Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.

scientific article

Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/NP200324X
P953full work available at URLhttps://europepmc.org/articles/pmc3204160?pdf=render
P932PMC publication ID3204160
P698PubMed publication ID21793558
P5875ResearchGate publication ID51525239

P7228access restriction statusopen accessQ232932
P50authorFranz-Josef Meyer-AlmesQ58808021
P2093author name stringMin He
Cheng Wang
Yi-Qiang Cheng
Difei Wang
Leonhard M Henkes
Leah B Doughty
P2860cites workRegulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modificationsQ24324035
An improved method for rapid generation of unmarked Pseudomonas aeruginosa deletion mutantsQ24815663
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies.Q25256563
Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like speciesQ28267499
The epigenomics of cancerQ28289975
A new enzyme superfamily - the phosphopantetheinyl transferasesQ28297964
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesisQ28505748
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3Q28609763
The NCI60 human tumour cell line anticancer drug screenQ29614975
Natural products as sources of new drugs over the last 25 yearsQ29615119
Anticancer activities of histone deacetylase inhibitorsQ29616624
FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphomaQ33377159
Automated genome mining for natural products.Q33468697
Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.Q33652301
Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell linesQ33843555
Natural products version 2.0: connecting genes to molecules.Q34096062
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activityQ34291658
Class II histone deacetylases: structure, function, and regulationQ34316258
Biosynthesis of nonribosomal peptides1.Q34359384
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.Q34555236
Developmental therapeutics program at the NCI: molecular target and drug discovery processQ34605253
Histone deacetylase inhibitors in cancer therapyQ34659283
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisQ34867101
Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968Q35913058
Epigenetic therapy of cancer: past, present and futureQ36399557
Impact of natural products on developing new anti-cancer agentsQ37473373
Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implicationsQ37512907
Rational combinations using HDAC inhibitorsQ37512911
New natural product biosynthetic chemistry discovered by genome miningQ37564018
Histone deacetylase inhibitors: current status and overview of recent clinical trialsQ37595483
New patented histone deacetylase inhibitorsQ37638742
Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthaseQ41881191
New insights into the genetic organization of the FK228 biosynthetic gene cluster in Chromobacterium violaceum no. 968.Q41896840
Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensisQ41943701
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylasesQ44123685
An FAD-dependent pyridine nucleotide-disulfide oxidoreductase is involved in disulfide bond formation in FK228 anticancer depsipeptideQ44364265
Improved fluorogenic histone deacetylase assay for high-throughput-screening applicationsQ44597699
Application of the four-parameter logistic model to bioassay: comparison with slope ratio and parallel line modelsQ45085984
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.Q52526450
Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor CellsQ57956100
StatBite: FDA oncology drug product approvals in 2009Q82847378
P433issue10
P921main subjectChromobacterium violaceumQ3498295
(1S,5S,6R,9S,20R)-6-butan-2-yl-20-butyl-5-hydroxy-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetroneQ105172590
(1S,5S,6R,9S,20R)-6-butan-2-yl-5-hydroxy-20-(2-methylsulfanylethyl)-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetroneQ105287567
P6954online access statusopen accessQ232932
P304page(s)2031-2038
P577publication date2011-07-27
P1433published inJournal of Natural ProductsQ165584
P1476titleThailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities
P478volume74

Reverse relations

cites work (P2860)
Q38285290An overview of naturally occurring histone deacetylase inhibitors.
Q41712392Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1.
Q41728195Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus
Q31085256Burkholderia: an update on taxonomy and biotechnological potential as antibiotic producers
Q36237655Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94.
Q35213063Computational design of a time-dependent histone deacetylase 2 selective inhibitor
Q38162900Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications
Q42390498Cyclo-(-l-prolyl-l-valinyl-) from Burkholderia thailandensis MSMB43.
Q38604510Direct Capture Technologies for Genomics-Guided Discovery of Natural Products
Q42575294Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264.
Q35998436Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer
Q64080782Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells
Q89694380Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters
Q51450941Extractive fermentation for enhanced production of thailandepsin A from Burkholderia thailandensis E264 using polyaromatic adsorbent resin Diaion HP-20.
Q42323574FK228 from Burkholderia thailandensis MSMB43.
Q45269243Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns
Q38258173Genome mining: concept and strategies for natural product discovery.
Q37625346Genome-guided discovery of diverse natural products from Burkholderia sp.
Q58700133Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228
Q36966213Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43
Q37151868HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
Q36913610HDAC6 and ovarian cancer
Q95853354Histone Deacetylase Inhibitors: A Prospect in Drug Discovery
Q42378482Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo
Q35474016Histone deacetylase inhibitors from Burkholderia thailandensis
Q90568487Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid
Q34051299Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator
Q44119688Improved production of cytotoxic thailanstatins A and D through metabolic engineering of Burkholderia thailandensis MSMB43 and pilot scale fermentation
Q37521291Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance
Q42176778KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy
Q27007021Lessons learned from the transformation of natural product discovery to a genome-driven endeavor
Q36331476Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
Q51669780Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis.
Q55396456Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968.
Q47740361Natural Agents-Mediated Targeting of Histone Deacetylases.
Q28073020Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer
Q38982458Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes
Q36253534Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds
Q38762222Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals.
Q91776959Origin and bioactivities of thiosulfinated FK228
Q91836053Peptides as epigenetic modulators: therapeutic implications
Q92519228Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors
Q36319273Quantitative structure-activity relationship analysis and virtual screening studies for identifying HDAC2 inhibitors from known HDAC bioactive chemical libraries
Q36152864Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation
Q91853497Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro
Q34503961Target engagement and drug residence time can be observed in living cells with BRET.
Q89143122Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene
Q35963760Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy
Q40023916Thailandepsin a.
Q36088241Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy
Q33776640The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growth
Q27681843The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis
Q33659166The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancer