Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice

scientific article published on 20 November 2011

Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/383608
P8608Fatcat IDrelease_n443fyhx7jfydikjj2yyggwmmy
P932PMC publication ID3235668
P698PubMed publication ID22203870
P5875ResearchGate publication ID51954237

P2093author name stringYi-Ching Li
Chung-Hsin Yeh
Yu-Hsiang Kuan
Ming-Ling Yang
P2860cites workEffect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophilQ43714977
Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in miceQ43919941
Stearic acid attenuates cholestasis-induced liver injuryQ45405765
Erythropoietin attenuates lung injury in lipopolysaccharide treated ratsQ46088642
Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injuryQ46425909
Effects of macrophage inducible nitric oxide synthase in murine septic lung injuryQ46895496
The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cellsQ74055104
Bacterial endotoxin is an active component of cigarette smokeQ74619159
Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome?Q80753044
Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cellsQ23923335
The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcomeQ24802498
NF-kappaB and the immune responseQ28271031
Distribution and biological activities of the flavonoid luteolinQ28306957
Function and activation of NF-kappa B in the immune systemQ29547790
NF-kappaB: a key role in inflammatory diseasesQ29617726
Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injuryQ30437105
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lungQ30439575
Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophilsQ33557487
Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental studyQ33577617
Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitationsQ33900029
Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophageQ33919428
Neutrophils and acute lung injuryQ33965359
Transcriptional mechanisms of acute lung injuryQ34399578
Phosphoinositide 3-kinase signalling--which way to target?Q35181798
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndromeQ35638490
Regulatory effects of iNOS on acute lung inflammatory responses in miceQ35843243
Innate immunity in the lungsQ36328672
The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicineQ37815488
Luteolin Ameliorates Experimental Lung Fibrosis Both in Vivo and in Vitro: Implications for Therapy of Lung FibrosisQ39642363
Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophagesQ40058386
Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lungQ40109343
The pathogenesis of sepsis. Factors that modulate the response to gram-negative bacterial infectionQ40667669
Bacterial-induced release of inflammatory mediators by bronchial epithelial cellsQ41175410
Physiologic, biochemical, and imaging characterization of acute lung injury in miceQ42640154
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectlipopolysaccharideQ421804
acute lung injuryQ4677935
P304page(s)383608
P577publication date2011-11-20
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleLuteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice
P478volume2012

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cites work (P2860)
Q35283203A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB
Q53642816Acute lung injury induced by lipopolysaccharide is inhibited by wogonin in mice via reduction of Akt phosphorylation and RhoA activation.
Q93155975Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals
Q35077810Bisgma stimulates prostaglandin E2 production in macrophages via cyclooxygenase-2, cytosolic phospholipase A2, and mitogen-activated protein kinases family
Q42701108Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α.
Q36916195Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB
Q36162961Gelam Honey Inhibits the Production of Proinflammatory, Mediators NO, PGE(2), TNF-α, and IL-6 in Carrageenan-Induced Acute Paw Edema in Rats.
Q35808131Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF- κ B Signaling.
Q33894122Inhibitory effect of the Pseudobrickellia brasiliensis (Spreng) R.M. King & H. Rob. aqueous extract on human lymphocyte proliferation and IFN-γ and TNF-α production in vitro
Q33917752Luteolin prevents uric acid-induced pancreatic β-cell dysfunction.
Q38070106Molecular mechanism underlying anti-inflammatory and anti-allergic activities of phytochemicals: an update
Q53701902Nobiletin-Ameliorated Lipopolysaccharide-Induced Inflammation in Acute Lung Injury by Suppression of NF-κB Pathway In Vivo and Vitro.
Q51618255Novel 5-Hydroxy, 5-Substituted Benzenesulfonamide Pyrimidine-2,4,6-Triones Attenuate Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of the Gelatinases, MMP-2 and MMP-9.
Q37260532Potential effects of medicinal plants and secondary metabolites on acute lung injury
Q39164977Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells
Q41465226Rabdosia japonica var. glaucocalyx Flavonoids Fraction Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Q40198347Rutin improves endotoxin-induced acute lung injury via inhibition of iNOS and VCAM-1 expression
Q54469621Suppression of MAPK and NF-κB pathways by limonene contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury.
Q51308719The Role of IL-33 on LPS-Induced Acute Lung Injury in Mice.
Q36883254The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury
Q39202269Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells.

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