Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice

scientific article published on January 1997

Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID174566
P698PubMed publication ID8975902

P50authorGilla KaplanQ60908373
P2093author name stringW Ye
J Wang
A L Moreira
K B Elkon
C C Liu
V H Freedman
P Laochumroonvorapong
P2860cites workPurification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactionsQ24675072
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicityQ24680778
The Fas death factorQ29620461
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicityQ34057782
Immune function in mice lacking the perforin geneQ35882128
Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.Q36356796
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infectionQ37347705
Purification and characterization of the Fas-ligand that induces apoptosisQ38310834
CD4+ cytolytic T cells can destroy autologous and MHC-matched macrophages but fail to kill intracellular Mycobacterium bovis-BCG.Q39358590
H2O2 induces monocyte apoptosis and reduces viability of Mycobacterium avium-M. intracellulare within cultured human monocytesQ39824126
Perforin: structure and functionQ40515629
T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigensQ41141434
Recognition and destruction of Bacillus Calmette-Guerin-infected human monocytesQ42941770
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic virusesQ44152234
CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.Q52055815
The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis.Q52135468
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathwaysQ59050520
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme AQ67573762
Lysis of human macrophages by cytolytic CD4+ T cells fails to affect survival of intracellular Mycobacterium bovis-bacille Calmette-Guérin (BCG)Q72388708
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
P304page(s)127-132
P577publication date1997-01-01
P1433published inInfection and ImmunityQ6029193
P1476titlePerforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice
P478volume65

Reverse relations

cites work (P2860)
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Q36400834Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.
Q39473506Characterization of human Mycobacterium bovis bacille Calmette-Guérin-reactive CD8+ T cells.
Q34000680Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis.
Q77419307Co-immunization with DNA vaccines expressing granulocyte-macrophage colony-stimulating factor and mycobacterial secreted proteins enhances T-cell immunity, but not protective efficacy against Mycobacterium tuberculosis
Q36399636Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection
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