Removal of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3.

scientific article published on February 2004

Removal of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.78.3.1525-1539.2004
P932PMC publication ID321372
P698PubMed publication ID14722307

P2093author name stringJonathan D Steckbeck
Ronald C Desrosiers
Ronald C Montelaro
Kelly Stefano Cole
Jennifer L Rowles
P2860cites workEffects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transportQ24633832
Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 bindingQ24644617
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CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralizationQ28646881
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Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuationQ33814150
N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropismQ33842455
Equine infectious anemia virus envelope evolution in vivo during persistent infection progressively increases resistance to in vitro serum antibody neutralization as a dominant phenotype.Q34349343
Role of N-linked glycans in a human immunodeficiency virus envelope glycoprotein: effects on protein function and the neutralizing antibody responseQ34998032
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoproteinQ36549382
Effects of natural sequence variation on recognition by monoclonal antibodies neutralize simian immunodeficiency virus infectivity.Q36634778
Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees.Q36812220
Sialic acids on the surface of caprine arthritis-encephalitis virus define the biological properties of the virusQ36868748
Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodiesQ36884458
Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteinsQ38334915
Rapid selection for an N-linked oligosaccharide by monoclonal antibodies directed against the V3 loop of human immunodeficiency virus type 1.Q38359755
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Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virusQ38948757
CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicityQ39370718
Production and characterization of SIV envelope-specific rhesus monoclonal antibodies from a macaque asymptomatically infected with a live SIV vaccineQ39402713
Identification of replication-competent strains of simian immunodeficiency virus lacking multiple attachment sites for N-linked carbohydrates in variable regions 1 and 2 of the surface envelope protein.Q39581340
Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope proteinQ39592994
Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/V2 variable loopsQ39602333
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.Q39605077
A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelopeQ39682625
Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunityQ39880154
Characterization of neutralization epitopes of simian immunodeficiency virus (SIV) recognized by rhesus monoclonal antibodies derived from monkeys infected with an attenuated SIV strainQ40746322
Protection of neutralization epitopes in the V3 loop of oligomeric human immunodeficiency virus type 1 glycoprotein 120 by N-linked oligosaccharides in the V1 region.Q40788362
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.Q41151327
Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell linesQ41157521
Control of expression, glycosylation, and secretion of HIV-1 gp120 by homologous and heterologous signal sequencesQ41436920
Identification of an N-linked glycan in the V1-loop of HIV-1 gp120 influencing neutralization by anti-V3 antibodies and soluble CD4.Q41504258
Complementation of human immunodeficiency virus glycoprotein mutations in transQ41609412
Carbohydrate determinant NeuAc-Galbeta(1-4) of N-linked glycans modulates the antigenic activity of human immunodeficiency virus type 1 glycoprotein gp120Q43446688
An N-glycan within the human immunodeficiency virus type 1 gp120 V3 loop affects virus neutralizationQ43451743
Detailed analysis of CD4+ Th responses to envelope and Gag proteins of simian immunodeficiency virus reveals an exclusion of broadly reactive Th epitopes from the glycosylated regions of envelopeQ45733017
V3-specific polyclonal antibodies affinity purified from sera of infected humans effectively neutralize primary isolates of human immunodeficiency virus type 1.Q45734123
Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infectionQ45756087
Properties of virus-like particles produced by SIV-chronically infected human cell clonesQ45771901
A role for carbohydrates in immune evasion in AIDS.Q47982875
N-Linked Glycosylation of the HIV Type-1 gp120 Envelope Glycoprotein as a Major Determinant of CCR5 and CXCR4 Coreceptor UtilizationQ56935643
Hypothetical assignment of intrachain disulfide bonds for HIV-2 and SIV envelope glycoproteinsQ68029498
Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individualQ73149263
Maturation of envelope-specific antibody responses to linear determinants in monkeys inoculated with attenuated SIVQ73208196
A model for the maturation of protective antibody responses to SIV envelope proteins in experimentally immunized monkeysQ73626426
Maturation of immune responses to lentivirus infection: implications for AIDS vaccine developmentQ77550865
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
Simian immunodeficiency virusQ1890246
P304page(s)1525-1539
P577publication date2004-02-01
P1433published inJournal of VirologyQ1251128
P1476titleRemoval of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3.
P478volume78

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cites work (P2860)
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