Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

scientific article published on 23 September 2011

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2011-02-337097
P932PMC publication ID3217366
P698PubMed publication ID21948174
P5875ResearchGate publication ID51675232

P2093author name stringClaudio Anasetti
Joseph Pidala
Anandharaman Veerapathran
Xue-Zhong Yu
Francisca Beato
P2860cites workHuman T regulatory cell therapy: take a billion or so and call me in the morningQ24656069
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycinQ28475626
IDO expression by dendritic cells: tolerance and tryptophan catabolismQ29614752
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
Lymphocyte homing and homeostasisQ29619924
Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemiaQ33629928
Specificity of CD4+CD25+ regulatory T cell function in alloimmunityQ33736744
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantationQ34162461
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaQ34517421
Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.Q34518941
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host diseaseQ34525987
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsQ36228688
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockadeQ36369151
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantationQ36370863
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cellsQ36371345
Clinical application of expanded CD4+25+ cellsQ36386636
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potentialQ36386898
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.Q36399104
Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.Q36641930
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cellsQ36882243
CD28 costimulation is essential for human T regulatory expansion and functionQ36916914
Expansion of human regulatory T-cells from patients with type 1 diabetesQ37105331
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cellsQ37180691
Regulatory T cells after organ transplantation: where does their action take place?Q37220729
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor functionQ40514795
Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.Q40565739
Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human bloodQ41973912
Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral bloodQ41988688
Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host diseaseQ42000621
Efficient and selective prevention of GVHD by antigen-specific induced Tregs via linked-suppression in miceQ42109680
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assaysQ43536416
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic miceQ46081630
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.Q50796687
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.Q51980108
CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells.Q51991426
IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression.Q52003802
Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation.Q53663389
Expansion of CD4+ CD25+ Foxp3+ T cells by bone marrow-derived dendritic cellsQ60321275
IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In VivoQ60700622
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethalityQ78033315
Ex vivo depletion of alloreactive cells based on CFSE dye dilution, activation antigen selection, and dendritic cell stimulationQ79116877
Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation toleranceQ79468642
CD4 CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndromeQ81679698
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)5671-5680
P577publication date2011-09-23
P1433published inBloodQ885070
P1476titleEx vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
P478volume118

Reverse relations

cites work (P2860)
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