PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse.

scientific article published on May 2015

PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0004-15.2015
P932PMC publication ID4438124
P698PubMed publication ID25995463

P50authorLarry A GrossQ54109606
John T NgoQ57334943
Sakina F PalidaQ87350813
Margaret T ButkoQ87350815
P2093author name stringMark H Ellisman
Roger Y Tsien
Mason R Mackey
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PKM-ζ is not required for hippocampal synaptic plasticity, learning and memoryQ24598900
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Prkcz null mice show normal learning and memoryQ24632507
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Teaching old NCATs new tricks: using non-canonical amino acid tagging to study neuronal plasticityQ38128449
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Distribution of protein kinase Mzeta and the complete protein kinase C isoform family in rat brainQ74302730
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A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organismsQ27321551
Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memoryQ28186778
Protein kinase Mzeta is necessary and sufficient for LTP maintenanceQ28210214
Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zetaQ28241074
Storage of spatial information by the maintenance mechanism of LTPQ28260037
Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenanceQ28487557
Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational controlQ28570179
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTPQ28703578
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Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterationsQ30491040
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Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storageQ34452179
Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactionsQ34466011
Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent.Q34544318
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)Q34686995
A bright and photostable photoconvertible fluorescent proteinQ34929835
Spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions.Q35156972
Regulation of AMPA receptor function by the human memory-associated gene KIBRA.Q35436239
Dendritic transport and localization of protein kinase Mzeta mRNA: implications for molecular memory consolidationQ35690019
Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memoryQ35921522
Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopyQ36431425
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animalsQ36685836
Regulatory mechanisms of AMPA receptors in synaptic plasticityQ36712947
Posttranslational modifications and receptor-associated proteins in AMPA receptor trafficking and synaptic plasticity.Q36876118
LTP maintenance and its protein synthesis-dependenceQ36998727
Competing molecular interactions of aPKC isoforms regulate neuronal polarityQ37143413
AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.Q37351400
KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ.Q37626499
How does PKMζ maintain long-term memory?Q37814073
P4510describes a project that usesImageJQ1659584
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)7736-7749
P577publication date2015-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titlePKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse
P478volume35

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cites work (P2860)
Q47169535Activity-dependent expression of Channelrhodopsin at neuronal synapses
Q59357737Chemogenetic control of gene expression and cell signaling with antiviral drugs
Q54977873Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking.
Q47136160Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors.
Q38811743Mechanisms of polarity protein expression control.
Q44846478Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species
Q98177386Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice
Q39377253Recent insights on principles of synaptic protein degradation
Q33361879The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle
Q46450835The genetics of PKMζ and memory maintenance.
Q60929013What does LTP tell us about the roles of CaMKII and PKMζ in memory?
Q91743620aPKC in neuronal differentiation, maturation and function
Q41620823eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology.

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