Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein

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Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.626903
P932PMC publication ID4400358
P698PubMed publication ID25724652

P50authorRoger G PtakQ90694284
Dana GabuzdaQ91131980
Marie K MankowskiQ115679026
Vikas MisraQ124366716
Erez PeryQ124366726
Ann SheehyQ124366729
N Miranda NebaneQ124366730
P2093author name stringE Lucile White
Lynn Rasmussen
Sara J Buhrlage
Andrew Jay Brazier
Kottampatty S Rajendran
P2860cites workT-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restrictionQ24300389
The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNAQ24305266
Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F.Q24544264
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replicationQ24563503
A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletionQ24568052
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agentQ24656023
Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assemblyQ24658171
Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidationQ24672209
Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cellsQ24796626
Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversificationQ24817186
Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retrovirusesQ25257798
Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding DomainQ27678176
Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3FQ27680506
The APOBEC3C crystal structure and the interface for HIV-1 Vif bindingQ27682427
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcriptsQ28179446
DNA deamination mediates innate immunity to retroviral infectionQ28179534
Species-specific exclusion of APOBEC3G from HIV-1 virions by VifQ28187133
HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular StabilityQ28207304
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replicationQ28286241
The role of mononuclear phagocytes in HTLV-III/LAV infectionQ29618676
HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradationQ29618937
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 VifQ29618938
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.Q30333471
The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivityQ31011512
Identification of 81LGxGxxIxW89 and 171EDRW174 domains from human immunodeficiency virus type 1 Vif that regulate APOBEC3G and APOBEC3F neutralizing activity.Q33877364
Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3GQ33883514
Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligaseQ33908716
Identification of a critical T(Q/D/E)x5ADx2(I/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity.Q34055413
Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC.Q34179686
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infectionQ34242229
Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.Q34651619
Zinc binding to the HCCH motif of HIV-1 virion infectivity factor induces a conformational change that mediates protein-protein interactions.Q35214620
Role of Vif in human immunodeficiency virus type 1 reverse transcriptionQ35873743
Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formationQ35914312
Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F.Q35947612
The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA.Q36099305
Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.Q36315163
The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restrictionQ36484144
APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophagesQ36506765
Suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4(+) T cells is associated with inhibition of processive reverse transcription as well as excessive cytidine deaminationQ36559921
Subcellular localization of the Vif protein of human immunodeficiency virus type 1.Q36626506
APOBEC-mediated viral restriction: not simply editing?Q36736677
A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factorQ37094645
A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).Q37095343
Regulation of APOBEC3 proteins by a novel YXXL motif in human immunodeficiency virus type 1 Vif and simian immunodeficiency virus SIVagm VifQ37099703
Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif.Q37153444
Small-molecule inhibition of HIV-1 Vif.Q37218625
Structure-guided analysis of the human APOBEC3-HIV restrictomeQ38198378
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.Q39405160
Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis.Q39596337
Identification of amino acid residues in HIV-1 Vif critical for binding and exclusion of APOBEC3G/F.Q39964772
Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G.Q40202838
Antiviral potency of APOBEC proteins does not correlate with cytidine deaminationQ40243154
A zinc-binding region in Vif binds Cul5 and determines cullin selectionQ40288287
APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.Q40464899
Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteinesQ40485825
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradationQ40485830
Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localizationQ40493589
Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expressionQ40579791
A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif actionQ40589617
Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathwayQ40607865
Characterization of an HIV-1 Isolate Displaying an Apparent Absence of Virion-Associated Reverse Transcriptase ActivityQ41691433
Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G bindingQ42910736
The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3GQ44653976
HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradationQ45195765
Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activityQ45236572
Genetic analysis of HIV-1 isolates from Brazil reveals presence of two distinct genetic subtypesQ48083097
Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanismQ73422734
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)10504-10517
P577publication date2015-02-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein
P478volume290

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cites work (P2860)
Q395148175-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2'-Deoxycytidine.
Q52612280A New Class of Antiretroviral Enabling Innate Immunity by Protecting APOBEC3 from HIV Vif-Dependent Degradation.
Q39156048A Review of Functional Motifs Utilized by Viruses.
Q45324625APOBEC Enzymes as Targets for Virus and Cancer Therapy.
Q28081195APOBEC3 Interference during Replication of Viral Genomes
Q51011655An improved method for purification and refolding of recombinant HIV Vif expressed in Escherichia coli.
Q47229846Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors
Q83224530Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q55380693Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation.
Q36158234Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis
Q35682519Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1.
Q92651101Regulation of Antiviral Innate Immunity Through APOBEC Ribonucleoprotein Complexes
Q60046078Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1
Q47568875Viral subversion of APOBEC3s: Lessons for anti-tumor immunity and tumor immunotherapy

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