Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation

scientific article published on 21 September 2011

Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.05661-11
P932PMC publication ID3209388
P698PubMed publication ID21937654

P2093author name stringThornton W Thompson
Malen A Link
Lisa A Pitcher
David J Davido
Heba H Mostafa
Adam M Bayless
Steve D Haenchen
Priscilla A Schaffer
Anna S Kushnir
Emma Loveday
Joshua G Hilliard
P2860cites workPML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0Q24298207
Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expressionQ24298241
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruptionQ24527246
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteinsQ24630637
Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complexQ24675640
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5aQ24678629
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Characterization of the IE110 gene of herpes simplex virus type 1Q28287831
Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localizeQ28345181
A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defenceQ28477120
State and role of SRC family kinases in replication of herpes simplex virus 1.Q30159875
Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfacesQ30160269
Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitroQ39686108
Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxxQ39741152
Epigenetic modulation of gene expression from quiescent herpes simplex virus genomesQ39836698
Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.Q40030711
Histone modifications associated with herpes simplex virus type 1 genomes during quiescence and following ICP0-mediated de-repressionQ40033809
Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cellsQ40065340
Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.Q40373883
The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/betaQ40745643
Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type-1.Q41225801
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activityQ41587905
Reversal of heterochromatic silencing of quiescent herpes simplex virus type 1 by ICP0.Q41933341
Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in miceQ42147484
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiaeQ42642323
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.Q44509784
Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteinsQ45751210
Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0).Q45777008
Temperature-sensitive mutants of herpes simplex virus type 1: isolation, complementation and partial characterizationQ45817912
Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110.Q45835577
Construction and characterization of herpes simplex virus type 1 mutants with defined lesions in immediate early gene 1.Q45845827
Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signalingQ46122037
RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neuronsQ68986775
The UL13 protein kinase and the infected cell type are determinants of posttranslational modification of ICP0Q73661488
Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responsesQ33573566
The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoformsQ33783492
Herpes simplex virus ICP0 mutants are hypersensitive to interferonQ33798242
Optimized viral dose and transient immunosuppression enable herpes simplex virus ICP0-null mutants To establish wild-type levels of latency in vivoQ33806643
ICP0 is required for efficient reactivation of herpes simplex virus type 1 from neuronal latencyQ33838198
Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spreadQ33851697
Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymesQ33894274
Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA.Q33911883
B7 costimulation molecules encoded by replication-defective, vhs-deficient HSV-1 improve vaccine-induced protection against corneal diseaseQ33985984
Point mutations in herpes simplex virus type 1 oriL, but not in oriS, reduce pathogenesis during acute infection of mice and impair reactivation from latencyQ34233084
The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0.Q34330457
Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1.Q34356255
Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infectionQ34848465
ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latencyQ35013167
The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27Q35886888
Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivoQ36367805
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.Q36655446
Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon productionQ36684310
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latencyQ36780729
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutantsQ36782886
Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA.Q36831483
Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell cultureQ36885629
Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodiesQ36894567
Herpes simplex virus type 1 ICP0 phosphorylation mutants impair the E3 ubiquitin ligase activity of ICP0 in a cell type-dependent mannerQ36949684
The Differential Requirement for Cyclin-Dependent Kinase Activities Distinguishes Two Functions of Herpes Simplex Virus Type 1 ICP0Q37060135
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.Q37116670
The role of cdc2 in the expression of herpes simplex virus genesQ37269688
Re-evaluating natural resistance to herpes simplex virus type 1.Q37492787
Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase geneQ37527308
Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesisQ37683002
Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 functionQ37743081
Specification of SUMO1- and SUMO2-interacting motifsQ38315174
Activities of ICP0 involved in the reversal of silencing of quiescent herpes simplex virus 1.Q39575218
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)12631-12637
P577publication date2011-09-21
P1433published inJournal of VirologyQ1251128
P1476titleHerpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation
P478volume85

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cites work (P2860)
Q36306971A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro
Q64108733Attenuated infectious laryngotracheitis virus vaccines differ in their capacity to establish latency in the trigeminal ganglia of specific pathogen free chickens following eye drop inoculation
Q33883877HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity
Q47555886Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation
Q37336866Herpes simplex virus 1 ICP22 but not US 1.5 is required for efficient acute replication in mice and VICE domain formation
Q39796290Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons
Q26766356Infected cell protein 0 functional domains and their coordination in herpes simplex virus replication
Q36607356N-terminal phosphorylation sites of herpes simplex virus 1 ICP0 differentially regulate its activities and enhance viral replication
Q94951027The HSV-1 ubiquitin ligase ICP0: modifying the cellular proteome to promote infection
Q37336832Two overlapping regions within the N-terminal half of the herpes simplex virus 1 E3 ubiquitin ligase ICP0 facilitate the degradation and dissociation of PML and dissociation of Sp100 from ND10.

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