Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis

scientific article published on 10 April 2015

Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1050852076
P356DOI10.1186/S12864-015-1407-6
P932PMC publication ID4438569
P698PubMed publication ID25885771
P5875ResearchGate publication ID275048896

P50authorArnfinn SundsfjordQ53678285
Kristin HegstadQ57305211
Rob J. L. WillemsQ57907689
Ewa SadowyQ59144549
Lars B JensenQ42644355
Willem van SchaikQ42273114
P2093author name stringGuido Werner
Teresa M Coque
Theresa Mikalsen
Torunn Pedersen
P2860cites workRole of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalisQ22065825
Toxin-antitoxin systems: Biology, identification, and applicationQ26866487
Genomic and SNP analyses demonstrate a distant separation of the hospital and community-associated clades of Enterococcus faeciumQ28732418
Global spread of the hyl(Efm) colonization-virulence gene in megaplasmids of the Enterococcus faecium CC17 polyclonal subclusterQ30387999
Microevolutionary events involving narrow host plasmids influences local fixation of vancomycin-resistance in Enterococcus populationsQ31114643
Insertion sequence-driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faeciumQ33270515
Genetic diversity among Enterococcus faecalisQ33289954
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity islandQ33557553
Comparative genomics and transduction potential of Enterococcus faecalis temperate bacteriophagesQ33616966
DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates.Q33690791
Characterization of the pheromone response of the Enterococcus faecalis conjugative plasmid pCF10: complete sequence and comparative analysis of the transcriptional and phenotypic responses of pCF10-containing cells to pheromone inductionQ33758514
Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalisQ33785415
Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinantsQ33785512
IS element IS16 as a molecular screening tool to identify hospital-associated strains of Enterococcus faeciumQ33858793
Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animalsQ33976380
Co-transfer of resistance to high concentrations of copper and first-line antibiotics among Enterococcus from different origins (humans, animals, the environment and foods) and clonal lineagesQ46958806
Abundance and diversity of plasmid-associated genes among clinical isolates of Enterococcus faecalisQ47882150
Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureusQ47974985
High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland.Q48040002
A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolatesQ48062305
Tn1546 structures and multilocus sequence typing of vanA-containing enterococci of animal, human and food originQ48064592
Insertion sequence ISEcp1-like element connected with a novel aph(2'') allele [aph(2'')-Ie] conferring high-level gentamicin resistance and a novel streptomycin adenylyltransferase gene in EnterococcusQ48084191
Presence of erm gene classes in gram-positive bacteria of animal and human origin in Denmark.Q50562607
Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark.Q50567089
CRISPR-Cas, a prokaryotic adaptive immune system, in endodontic, oral, and multidrug-resistant hospital-acquired Enterococcus faecalis.Q52422668
Genetic linkage of the vanB2 gene cluster to Tn5382 in vancomycin-resistant enterococci and characterization of two novel insertion sequences.Q54048951
Identification of regions of the Streptococcus faecalis plasmid pCF-10 that encode antibiotic resistance and pheromone response functions.Q54429232
Multiple-antibiotic resistance of Enterococcus faecalis and Enterococcus faecium from cecal contents in broiler chicken and turkey flocks slaughtered in Canada and plasmid colocalization of tetO and ermB genes.Q55055044
A classification system for plasmids from enterococci and other Gram-positive bacteriaQ59231961
Bacteriophage-mediated transduction of antibiotic resistance in enterococciQ60229439
Conjugal transfer of the vancomycin resistance determinant vanB between enterococci involves the movement of large genetic elements from chromosome to chromosomeQ72107330
Do biocides select for antibiotic resistance?Q73543484
Insight into antimicrobial susceptibility and population structure of contemporary human Enterococcus faecalis isolates from EuropeQ83154580
Clustering of polyclonal VanB-type vancomycin-resistant Enterococcus faecium in a low-endemic area was associated with CC17-genogroup strains harbouring transferable vanB2-Tn5382 and pRUM-like repA containing plasmids with axe-txe plasmid addictionQ83861669
Presence of pRI1: a small cryptic mobilizable plasmid isolated from Enterococcus faecium of human and animal originQ42599156
Cloning of insertion sequence IS1485 from Enterococcus speciesQ42606085
Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.Q42627595
Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281.Q42631496
pS86, a new theta-replicating plasmid from Enterococcus faecalis.Q42633337
A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faeciumQ42633957
Molecular analysis of the replication region of the pCIZ2 plasmid from the multiple bacteriocin producer strain Enterococcus faecium L50.Q42664729
Nucleotide sequence of the Staphylococcus aureus transposon, Tn5405, carrying aminoglycosides resistance genesQ42667881
