An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen

scientific article published on October 1998

An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/THX.53.10.849
P932PMC publication ID1745083
P698PubMed publication ID10193371
P5875ResearchGate publication ID13105543

P2093author name stringFoster PS
Shepherd DP
Hogan SP
Kumar RK
Temelkovski J
P2860cites workEosinophilic Inflammation in AsthmaQ29031455
Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsivenessQ33665320
Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthmaQ35996490
Pathology of asthmaQ36262188
Asthma. Epithelial cellsQ36262224
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma modelQ36366104
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.Q36366158
Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulinsQ37365236
Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowingQ38643107
Animal models of occupational asthmaQ40662563
Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.Q40768651
Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity.Q40791336
The relevance of murine animal models to study the development of allergic bronchial asthmaQ41046427
Pathology of mild, severe, and fatal asthmaQ41075223
"Ultimate activation" of eosinophils in vivo: lysis and release of clusters of free eosinophil granules (Cfegs)Q41535089
Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient miceQ42947781
Effect of acute and chronic antigen inhalation on airway morphology and responsiveness in actively sensitized ratsQ44165838
Attenuation of allergic airway inflammation in IL-4 deficient miceQ49112216
Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjectsQ49280491
Airway mucosal inflammation even in patients with newly diagnosed asthma.Q51670975
Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice.Q54155075
Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats.Q54185709
Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse.Q54268935
Susceptibility to experimental interstitial lung disease is modified by immune- and non-immune-related genes.Q54413019
Airway reactivity in ponies with recurrent airway obstruction (heaves).Q54455049
Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized Brown-Norway ratsQ57085092
Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cellsQ59310681
Relationship between IL-4 and IL-5 mRNA Expression and Disease Severity in Atopic AsthmaQ61895278
AsthmaQ67595530
Endotoxins in inhalation research. Summary of conclusions of a workshop held at Clearwater, Florida, U.S.A., 28-30 September 1987Q68035689
Toward a definition of asthma for epidemiologyQ68037965
The mechanics of airway narrowing in asthmaQ69938618
Cellular events in the bronchi in mild asthma and after bronchial provocationQ69960302
Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in miceQ70511277
Enzyme complex amplification--a signal amplification method for use in enzyme immunoassaysQ70642555
The role of 5-lipoxygenase products in preclinical models of asthmaQ70660902
Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigenQ70684112
Lung inflammation and epithelial changes in a murine model of atopic asthmaQ71065076
Measurement of low-frequency respiratory impedance in infantsQ71189405
Mouse models of allergic disease; how do they relate to asthma in man?Q71538074
Alveolar tissue inflammation in asthmaQ71767468
Seasonal comparison of cytokine profiles in atopic asthmatics and atopic non-asthmaticsQ71906919
Characterization of a murine model of allergic pulmonary inflammationQ72190775
Detection of cytokines and their cell sources in bronchial biopsy specimens from asthmatic patients. Relationship to atopic status, symptoms, and level of airway hyperresponsivenessQ72300760
Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric studyQ72918050
Monocyte chemotactic protein-3 (MCP-3)/fibroblast-induced cytokine (FIC) in eosinophilic inflammation of the airways and the inhibitory effects of an anti-MCP-3/FIC antibodyQ73326142
Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammationQ73359111
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmographyQ73730758
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectasthmaQ35869
murine modelQ122890741
P304page(s)849-856
P577publication date1998-10-01
P1433published inThoraxQ7796158
P1476titleAn improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen
P478volume53

