Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway

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Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1004734
P932PMC publication ID4214603
P698PubMed publication ID25356552
P5875ResearchGate publication ID267735513

P2093author name stringPaul J Cullen
Hema Adhikari
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinaseQ24291657
Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulatorQ24533167
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPKQ24598689
The transcriptional landscape of the yeast genome defined by RNA sequencingQ24633693
TopHat: discovering splice junctions with RNA-SeqQ24655505
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NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiaeQ24797402
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Regulation of mat responses by a differentiation MAPK pathway in Saccharomyces cerevisiaeQ27308564
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
Genomic expression programs in the response of yeast cells to environmental changesQ27860823
Positioning of cell growth and division after osmotic stress requires a MAP kinase pathway.Q27930462
Elements of the yeast pheromone response pathway required for filamentous growth of diploidsQ27930528
Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function.Q27930535
Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.Q27930567
A two-component system that regulates an osmosensing MAP kinase cascade in yeastQ27930757
Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiaeQ27930775
Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.Q27930940
Glucose depletion causes haploid invasive growth in yeastQ27931385
A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiaeQ27931403
The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiaeQ27931492
Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunitQ27931918
An osmosensing signal transduction pathway in yeast.Q27932086
The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiaeQ27932392
Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatasesQ27932501
Actin recovery and bud emergence in osmotically stressed cells requires the conserved actin interacting mitogen-activated protein kinase kinase kinase Ssk2p/MTK1 and the scaffold protein Spa2pQ27932526
MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.Q27932780
Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.Q27932838
Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeastQ27933036
Remodeling of yeast genome expression in response to environmental changesQ27933130
Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificityQ27933210
Stress-induced map kinase Hog1 is part of transcription activation complexes.Q27933281
MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiationQ27933379
The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections.Q27933508
A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and matingQ27933651
Bakers' yeast, a model for fungal biofilm formation.Q27933699
The MEK kinase Ssk2p promotes actin cytoskeleton recovery after osmotic stressQ27933780
Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodelingQ27933955
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factorQ27934014
Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeastQ27934033
PMI40, an intron-containing gene required for early steps in yeast mannosylationQ27934052
Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.Q27934994
Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.Q27936208
The septins: roles in cytokinesis and other processesQ27936270
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiaeQ27936490
Saccharomyces cerevisiae TEC1 is required for pseudohyphal growthQ27936711
Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RASQ27936756
Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiaeQ27936941
Combinatorial control required for the specificity of yeast MAPK signalingQ27937910
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeastQ27938083
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiaeQ27938825
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.Q27939105
Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growthQ27939215
Shedding of the mucin-like flocculin Flo11p reveals a new aspect of fungal adhesion regulationQ27939435
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.Q27939566
Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association.Q27939643
Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclinsQ27939854
Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathwayQ27939940
Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1.Q27940318
MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 geneQ27940377
A simple and efficient method for direct gene deletion in Saccharomyces cerevisiaeQ28131603
Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiaeQ28131610
Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferaseQ41607246
Two adjacent docking sites in the yeast Hog1 mitogen-activated protein (MAP) kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphataseQ41772137
The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans.Q41869795
Pheromone-induced morphogenesis improves osmoadaptation capacity by activating the HOG MAPK pathwayQ41879786
Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK.Q41920229
The HOG pathway dictates the short-term translational response after hyperosmotic shockQ42451574
Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 alleleQ42559192
The transcriptional response of yeast to saline stressQ42623210
Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditionsQ42738047
The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stressQ43069140
The high osmotic response and cell wall integrity pathways cooperate to regulate transcriptional responses to zymolyase-induced cell wall stress in Saccharomyces cerevisiaeQ43147138
Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiaeQ43181761
Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.Q43191422
Studies on phosphomannose isomerase. II. Characterization as a zinc metalloenzymeQ44215490
The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide.Q45968463
A yeast protein similar to bacterial two-component regulatorsQ46106065
A downshift in temperature activates the high osmolarity glycerol (HOG) pathway, which determines freeze tolerance in Saccharomyces cerevisiaeQ46863312
