Role of caveolin and caveolae in insulin signaling and diabetes

scientific article published on December 1, 2003

Role of caveolin and caveolae in insulin signaling and diabetes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00324.2003
P953full work available at URLhttp://intl-ajpendo.physiology.org/cgi/content/abstract/285/6/E1151
https://www.physiology.org/doi/pdf/10.1152/ajpendo.00324.2003
P698PubMed publication ID14607781
P5875ResearchGate publication ID9017115

P50authorPhilipp E. SchererQ60572448
Michael P. LisantiQ77913186
P2093author name stringTerry P. Combs
Alex W. Cohen
P2860cites workCAP defines a second signalling pathway required for insulin-stimulated glucose transportQ24290287
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassetteQ24290507
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10Q24291135
Insulin signalling and the regulation of glucose and lipid metabolismQ24292020
Identification, sequence, and expression of caveolin-2 defines a caveolin gene familyQ24315913
Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteinsQ24322008
Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivoQ24324547
Mechanisms of nutritional and hormonal regulation of lipogenesisQ24522517
Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathwayQ28189761
Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted systemQ28212772
Regulated transport of the glucose transporter GLUT4Q28216848
Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activitiesQ28255025
Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscleQ28273695
Caveolin is an activator of insulin receptor signalingQ28284137
Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteinsQ28304307
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J miceQ28369792
Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localizationQ28507990
Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3Q28578902
Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signalingQ28581283
Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted miceQ29615180
Activation of glycogen synthase by insulin in 3T3-L1 adipocytes involves c-Cbl-associating protein (CAP)-dependent and CAP-independent signaling pathways.Q30168433
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocationQ30441963
Isolation and lipid characterization of cholesterol-enriched fractions in cortical and nuclear human lens fibersQ31136232
Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase controlQ31716904
On the control of lipolysis in adipocytesQ33936993
Lipid rafts are required for GLUT4 internalization in adipose cellsQ33946982
Caveolins in cholesterol trafficking and signal transduction: implications for human disease.Q34095985
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intoleranceQ34137882
Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathwaysQ34159434
Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.Q34451462
Caveolin-deficient mice: insights into caveolar function human diseaseQ34457018
Insulin signaling pathways in time and space.Q34534983
The fine structure of the gall bladder epithelium of the mouse.Q34537858
Mouse models of insulin resistanceQ34588917
IRS proteins and the common path to diabetesQ34778267
Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptorQ34994283
SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis.Q35888471
Cholesterol depletion blocks redistribution of lipid raft components and insulin-mimetic signaling by glimepiride and phosphoinositolglycans in rat adipocytesQ36087982
Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesiclesQ36234898
Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4.Q36235656
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activationQ36323578
A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistanceQ38319653
Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptorQ38362717
Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytesQ39459824
Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I.Q40702179
Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolaeQ40736924
Mutational analysis identifies a short atypical membrane attachment sequence (KYWFYR) within caveolin-1.Q40745371
Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteinsQ40814974
A molecular dissection of caveolin-1 membrane attachment and oligomerization. Two separate regions of the caveolin-1 C-terminal domain mediate membrane binding and oligomer/oligomer interactions in vivoQ40881286
Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactionsQ41127799
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membraneQ41715384
Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetesQ41809606
Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytesQ41861046
Insulin stimulates the tyrosine phosphorylation of caveolinQ41881930
The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4.Q42434971
Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cellsQ42442501
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytesQ42483514
Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissueQ42803748
p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activityQ42809229
The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranesQ42809492
The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1.Q42814621
Caveolin-1 expression enhances endothelial capillary tubule formationQ42822849
Insulin induces translocation of glucose transporter GLUT4 to plasma membrane caveolae in adipocytes.Q42822979
Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYQ43672984
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalitiesQ43678714
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation during the lactation cycle of the rat.Q43792591
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalitiesQ43819817
Glutamate regulates caveolin expression in rat hippocampal neuronsQ44387884
Cellular apoptosis is associated with increased caveolin-1 expression in macrophagesQ44460196
Crowded little caves: structure and function of caveolaeQ47329891
Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domainQ47881243
Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols.Q51840956
Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.Q54136053
Insulin and alpha 2-macroglobulin-methylamine undergo endocytosis by different mechanisms in rat adipocytes: II. Comparison of intracellular eventsQ68204681
Insulin and alpha 2-macroglobulin-methylamine undergo endocytosis by different mechanisms in rat adipocytes: I. Comparison of cell surface eventsQ69010358
Translocation of perilipin and hormone-sensitive lipase in response to lipolytic hormonesQ74119305
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose toleranceQ77652485
A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitroQ78069859
Effects of deleting a tripeptide sequence observed in muscular dystrophy patients on the conformation of synthetic peptides corresponding to the scaffolding domain of caveolin-3Q78395500
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectsignal transductionQ828130
physiologyQ521
preproinsulinQ7240673
P304page(s)E1151-60
P577publication date2003-12-01
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleRole of caveolin and caveolae in insulin signaling and diabetes
P478volume285

Reverse relations

cites work (P2860)
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