Reverse relations

cites work (P2860)
Q459816141,25-Dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) attenuates airway remodeling in a murine model of chronic asthma.
Q47100403A 3D epithelial-mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment.
Q43423470Absence of respiratory inflammatory reaction of elemental sulfur using the California Pesticide Illness Database and a mouse model
Q37137320Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment
Q46027211Airway fibrosis in a mouse model of airway inflammation.
Q37657084Airway remodeling in asthma: what really matters
Q35878502Airway remodeling: lessons from animal models
Q39670944Airway responsiveness after acute exposure to urban particulate matter 1648 in a DO11.10 murine model
Q48029209Airway smooth muscle cells from ovalbumin-sensitized mice show increased proliferative response to TGFβ1 due to upregulation of Smad3 and TGFβRII.
Q34206747Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice.
Q33934140Aligning mouse models of asthma to human endotypes of disease
Q33909356Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target
Q34162303Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma
Q28652444Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33
Q37105629An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice
Q35484382Angiotensin-(1-7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation
Q43065050Animal models of chronic experimental asthma - strategies for the identification of new therapeutic targets
Q28540323Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: association with inhibition of histone acetylation
Q35607608Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128.
Q55485718Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1/Th2 Immune Response.
Q36282984Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?
Q39287243Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
Q44086872Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma: protection by inhaled steroids
Q29248141Barriers to inhaled gene therapy of obstructive lung diseases: A review
Q83892144Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma
Q36062587Building better mouse models of asthma
Q43957822CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma.
Q51110441Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma.
Q35745429Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus
Q57203119Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling
Q38781893Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance.
Q43997164Cigarette smoke-induced airway hyperresponsiveness is not dependent on elevated immunoglobulin and eosinophilic inflammation in a mouse model of allergic airway disease
Q43719593Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease
Q27332407Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model
Q33977282Consequences of long-term inflammation. Airway remodeling
Q44641935Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
Q37260860Cumulative environmental changes, skewed antigen exposure, and the increase of allergy
Q34903133Cytokine/anti-cytokine therapy - novel treatments for asthma?
Q33733234Delivery of adipose-derived mesenchymal stem cells attenuates airway responsiveness and inflammation in a mouse model of ovalbumin-induced asthma
Q54528175Depletion of CD8+ T cells enhances airway remodelling in a rodent model of asthma.
Q33514105Derivation and validation of murine histologic alterations resembling asthma, with two proposed histologic grade parameters
Q36683087Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge
Q51692395Development of sensitisation or tolerance following repeated OVA inhalation in BALB/cJ mice. Dose-dependency and modulation by the Al(OH)3 adjuvant.
Q73833089Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma
Q33741672Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
Q36953178Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic mice
Q51279385Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma.
Q34687375Effect of physical training on airway inflammation in animal models of asthma: a systematic review
Q46490838Effect of tranilast in comparison with beclomethasone in chronic murine model of asthma
Q53365576Effect of β-glucan originated from Aureobasidium pullulans on asthma induced by ovalbumin in mouse.
Q58049795Effects of the Histone Deacetylase Inhibitor, Trichostatin A, in a Chronic Allergic Airways Disease Model in Mice
Q46319705Efficacy of sulphasalazine on lung histopathology in a murine model of chronic asthma
Q77932340Eotaxin expression by epithelial cells and plasma cells in chronic asthma
Q38056181Exposure of immunologically naive laboratory rodents to antigen via the airways. Where does tolerance stop and sensitization begin?
Q36238055Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma
Q48623458Fractionated irradiations lead to chronic allergic airway inflammation through increasing the influx of macrophages
Q37943847Fungi linking the pathophysiology of chronic rhinosinusitis with nasal polyps and allergic asthma
Q51703541General and Specific Mouse Models for Asthma Research.
Q37642503Glycyrrhizin and long-term histopathologic changes in a murine model of asthma
Q37321867HSP70/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthma
Q35125317ISU201 enhances the resolution of airway inflammation in a mouse model of an acute exacerbation of asthma.
Q35864971Immunolocalization of NLRP3 Inflammasome in Normal Murine Airway Epithelium and Changes following Induction of Ovalbumin-Induced Airway Inflammation
Q37144545Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure
Q46052640In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model
Q37596511In utero exposure to second-hand smoke aggravates the response to ovalbumin in adult mice
Q45763812Influence of inhaled beclomethasone and montelukast on airway remodeling in mice
Q81470399Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
Q35884617Initial observations of cell-mediated drug delivery to the deep lung
