The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages

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The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9k4914P
P356DOI10.1371/JOURNAL.PONE.0114914
P932PMC publication ID4259488
P698PubMed publication ID25485627
P5875ResearchGate publication ID269282048

P50authorYousef Abu KwaikQ92634282
Christopher T D PriceQ124758881
P2860cites workMyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infectionQ57217265
Arginine Transport Is Impaired in C57Bl/6 Mouse Macrophages as a Result of a Deletion in the Promoter of Slc7a2 (CAT2), and Susceptibility to Leishmania Infection Is ReducedQ61759625
IL-10 enhances the growth of Legionella pneumophila in human mononuclear phagocytes and reverses the protective effect of IFN-gamma: differential responses of blood monocytes and alveolar macrophagesQ71527764
Na+-dependent high-affinity glutamate transport in macrophagesQ73755966
Murine macrophages differentially produce proinflammatory cytokines after infection with virulent vs. avirulent Legionella pneumophilaQ73904775
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infectionQ82412798
Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoaQ21131567
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticityQ22122047
Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein familyQ24677004
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunityQ25257710
Emerging roles for lysophosphatidylserine in resolution of inflammationQ26864795
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Role of glutamate transporters in the regulation of glutathione levels in human macrophagesQ28204159
Principles of bioactive lipid signalling: lessons from sphingolipidsQ28265743
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophilaQ28474072
Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functionsQ28485639
Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cellsQ28506473
Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophagesQ28584905
Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosisQ28586062
Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseQ29616156
Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epitheliaQ30429958
Legionella eukaryotic-like type IV substrates interfere with organelle traffickingQ33356625
Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinaseQ33373341
LnaB: a Legionella pneumophila activator of NF-kappaB.Q33530689
Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.Q33650603
Legionella pneumophila evades gamma interferon-mediated growth suppression through interleukin-10 induction in bone marrow-derived macrophagesQ33768899
Cationic amino acid transporters and Salmonella Typhimurium ArgT collectively regulate arginine availability towards intracellular Salmonella growthQ33769496
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector.Q33769572
Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.Q33841951
Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophilaQ33847063
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophilaQ33877241
The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokinesQ33946169
Transient transgenic expression of gamma interferon promotes Legionella pneumophila clearance in immunocompetent hostsQ34009414
Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophilaQ34044433
Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.Q34110701
E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substratesQ34119372
The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking.Q34181343
Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress responseQ34257036
Identification of two Legionella pneumophila effectors that manipulate host phospholipids biosynthesisQ34468990
Exploitation of evolutionarily conserved amoeba and mammalian processes by LegionellaQ34637388
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerizationQ34638759
Striking a balance: modulation of host cell death pathways by legionella pneumophila.Q35028575
Targeting One of its Own: Expanding Roles of Substrates of the Legionella Pneumophila Dot/Icm Type IV Secretion System.Q35028618
Host-mediated post-translational prenylation of novel dot/icm-translocated effectors of legionella pneumophilaQ35028893
Exploitation of Host Polyubiquitination Machinery through Molecular Mimicry by Eukaryotic-Like Bacterial F-Box EffectorsQ35029058
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infectionQ35060264
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.Q35130836
Anchors for effectors: subversion of phosphoinositide lipids by legionella.Q35155317
A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell deathQ35161315
Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansionQ35202685
Legionella pneumophila-induced NF-kappaB- and MAPK-dependent cytokine release by lung epithelial cellsQ43965912
Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosomeQ44695321
Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5.Q45273584
Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentationQ47815851
Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophilaQ48269403
Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organsQ48462591
Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages.Q53229775
Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia.Q54441180
Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial GrowthQ56806827
In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxideQ35433678
L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophagesQ35913502
Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumoniaQ35923195
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila.Q36228869
IL-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivoQ36929384
Legionella pneumophila inhibits protein synthesis in Chinese hamster ovary cellsQ36959611
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitorsQ37310577
The Legionella pneumophila replication vacuole: making a cosy niche inside host cellsQ37326393
The perplexing functions and surprising origins of Legionella pneumophila type IV secretion effectors.Q37534884
Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophilaQ37582843
Emerging role for the cytoskeleton as an organizer and regulator of translationQ37660896
A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerizationQ37662800
Effector glycosyltransferases in legionellaQ37915288
Legionella secreted effectors and innate immune responses.Q37943875
Cellular microbiology and molecular ecology of Legionella-amoeba interactionQ38093720
Phosphoinositide lipids and the Legionella pathogen vacuoleQ38126839
Modulation of the ubiquitination machinery by Legionella.Q38126841
Host lipidation: a mechanism for spatial regulation of Legionella effectors.Q38126842
Amoeba host-Legionella synchronization of amino acid auxotrophy and its role in bacterial adaptation and pathogenic evolutionQ38151206
Make yourself at home: viral hijacking of the PI3K/Akt signaling pathwayQ38172352
Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cellQ38228145
Interaction of LRRK2 with kinase and GTPase signaling cascadesQ38234885
Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages.Q38438441
Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.Q39079755
Serum cytokines in patients with Legionella pneumonia: relative predominance of Th1-type cytokinesQ39552195
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.Q39722305
Temporal resolution of two-tracked NF-kappaB activation by Legionella pneumophilaQ39830075
A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria.Q39852238
Sequential interplay between BAG6 and HSP70 upon heat shockQ39862448
The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.Q39914102
Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophilaQ40012199
Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot/Icm systemQ40068268
Anti-apoptotic signalling by the Dot/Icm secretion system of L. pneumophilaQ40243451
Cutting edge: microbial products elicit formation of dendritic cell aggresome-like induced structures in macrophages.Q40455138
The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuoleQ41851030
Rapid nutritional remodeling of the host cell upon attachment of Legionella pneumophilaQ41909309
Incomplete activation of macrophage apoptosis during intracellular replication of Legionella pneumophila.Q42142487
A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa.Q42175516
Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophagesQ42727278
Isotopologue profiling of Legionella pneumophila: role of serine and glucose as carbon substratesQ42733806
Amino Acid Uptake and Metabolism of Legionella pneumophila Hosted by Acanthamoeba castellaniiQ42747872
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectLegionella pneumophilaQ147885
transcriptomeQ252857
P304page(s)e114914
P577publication date2014-12-08
P1433published inPLOS OneQ564954
P1476titleThe transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages
P478volume9

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cites work (P2860)
Q38684839A gyrB oligonucleotide microarray for the specific detection of pathogenic Legionella and three Legionella pneumophila subsp
Q37123434Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures
Q38774349Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.
Q28087165Host Delivery of Favorite Meals for Intracellular Pathogens
Q38631456Identification of regions within the Legionella pneumophila VipA effector protein involved in actin binding and polymerization and in interference with eukaryotic organelle trafficking.
Q91862887Investigation of the host transcriptional response to intracellular bacterial infection using Dictyostelium discoideum as a host model
Q99712061Legionella pneumophila Infection Rewires the Acanthamoeba castellanii Transcriptome, Highlighting a Class of Sirtuin Genes
Q30827147Legionella pneumophila prevents proliferation of its natural host Acanthamoeba castellanii
Q90709433Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
Q26765923Purinergic Signaling to Terminate TLR Responses in Macrophages
Q35609372Selective requirement of the shikimate pathway of Legionella pneumophila for intravacuolar growth within human macrophages but not within Acanthamoeba

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