MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease

scientific article

MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.3883-11.2011
P932PMC publication ID3200297
P698PubMed publication ID21994399
P5875ResearchGate publication ID51714525

P2093author name stringChristina Chan
Hirosha Geekiyanage
P2860cites workExpression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiationQ21194851
Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type IQ24301846
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
MicroRNAs: small RNAs with a big role in gene regulationQ27860896
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosisQ28139061
A detergent-insoluble membrane compartment contains A beta in vivoQ47982783
Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse modelQ48194870
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampusQ48266570
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse modelQ48877805
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.Q48933018
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham StudyQ53295392
Ceramide and sphingomyelin species of fibroblasts and neurons in cultureQ57375110
Ketogenic diet in Rett syndromeQ73184781
Molecular genetics of Alzheimer's diseaseQ77910325
Principles of bioactive lipid signalling: lessons from sphingolipidsQ28265743
Spatial segregation of gamma-secretase and substrates in distinct membrane domainsQ28591973
A brain-specific microRNA regulates dendritic spine developmentQ29614753
Meta-analysis of linkage studies for Alzheimer's disease--a web resourceQ30484112
Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspringQ33511008
Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-betaQ33605734
Deregulation of sphingolipid metabolism in Alzheimer's diseaseQ33693061
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.Q33722837
Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neuronsQ33762153
Cross talk between microRNA and epigenetic regulation in adult neurogenesisQ33788417
Context-dependent functions of specific microRNAs in neuronal developmentQ34220566
Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's diseaseQ34489852
Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferaseQ34571804
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor proteinQ34649008
Ceramide structure predicts tumor ganglioside immunosuppressive activityQ35084457
Non-coding RNAs in the nervous systemQ36523588
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's diseaseQ36604677
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expressionQ36609033
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brainQ37379675
MicroRNAs in brain development and physiologyQ37619095
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.Q38291637
Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice.Q38321708
miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma.Q39674586
Identification of gliotropic factors that induce human stem cell migration to malignant tumorQ39863377
Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid raftsQ39938837
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathwaysQ39975165
Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signalingQ40625434
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegansQ41914523
A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.Q42177453
Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2.Q42183157
Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activitiesQ42507824
Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3.Q43143033
Brain membrane phospholipid alterations in Alzheimer's diseaseQ43743686
Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesisQ44163309
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesisQ44370232
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient miceQ45182276
Therapeutic effects of a ketogenic diet in Rett syndromeQ46156332
Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin.Q46335285
Alzheimer peptides perturb lipid-regulating enzymesQ46873173
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
microRNAQ310899
P304page(s)14820-14830
P577publication date2011-10-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleMicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease
P478volume31

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