Frequent MED12 mutations in phyllodes tumours of the breast

scientific article published on 2 April 2015

Frequent MED12 mutations in phyllodes tumours of the breast is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1025502654
P356DOI10.1038/BJC.2015.116
P932PMC publication ID4430713
P698PubMed publication ID25839987

P2093author name stringH Yoshida
M Yoshida
S Sekine
T Kinoshita
Y Kanai
A Ochiai
R Ogawa
A Maeshima
P2860cites workA comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence.Q50645407
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors.Q50990283
Phyllodes tumors of the breast segregate in two groups according to genetic criteria.Q53567961
Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death.Q54690940
The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumoursQ64019020
Prevalence of benign, atypical, and malignant breast lesions in populations at different risk for breast cancer. A forensic autopsy studyQ69442439
The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 casesQ71018151
Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysisQ71067024
Non-operative management of breast masses diagnosed as fibroadenomaQ71938390
Long-term risk of breast cancer in women with fibroadenomaQ72508883
Recurrent and metastatic cystosarcoma phyllodesQ72948474
Primary treatment of cystosarcoma phyllodes of the breastQ73025445
Increased p53 protein expression in malignant mammary phyllodes tumorsQ74462561
Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assayQ74717587
Indicence of chronic cystic disease in so-called "normal breasts; a study based on 225 postmortem examinationsQ75795826
p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray studyQ81419884
Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progressionQ81419915
Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.Q37074113
Recurrent challenges in the evaluation of fibroepithelial lesionsQ37470496
A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathwayQ37721452
Rb loss is characteristic of prostatic small cell neuroendocrine carcinomaQ39044979
Epithelial--stromal interactions in tumors. A morphologic study of fibroepithelial tumors of the breastQ41085895
Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumoursQ46921387
Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomasQ28243075
Evidence for transformation of fibroadenoma of the breast to malignant phyllodes tumorQ33416718
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.Q33698048
Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomasQ34200667
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomasQ34210977
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.Q34429754
Fibroepithelial tumors of the breast: pathologic and immunohistochemical features and molecular mechanismsQ35078803
Interobserver variability by pathologists in the distinction between cellular fibroadenomas and phyllodes tumorsQ35155631
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumorsQ35681234
Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal componentsQ35809903
Frequency of benign and malignant breast lesions in 207 consecutive autopsies in Australian womenQ35992095
Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsiesQ36029584
Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 casesQ36239207
Histological features useful in the distinction of phyllodes tumour and fibroadenoma on needle core biopsy of the breastQ36922437
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 InternationalQ42553662
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1703-1708
P577publication date2015-04-02
P1433published inBritish Journal of CancerQ326309
P1476titleFrequent MED12 mutations in phyllodes tumours of the breast
P478volume112

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cites work (P2860)
Q36907393Characterization of a murine xenograft model for contrast agent development in breast lesion malignancy assessment
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Q100526089Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations
Q26785389Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer
Q60956561Factors targeting to drive tumorigenesis?
Q95933719Fibroepithelial lesions revisited: implications for diagnosis and management
Q53267835Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.
Q41195725Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast
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Q46053202Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.
Q37581351Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.
Q96955010Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences
Q53179448MED12 exon 2 mutation as a highly sensitive and specific marker in distinguishing phyllodes tumours from other spindle neoplasms of the breast.
Q41712515MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases
Q52876304MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.
Q50120771MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours
Q33915051Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor
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Q26800203Mediator kinase module and human tumorigenesis
Q93163764Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study
Q35669552Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing
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Q42376001Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways
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Q92286502Reasons to Reconsider Risk Associated With Power Morcellation of Uterine Fibroids
Q93358771Recurrent MED12 exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults
Q47176937Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast
Q36287405TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast
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Q39580452Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway
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Q90446566Utility of Trucut Biopsy in Diagnosing Phyllodes Tumor