Novel PDE4 inhibitors derived from Chinese medicine forsythia

scientific article published on 30 December 2014

Novel PDE4 inhibitors derived from Chinese medicine forsythia is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9k5937C
P356DOI10.1371/JOURNAL.PONE.0115937
P932PMC publication ID4280171
P698PubMed publication ID25549252
P5875ResearchGate publication ID270290732

P50authorTravis LearQ55187835
George D LeikaufQ45733221
P2093author name stringAlison C McKelvey
Bill B Chen
Tiffany A Coon
Rahel L Birru
Nate M Weathington
P2860cites workLung pathology of fatal severe acute respiratory syndrome.Q51670647
Dual expression and differential regulation of phosphodiesterase 3A and phosphodiesterase 3B in human vascular smooth muscle: implications for phosphodiesterase 3 inhibition in human cardiovascular tissuesQ74045579
Absorption and metabolism of cyanidin 3-O-beta-D-glucoside in ratsQ77780939
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation systemQ24304493
Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibitionQ24648587
Structure of the catalytic domain of human phosphodiesterase 5 with bound drug moleculesQ27641962
Cyclic nucleotide phosphodiesterasesQ28203598
Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug developmentQ28242460
Preparing for the next pandemicQ28248583
Viral pneumoniaQ28307886
Targeting F box protein Fbxo3 to control cytokine-driven inflammationQ28392009
Innate immune response of human alveolar macrophages during influenza A infectionQ28731580
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoformsQ29619683
Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophagesQ33564601
Antiplatelet therapy using cilostazol, a specific PDE3 inhibitorQ33800110
Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and miceQ34006798
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationshipsQ34357867
Discovery of novel PDE10 inhibitors by a robust homogeneous screening assayQ34679687
Historical insights into cytokinesQ34708047
Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.Q35047671
The influence of infection sites on development and mortality of ARDS.Q35050455
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathwayQ36080545
ZINCPharmer: pharmacophore search of the ZINC databaseQ36088378
Roflumilast: a selective phosphodiesterase 4 inhibitorQ36358921
Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasisQ36757668
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammationQ36781352
The future of the oral pharmacotherapy of male erectile dysfunction: things to comeQ36866594
Cyclic AMP: master regulator of innate immune cell function.Q37103511
Phosphodiesterase 5 inhibition in essential hypertensionQ37119354
Phosphodiesterase-4 inhibitor therapy for lung diseasesQ38105165
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.Q40204025
Cyclic nucleotide research -- still expanding after half a centuryQ44123887
Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor VardenafilQ45111162
Comparative relaxing effects of sildenafil, vardenafil, and tadalafil in human corpus cavernosum: contribution of endogenous nitric oxide release.Q45178889
Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats.Q46197858
Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative StressQ46329016
Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes.Q46535464
Preparative isolation and purification of phillyrin from the medicinal plant Forsythia suspensa by high-speed counter-current chromatographyQ46633155
Lignans from the fruits of Forsythia suspensaQ46737196
Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensaQ46780457
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)e115937
P577publication date2014-12-30
P1433published inPLOS OneQ564954
P1476titleNovel PDE4 inhibitors derived from Chinese medicine forsythia
P478volume9

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cites work (P2860)
Q50599475Effects of meglumine cyclic adenylate pretreatment on systemic inflammatory response syndrome induced by lipopolysaccharide in rats.
Q47569732Forsythiae Fructus: A Review on its Phytochemistry, Quality Control, Pharmacology and Pharmacokinetics
Q99200887Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway

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