Opioid-induced immunosuppressionQ37237103
Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawalQ37244714
Activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent ratsQ38318756
Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factorsQ38346654
Disparate regulation of LPS-induced MAPK signaling and IL-12p40 expression between different myeloid cell types with and without HIV infection.Q39745489
Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteinsQ39900720
Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cellsQ40161639
Cytokine patterns at the site of mycobacterial infectionQ40505087
Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease.Q41118171
Effects of morphine and morphine withdrawal on brainstem neurons innervating hypothalamic nuclei that control the pituitary-adrenocortical axis in ratsQ43032736
Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout miceQ43662399
Abrupt or precipitated withdrawal from morphine induces immunosuppressionQ44014891
Effect of naloxone-precipitated morphine withdrawal on CRH and vasopressin mRNA expression in the rat hypothalamic paraventricular nucleusQ44216438
Assessment of endogenous opioid mediation in stress-induced hypercholesterolemia in the rat.Q44343758
Withdrawal from morphine in mice suppresses splenic macrophage function, cytokine production, and costimulatory moleculesQ44641628
Paradoxes of immunosuppression in mouse models of withdrawalQ44740871
Morphine withdrawal sensitizes mice to lipopolysaccharide: elevated TNF-alpha and nitric oxide with decreased IL-12.Q46507475
Morphine withdrawal contributes to Th cell differentiation by biasing cells toward the Th2 lineageQ46635985
Splenic macrophages and B cells mediate immunosuppression following abrupt withdrawal from morphineQ46735687
Effects of morphine tolerance and abstinence on cellular immune functionQ48140969
Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-HydroxytryptamineQ49118851
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectlipopolysaccharideQ421804
morphineQ81225
P1104number of pages12
P304page(s)29806-29817
P577publication date2011-07-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleMorphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids
P478volume286

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cites work (P2860)
Q53637503A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53.
Q37227396CCL5 and cytokine expression in the rat brain: differential modulation by chronic morphine and morphine withdrawal
Q48904364Foxo3a transcriptionally upregulates AQP4 and induces cerebral edema following traumatic brain injury
Q40432327Gut Homeostasis, Microbial Dysbiosis, and Opioids
Q35952061Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms
Q55373987Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
Q36694953Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections
Q90378265Temporal and Site-Specific Changes in Central Neuroimmune Factors During Rapid Weight Gain After Ovariectomy in Rats
Q35977809The opioid antagonist, β-funaltrexamine, inhibits NF-κB signaling and chemokine expression in human astrocytes and in mice
Q89555422The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females
Q36703869Β-funaltrexamine inhibits chemokine (CXCL10) expression in normal human astrocytes

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