Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension

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Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1049431388
P356DOI10.1186/1465-9921-12-128
P932PMC publication ID3193170
P698PubMed publication ID21951574
P5875ResearchGate publication ID51666423

P50authorSteeve ProvencherQ92750879
P2093author name stringAudrey Courboulin
Jolyane Meloche
Roxane Paulin
Sébastien Bonnet
Malik Bisserier
Marjorie Barrier
Caroline Lambert
Maria Helena Jacob
Mathilde Chapolard
Véronique L Tremblay
P2860cites workKLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemiaQ24314374
MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formationQ24650539
Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathwayQ28115005
Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaBQ28211932
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodelingQ28213257
Significance of the transcription factor KLF5 in cardiovascular remodelingQ28267393
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growthQ28283339
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targetedQ28567772
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertensionQ28576675
STATs and gene regulationQ29547796
Primary pulmonary hypertension: a vascular biology and translational research "Work in progress".Q33145918
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertensionQ33329056
Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cellsQ33670426
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertensionQ33831900
Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodelingQ33930863
Reversal of experimental pulmonary hypertension by PDGF inhibitionQ34048479
Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotalineQ34095444
KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cellsQ34477034
Role for miR-204 in human pulmonary arterial hypertensionQ34681312
Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformationQ35112792
JANUS under stress--role of JAK/STAT signaling pathway in vascular diseasesQ36306876
The myocardial JAK/STAT pathway: from protection to failureQ37266843
KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilizationQ37285044
Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.Q37350177
Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques.Q37406383
Molecular mechanisms of pulmonary hypertensionQ37441315
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseasesQ37486142
A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertensionQ37702950
Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertensionQ37703654
Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cellsQ39821441
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.Q39834991
Kruppel-like factor 5 is required for perinatal lung morphogenesis and functionQ39965475
Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1.Q40359097
KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell lineQ40368983
Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cellsQ40421753
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertensionQ41123021
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) geneQ42440266
Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertensionQ42641623
Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertensionQ42737164
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.Q42809184
Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axisQ43276878
Imatinib for the treatment of pulmonary arterial hypertensionQ46726764
Endothelin receptor antagonists in pulmonary arterial hypertensionQ46779867
The antiproliferative effect of sildenafil on pulmonary artery smooth muscle cells is mediated via upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphorylationQ46979783
Inhibition of monocyte chemoattractant protein-1 by Krüppel-like factor 5 small interfering RNA in the tumor necrosis factor- alpha-activated human umbilical vein endothelial cellsQ47422549
Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2.Q47444169
Endothelin-1 is elevated in monocrotaline pulmonary hypertension.Q51476392
Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.Q53307573
Survivin gene expression in chronic liver disease and hepatocellular carcinoma.Q53500223
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?Q54299949
Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activationQ80385009
Expression of the anti-apoptotic factors Bcl-2 and survivin in canine vascular tumoursQ81275952
P407language of work or nameEnglishQ1860
P921main subjectarterial hypertensionQ41861
apoptotic processQ14599311
P304page(s)128
P577publication date2011-09-27
P1433published inRespiratory ResearchQ7315904
P1476titleKrüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
P478volume12

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