Identification of a novel insertion sequence in vanB2-containing Enterococcus faeciumQ42694612
Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faeciumQ42695363
Nucleotide sequence of IS1678, an insertion sequence in the vanA cluster of enterococciQ42708844
Prevalence of the vanB2 gene cluster in vanB glycopeptide-resistant enterococci in the United Kingdom and the Republic of Ireland and its association with a Tn5382-like elementQ42730233
Typing of vancomycin-resistant enterococci obtained from patients at Danish hospitals and detection of a genomic island specific to CC17 Enterococcus faeciumQ43203464
PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systemsQ43218655
High-level ciprofloxacin resistance among hospital-adapted Enterococcus faecium (CC17).Q43223789
Genome-based insights into the evolution of enterococciQ43456168
Updating benchtop sequencing performance comparisonQ43497116
Distribution of the antiseptic resistance genes qacA, qacB and qacC in 497 methicillin-resistant and -susceptible European isolates of Staphylococcus aureusQ43627876
Complete sequence of Enterococcus faecium pVEF3 and the detection of an omega-epsilon-zeta toxin-antitoxin module and an ABC transporterQ43734155
A new Tn1546 type of VanB phenotype-vanA genotype vancomycin-resistant Enterococcus faecium isolates in mainland ChinaQ44245876
Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages.Q44426084
High prevalence of ST-78 infection-associated vancomycin-resistant Enterococcus faecium from hospitals in Asunción, Paraguay.Q44592839
Linkage of erm(B) and aadE-sat4-aphA-3 in multiple-resistant Enterococcus faecium isolates of different ecological originsQ44665881
Identification of an unusual VanA element in glycopeptide-resistant Enterococcus faecium in Brazil following international transfer of a bone marrow transplant patient.Q45220337
Clonal expansion within clonal complex 2 and spread of vancomycin-resistant plasmids among different genetic lineages of Enterococcus faecalis from PortugalQ46070406
Occurrence of insertion sequences within the genomes and Tn1546-like elements of glycopeptide-resistant enterococci isolated in Brazil, and identification of a novel element, ISEfa5.Q46403838
Molecular analysis of the gene cluster involved in the production and secretion of enterocins 1071A and 1071B and of the genes responsible for the replication and transfer of plasmid pEF1071.Q46535868
Macrolide resistance genes in Enterococcus sppQ33979149
Effects of the movement of insertion sequences on the structure of VanA glycopeptide resistance elements in Enterococcus faeciumQ33979539
Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traitsQ33981865
Occurrence of mazEF-like antitoxin/toxin systems in bacteriaQ34004308
A multicentre hospital outbreak in Sweden caused by introduction of a vanB2 transposon into a stably maintained pRUM-plasmid in an Enterococcus faecium ST192 cloneQ34083350
Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalisQ34123227
GABenchToB: a genome assembly benchmark tuned on bacteria and benchtop sequencersQ34149898
Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureusQ34151028
Horizontal gene transfer and the genomics of enterococcal antibiotic resistanceQ34203823
ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic developmentQ34206489
Multidrug-resistant enterococci lack CRISPR-casQ34285916
The toxin-antitoxin system of the streptococcal plasmid pSM19035.Q34444220
Bac 32, a novel bacteriocin widely disseminated among clinical isolates of Enterococcus faeciumQ34510479
Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmidsQ34741076
ccrABEnt serine recombinase genes are widely distributed in the Enterococcus faecium and Enterococcus casseliflavus species groups and are expressed in E. faeciumQ34747082
Enterococcus faecalis prophage dynamics and contributions to pathogenic traitsQ34765413
Molecular analysis of streptogramin resistance in enterococciQ34796546
Txe, an endoribonuclease of the enterococcal Axe–Txe toxin–antitoxin system, cleaves mRNA and inhibits protein synthesisQ34954571
Defining the mobilomeQ34959127
VanD-type vancomycin-resistant Enterococcus faecium 10/96A.Q35033455
Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken fecesQ35091769
Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United StatesQ35111529
Genetic analysis of bacteriocin 43 of vancomycin-resistant Enterococcus faeciumQ35130004
Identification and characterization of IS1476, an insertion sequence-like element that disrupts VanY function in a vancomycin-resistant Enterococcus faecium strainQ35137804
Characterization and sequence analysis of a stable cryptic plasmid from Enterococcus faecium 226 and development of a stable cloning vector.Q35190169
Selection of fecal enterococci exhibiting tcrB-mediated copper resistance in pigs fed diets supplemented with copper.Q35191282
Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40.Q35218419
In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalisQ35350299
Molecular structure and evolution of the conjugative multiresistance plasmid pRE25 of Enterococcus faecalis isolated from a raw-fermented sausageQ35575244
Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococciQ35576011
Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistanceQ35622545
Effects of tylosin use on erythromycin resistance in enterococci isolated from swineQ35662736