A conserved mitogen-activated protein kinase pathway is required for mating in Candida albicansQ48272020
Bypasses of the antimycin a block of mitochondrial electron transport in relation to ubisemiquinone function.Q50920269
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.Q54044321
Activation of the yeast cell wall integrity MAPK pathway by zymolyase depends on protease and glucanase activities and requires the mucin-like protein Hkr1 but not Msb2.Q54404891
Cross-talk and decision making in MAP kinase pathwaysQ58028841
The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashionQ73205031
Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin-permeabilized cells using flow cytometryQ73205704
Negative control of the Mig1p repressor by Snf1p-dependent phosphorylation in the absence of glucoseQ74384683
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1Q77993773
MAP kinase pathwaysQ81074052
Global gene deletion analysis exploring yeast filamentous growthQ84978517
Sense and sensibility: nutritional response and signal integration in yeastQ35958180
Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae.Q35965868
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activityQ36029564
Sphingolipids regulate the yeast high-osmolarity glycerol response pathwayQ36155090
The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cellsQ36171144
Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.Q36382575
MAPK signal specificity: the right place at the right timeQ36444123
Osmotic stress and the yeast cytoskeleton: phenotype-specific suppression of an actin mutationQ36531677
Genetics and genomics of Candida albicans biofilm formationQ36539594
Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutantsQ36544126
Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelityQ36556089
Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal developmentQ36690106
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stressQ36902914
A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae.Q37064006
Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stressQ37277581
The high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routesQ37773860
Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiaeQ37869191
The regulation of filamentous growth in yeastQ37973321
Response to hyperosmotic stressQ38048770
Leptin and vascular smooth muscle cellsQ38107983
Mitogen-activated protein kinase pathways in osteoblastsQ38110913
IRE1-dependent activation of AMPK in response to nitric oxideQ38960360
Carbon source-dependent phosphorylation of hexokinase PII and its role in the glucose-signaling response in yeast.Q39583995
The roles of bud-site-selection proteins during haploid invasive growth in yeastQ39640754
Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineeringQ39800927
The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicansQ39843038
Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymesQ39940956
A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicansQ39968804
Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiaeQ40366333
Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development.Q40388542
Transcriptional regulation in the yeast GAL gene family: a complex genetic networkQ40439061
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.Q40763964
Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinaseQ40813546
Glycoprotein biosynthesis in yeastQ40896550
Sir2 plays a key role in cell fate determination upon SAPK activation.Q40900716
The activity of yeast Hog1 MAPK is required during endoplasmic reticulum stress induced by tunicamycin exposureQ41192860
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
The septin cortex at the yeast mother-bud neckQ28208432
Identifying differentially expressed genes using false discovery rate controlling proceduresQ29615200
Osmotic stress signaling and osmoadaptation in yeastsQ29617597
A yeast gene that is essential for release from glucose repression encodes a protein kinaseQ29620532
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profilesQ29620701
N-acetylglucosamine-inducible CaGAP1 encodes a general amino acid permease which co-ordinates external nitrogen source response and morphogenesis in Candida albicansQ33188344
The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancerQ33412131
An extensive circuitry for cell wall regulation in Candida albicansQ33530089
Dimorphism and virulence in Candida albicansQ33538707
Glucose repression in yeastQ33632468
Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasisQ33754752
Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiaeQ33781305
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Isogenic strain construction and gene mapping in Candida albicans.Q33961115
Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiaeQ33962945
Structure and function of enzymes of the Leloir pathway for galactose metabolismQ33967795
Genome-wide survey of yeast mutations leading to activation of the yeast cell integrity MAPK pathway: novel insights into diverse MAPK outcomes.Q33978987
Signal transduction cascades regulating fungal development and virulence.Q34010291
Pheromone response, mating and cell biologyQ34106610
Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cellsQ34215123
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammalsQ34245400
Regulation of G protein-initiated signal transduction in yeast: paradigms and principlesQ34275492
Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transductionQ34278972
Cell cycle control of yeast filamentous growth.Q34455368
Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutantsQ34608075
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membraneQ34673029
The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiaeQ35065482
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathwayQ35620450
Unique and Redundant Roles for HOG MAPK Pathway Components as Revealed by Whole-Genome Expression AnalysisQ35796834
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
edgeRQ113334690
P433issue10
P304page(s)e1004734
P577publication date2014-10-30
P1433published inPLOS GeneticsQ1893441
P1476titleMetabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway
P478volume10

Reverse relations

cites work (P2860)
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