Q42181941Interleukin-33 drives activation of alveolar macrophages and airway inflammation in a mouse model of acute exacerbation of chronic asthma
Q77856796Interleukin-5 and eosinophils as therapeutic targets for asthma
Q51121563Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease.
Q51662353Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model.
Q36081902Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model
Q58795805Intratracheal administration of adipose derived mesenchymal stem cells alleviates chronic asthma in a mouse model
Q42530785Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins
Q39402859Modeling TH 2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma
Q34805236Modeling allergic asthma in mice: pitfalls and opportunities
Q51653665Morphometric analysis of mouse airways after chronic allergen challenge.
Q26765990Mouse models of acute exacerbations of allergic asthma
Q34212495Mouse models of allergic airway disease
Q37353895Mouse models of allergic asthma: acute and chronic allergen challenge
Q39237092Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation
Q37809217Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance
Q34192921Murine model of chronic human asthma.
Q37859521Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease.
Q41891749Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent
Q42261660Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression
Q36193355Overexpression of programmed cell death 5 in a mouse model of ovalbumin-induced allergic asthma
Q43991324PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model
Q47767965Penh is not a validated technique for measuring airway function in mice
Q37754996Preclinical animal models of asthma and chronic obstructive pulmonary disease
Q33872051Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice
Q78850530Proceedings of the first Jack Pepys Occupational Asthma Symposium
Q56834648Profibrotic Effect of IL-9 Overexpression in a Model of Airway Remodeling
Q36193173Prolonged allergen challenge in mice leads to persistent airway remodelling.
Q49169342Prolonged allergen exposure induces structural airway changes in sensitized rats
Q43162277Prolonged ovalbumin challenge facilitates Th17 polarization in sensitized mice
Q25256965Prolonged ozone exposure in an allergic airway disease model: adaptation of airway responsiveness and airway remodeling
Q97420223Proteomics profiling asthma induced-lysine acetylation
Q28573585Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide
Q24804158Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling
Q36573298Recurring BALB/c mouse lung inflammatory responses to episodic allergen exposure
Q33318473Reduced lung function in a chronic asthma model is associated with prolonged inflammation, but independent of peribronchial fibrosis
Q46375181Repeated inhalation challenge with diphenylmethane-4,4'-diisocyanate in brown Norway rats leads to a time-related increase of neutrophils in bronchoalveolar lavage after topical induction
Q39042664Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma
Q36159665Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease
Q43100120Reversal of methylprednisolone effects in allergen-exposed female BALB/c mice
Q38864968Review of Mouse Models Applied to the Study of Asthma
Q42393166Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses
Q40485763Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle
Q28534642Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation
Q37423130Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond
Q41557551Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
Q36623919Sinomenine attenuates airway inflammation and remodeling in a mouse model of asthma
Q92130987Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation
Q37098449Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma
Q89621756Study of a BALB/c Mouse Model for Allergic Asthma
Q44547056Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences
Q45001530T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice
Q43059347TGF-beta1 causes airway fibrosis and increased collagen I and III mRNA in mice
Q37056577Targeting eosinophils in asthma
Q40086497The Effect of Zataria multiflora on Th1/Th2 and Th17/T Regulatory in a Mouse Model of Allergic Asthma.
Q24550856The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation
Q34620166The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease
Q43689845The effect of rupatadine on lung histopathology in a murine model of chronic asthma.
Q83150383The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice
Q51701514The involvement of matrix metalloproteinases in basement membrane injury in a murine model of acute allergic airway inflammation.
Q24799142The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose
Q50510777The role of bone marrow-derived adult stem cells in a transgenic mouse model of allergic asthma.
Q37358582Therapeutic effects of histone deacetylase inhibitors in a murine asthma model
Q37220309Time sequence of airway remodeling in a mouse model of chronic asthma: the relation with airway hyperresponsiveness
Q51636510Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice.
Q34453206Understanding airway wall remodeling in asthma: a basis for improvements in therapy?
Q33701214Understanding asthma using animal models
Q34349777Understanding the pathogenesis of allergic asthma using mouse models
Q41560889Vascular endothelial growth factor antagonism restores epithelial barrier dysfunction via affecting zonula occludens proteins.
Q24791345What have transgenic and knockout animals taught us about respiratory disease?
Q84290562[Again an asthma model... but a useful one]
Q51075244[Effect of montelukast sodium intervention on airway remodeling and percentage of Th17 cells/CD4+CD25+ regulatory T cells in asthmatic mice].
Q50946913[HMGB1/TLR4/NF-κB signaling pathway and role of vitamin D in asthmatic mice].
Q81520330[Use of the mouse to unravel allergic asthma: a review of the pathogenesis of allergic asthma in mouse models and its similarity to the condition in humans]

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