Clonal structure of Enterococcus faecalis isolated from Polish hospitals: characterization of epidemic clonesQ35690249
Local genetic patterns within a vancomycin-resistant Enterococcus faecalis clone isolated in three hospitals in PortugalQ39954529
Characterization of the gentamicin resistance transposon Tn5281 from Enterococcus faecalis and comparison to staphylococcal transposons Tn4001 and Tn4031Q40284287
Identification and characterization of a family of toxin-antitoxin systems related to the Enterococcus faecalis plasmid pAD1 par addiction moduleQ40323160
Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombinationQ41483697
Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in NorwayQ41828043
Nonclinical and clinical Enterococcus faecium strains, but not Enterococcus faecalis strains, have distinct structural and functional genomic featuresQ41907917
Molecular analysis of human, porcine, and poultry Enterococcus faecium isolates and their erm(B) genesQ42000987
Diversity of Tn1546 in vanA-positive Enterococcus faecium clinical isolates with VanA, VanB, and VanD phenotypes and susceptibility to vancomycinQ42255534
Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatmentQ42273050
The recombinase IntA is required for excision of esp-containing ICEEfm1 in Enterococcus faecium.Q42582856
GAGE: A critical evaluation of genome assemblies and assembly algorithmsQ35791586
Comparative analysis of the first complete Enterococcus faecium genomeQ35942806
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.Q35965824
Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complexQ36009410
Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavusQ36029203
Identification, characterization, and nucleotide sequence of a region of Enterococcus faecalis pheromone-responsive plasmid pAD1 capable of autonomous replicationQ36093488
Restricted gene flow among hospital subpopulations of Enterococcus faecium.Q36145891
Streptococcus faecalis sex pheromone (cAM373) also produced by Staphylococcus aureus and identification of a conjugative transposon (Tn918).Q36305871
Emergence of CC17 Enterococcus faecium: from commensal to hospital-adapted pathogen.Q37086110
Development of a standardized screening method for detection of vancomycin-resistant enterococciQ37088075
Emergence of epidemic multidrug-resistant Enterococcus faecium from animal and commensal strainsQ37105688
The RepA_N replicons of Gram-positive bacteria: a family of broadly distributed but narrow host range plasmidsQ37120439
Dispersion of multidrug-resistant Enterococcus faecium isolates belonging to major clonal complexes in different Portuguese settingsQ37256153
Control of gene expression by CRISPR-Cas systemsQ37277585
A modular master on the move: the Tn916 family of mobile genetic elements.Q37493047
Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombsQ37576199
The role of CRISPR-Cas systems in virulence of pathogenic bacteriaQ37643438
Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA geneQ37713762
Does the wide use of quaternary ammonium compounds enhance the selection and spread of antimicrobial resistance and thus threaten our health?Q37724848
Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium.Q37766919
Toxins-antitoxins: diversity, evolution and functionQ37912155
Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fateQ38071667
Antibiotic resistant enterococci-tales of a drug resistance gene traffickerQ38100456
The cell wall architecture of Enterococcus faecium: from resistance to pathogenesis.Q38125495
Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systemsQ38187662
Typeability of Tn1546-like elements in vancomycin-resistant enterococci using long-range PCRs and specific analysis of polymorphic regionsQ38311109
Vancomycin-variable Enterococcus faecium: in vivo emergence of vancomycin resistance in a vancomycin-susceptible isolateQ38857080
Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.Q39458422
Heterogeneity in the vanB gene cluster of genomically diverse clinical strains of vancomycin-resistant enterococciQ39470041
Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faeciumQ39557569
tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistanceQ39651680
Nonconjugative transposition of the vanB-containing Tn5382-like element in Enterococcus faeciumQ39740451
Multiplex PCR for detection of aminoglycoside resistance genes in enterococci.Q39743479
Erythromycin resistance by ribosome modificationQ39779280
Tn5384, a composite enterococcal mobile element conferring resistance to erythromycin and gentamicin whose ends are directly repeated copies of IS256.Q39779734
Physical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone responseQ39838537
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumErratum to: Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalisQ43249922
P407language of work or nameEnglishQ1860
P921main subjectEnterococcus faeciumQ140010
Enterococcus faecalisQ140014
P304page(s)282
P577publication date2015-04-10
P1433published inBMC GenomicsQ15765854
P1476titleInvestigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis
P478volume16

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Q43249922Erratum to: Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalismain subjectP921

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