MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease

scientific article published on 20 May 2015

MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2015PLoSO..1026423D
P356DOI10.1371/JOURNAL.PONE.0126423
P932PMC publication ID4439119
P698PubMed publication ID25992776
P5875ResearchGate publication ID277084635

P50authorDirk LassnerQ51846321
Johannes DenkQ59703132
Holger JahnQ43017711
Christine S SiegismundQ45383056
P2093author name stringSönke Arlt
Kai Boelmans
P2860cites workClassification of primary progressive aphasia and its variantsQ24594803
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ24595802
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementiaQ24598142
A novel pathway regulates memory and plasticity via SIRT1 and miR-134Q24624906
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAsQ24635151
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The involvement of microRNAs in neurodegenerative diseasesQ26858788
MicroRNA profiling: approaches and considerationsQ26861675
Methodological challenges in utilizing miRNAs as circulating biomarkersQ27027950
A blood based 12-miRNA signature of Alzheimer disease patientsQ27499741
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Q27860893
Alzheimer's disease: genes, proteins, and therapyQ28131806
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experimentsQ28236560
MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 miceQ28287534
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ29547554
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ29614406
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteriaQ29614408
A brain-specific microRNA regulates dendritic spine developmentQ29614753
Alzheimer's diseaseQ29616743
The MicroRNA Spectrum in 12 Body FluidsQ29618068
Mild cognitive impairment as a diagnostic entityQ29619568
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Q30539812
The German Competence Net Dementias: standard operating procedures for the neurochemical dementia diagnosticsQ33249870
Reproducibility of quantitative RT-PCR array in miRNA expression profiling and comparison with microarray analysisQ33498129
A practical approach to RT-qPCR-Publishing data that conform to the MIQE guidelinesQ33538911
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.Q33722837
Transcriptional landscape of the prenatal human brainQ33926910
CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's diseaseQ34113001
miR-375 inhibits differentiation of neurites by lowering HuD levelsQ34119806
MicroRNA profiling: separating signal from noiseQ34135031
A new way of identifying biomarkers in biomedical basic-research studiesQ34273474
Proposed declassification of disease categories related to sexual orientation in the International Statistical Classification of Diseases and Related Health Problems (ICD-11)Q34399598
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's diseaseQ34635272
Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ34988061
Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkersQ35000824
Extracellular microRNA: a new source of biomarkersQ35417685
Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's diseaseQ35791628
microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)Q36499038
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expressionQ36609033
NF-κB-regulated, proinflammatory miRNAs in Alzheimer's diseaseQ36632979
An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cellsQ36968407
The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies.Q37080125
Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologiesQ37158033
Epigenetics, oxidative stress, and Alzheimer diseaseQ37169854
Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseasesQ37332243
Identification of differentially expressed microRNAs across the developing human brainQ37341793
MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasmaQ37669025
Epigenetic regulation in the pathophysiology of Alzheimer's diseaseQ37680418
Fluid biomarkers for diagnosing dementia: rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia recommendations for Canadian physiciansQ37693146
Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease.Q51889715
MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease.Q53457447
Circulating microRNAs in the cerebrospinal fluid of patients with brain diseases.Q54257764
Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models.Q37739709
Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?Q37778884
Circulating microRNAs: Association with disease and potential use as biomarkersQ37818867
Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization InitiativeQ37952021
MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's diseaseQ37961383
miR-9: a versatile regulator of neurogenesisQ38169147
Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasetsQ38194374
Robust microRNA stability in degraded RNA preparations from human tissue and cell samplesQ39717005
Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathwaysQ39975165
Validation of a multiplex reverse transcription and pre-amplification method using TaqMan(®) MicroRNA assays.Q42148804
A miRNA-tRNA mix-up: tRNA origin of proposed miRNAQ43410236
Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer diseaseQ43883164
MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid.Q44001848
Increased expression of the amyloid precursor beta-secretase in Alzheimer's diseaseQ44060098
Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF.Q48208608
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampusQ48266570
Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) studyQ48296508
Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortexQ48637426
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
Alzheimer's diseaseQ11081
biomarkerQ864574
microRNA profilingQ112543306
P304page(s)e0126423
P577publication date2015-05-20
P1433published inPLOS OneQ564954
P1476titleMicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
P478volume10

