Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis.

scientific article published on May 2015

Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis. is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1025147Y
P356DOI10.1371/JOURNAL.PONE.0125147
P932PMC publication ID4416729
P698PubMed publication ID25933213
P5875ResearchGate publication ID275769050

P50authorYusuke FunaiQ84436090
P2093author name stringTakashi Mori
Kiyonobu Nishikawa
Hiroyuki Yamasaki
Tomoharu Funao
P2860cites workInhibitory effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing alpha 7 receptorsQ24673097
Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitroQ24680063
Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesicQ28343021
Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the ratQ28571695
The effects of tramadol and its metabolite on glycine, gamma-aminobutyric acidA, and N-methyl-D-aspartate receptors expressed in Xenopus oocytesQ34413093
Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanismsQ34544649
Receptor binding, analgesic and antitussive potency of tramadol and other selected opioidsQ34556659
Tramadol--the impact of its pharmacokinetic and pharmacodynamic properties on the clinical management of painQ35598082
Sensory processing and functional reorganization of sensory transmission under pathological conditions in the spinal dorsal hornQ35710714
Serum concentrations of tramadol enantiomers during patient-controlled analgesiaQ36053584
Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cordQ36503127
Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodyniaQ39334871
The substantia gelatinosa of the spinal cord: a critical reviewQ40365513
Slow synaptic transmission in the spinal dorsal hornQ41330995
Altered antinociceptive efficacy of tramadol over time in rats with painful peripheral neuropathyQ41408027
Tramadol, but not its major metabolite (mono-O-demethyl tramadol) depresses compound action potentials in frog sciatic nervesQ41594156
Effect of acute and chronic tramadol on [3H]-5-HT uptake in rat cortical synaptosomesQ43176908
Tramadol produces outward currents by activating mu-opioid receptors in adult rat substantia gelatinosa neuronesQ43261444
Mu opioid receptor-dependent and independent components in effects of tramadolQ44331046
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The activation of 5-HT(3) receptors evokes GABA release in the spinal cordQ44497343
Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording.Q44691681
Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn.Q44902325
Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats.Q46935397
In vivo patch-clamp analysis of IPSCs evoked in rat substantia gelatinosa neurons by cutaneous mechanical stimulationQ73054571
Responsiveness of rat substantia gelatinosa neurones to mechanical but not thermal stimuli revealed by in vivo patch-clamp recordingQ73226563
Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 2): effects on somatodendritic sites of GABAergic neuronsQ73484786
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cordQ78040223
Route-dependent stereoselective pharmacokinetics of tramadol and its active O-demethylated metabolite in ratsQ79456732
Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative painQ84105289
The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgiaQ87074767
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e0125147
P577publication date2015-05-01
P1433published inPLOS OneQ564954
P1476titleEffects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis
P478volume10