Reverse relations

cites work (P2860)
Q92324148A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
Q39143773A Customized Quantitative PCR MicroRNA Panel Provides a Technically Robust Context for Studying Neurodegenerative Disease Biomarkers and Indicates a High Correlation Between Cerebrospinal Fluid and Choroid Plexus MicroRNA Expression.
Q90574790A combined miRNA-piRNA signature to detect Alzheimer's disease
Q38927615A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease
Q39542328Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy
Q64053941Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer's disease
Q38681920Alzheimer's Disease and ncRNAs.
Q92670283An investigation of microRNA-103 and microRNA-107 as potential blood-based biomarkers for disease risk and progression of Alzheimer's disease
Q38887384An overview of circulating cell-free microRNAs as putative biomarkers in Alzheimer's and Parkinson's Diseases
Q38855547Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?
Q48343851Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity
Q38979999Biomarkers for the Early Detection and Progression of Alzheimer's Disease
Q89834995CD38 in Neurodegeneration and Neuroinflammation
Q38599053CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells
Q39293214CSF microRNA Profiling in Alzheimer's Disease: a Screening and Validation Study
Q48140499Can Astrocytes Be a Target for Precision Medicine?
Q90499162Cerebral Amyloid Angiopathy, Alzheimer's Disease and MicroRNA: miRNA as Diagnostic Biomarkers and Potential Therapeutic Targets
Q34524908Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis
Q58300998Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study
Q48066803Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - What do we need to know?
Q90057646Diagnostic and prognostic value of microRNAs for Alzheimer's disease: a comprehensive meta-analysis
Q47562648Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.
Q60300574Epigenetics of chronic inflammatory diseases
Q47123147Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.
Q64066945Extracellular Vesicle as a Source of Alzheimer's Biomarkers: Opportunities and Challenges
Q33871862Extracellular Vesicles as a Source of Urological Biomarkers: Lessons Learned From Advances and Challenges in Clinical Applications to Major Diseases.
Q59510880Extracellular microRNAs as messengers in the central and peripheral nervous system
Q92229339Identification of circulating microRNA signatures as potential biomarkers in the serum of elk infected with chronic wasting disease
Q59531635Identification of miRNAs as Potential Biomarkers in Cerebrospinal Fluid from Amyotrophic Lateral Sclerosis Patients
Q41037766Identification of the Role of miR-142-5p in Alzheimer's Disease by Comparative Bioinformatics and Cellular Analysis
Q42371042Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery
Q60922781MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene
Q47206473MicroRNA Exocytosis by Vesicle Fusion in Neuroendocrine Cells
Q51758072MicroRNA Expression Levels Are Altered in the Cerebrospinal Fluid of Patients with Young-Onset Alzheimer's Disease.
Q38749271MicroRNA Profile in Patients with Alzheimer's Disease: Analysis of miR-9-5p and miR-598 in Raw and Exosome Enriched Cerebrospinal Fluid Samples
Q42293337MicroRNA exocytosis by large dense-core vesicle fusion
Q60305849MicroRNA isolation and quantification in cerebrospinal fluid: A comparative methodical study
Q102213603MicroRNA profiling as a novel diagnostic tool for identification of patients with inflammatory and/or virally induced cardiomyopathies
Q44618765MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy
Q37106716MicroRNA-135b has a neuroprotective role via targeting of β-site APP-cleaving enzyme 1.
Q36934113MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
Q90361808MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma
Q36290224MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies.
Q99711177MicroRNAs in Alzheimer's Disease: Function and Potential Applications as Diagnostic Biomarkers
Q39215093MicroRNAs in Human Cerebrospinal Fluid as Biomarkers for Alzheimer's Disease.
Q38843644MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Q26744819MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases
Q41064717NeurimmiRs and Postoperative Delirium in Elderly Patients Undergoing Total Hip/Knee Replacement: A Pilot Study
Q47880484Noncoding RNAs in neurodegeneration
Q91629118Panoramic Visualization of Circulating MicroRNAs Across Neurodegenerative Diseases in Humans
Q64103320Physical Activity Alleviates Cognitive Dysfunction of Alzheimer's Disease through Regulating the mTOR Signaling Pathway
Q41099377Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer's Disease
Q90975119Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease
Q39079275Recent advances in molecular biomarkers for diabetes mellitus: a systematic review
Q39010887Recent developments in circulating biomarkers in Parkinson's disease: the potential use of miRNAs in a clinical setting.
Q42293425Retinal and Circulating miRNAs in Age-Related Macular Degeneration: An In vivo Animal and Human Study
Q64084849Small Non-coding RNAs: New Class of Biomarkers and Potential Therapeutic Targets in Neurodegenerative Disease
Q48505093Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity.
Q55135975Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls.
Q41479449Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain
Q41140915The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases.
Q91973221The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice
Q26774431Tumor-Associated CSF MicroRNAs for the Prediction and Evaluation of CNS Malignancies
Q37640781Vincamine Alleviates Amyloid-β 25-35 Peptides-induced Cytotoxicity in PC12 Cells
Q55414815miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer's Disease.
Q89494070miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity
Q39742529miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease
Q39104808miRNAs as biomarkers of neurodegenerative disorders

Search more.