scholarly article | Q13442814 |
P50 | author | Marc-David Ruepp | Q55143880 |
Richard W Farndale | Q61665886 | ||
Iwan J P de Esch | Q89095911 | ||
P2093 | author name string | Andrew J Thompson | |
James A Brozik | |||
Ruth D Murrell-Lagnado | |||
P2860 | cites work | Ligand binding assays at equilibrium: validation and interpretation | Q24629851 |
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Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography † | Q27646546 | ||
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Molecular mechanism of ATP binding and ion channel activation in P2X receptors | Q27678739 | ||
Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet | Q28221012 | ||
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Desensitization masks nanomolar potency of ATP for the P2X1 receptor | Q28578057 | ||
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes. | Q30365580 | ||
Small and colorful stones make beautiful mosaics: fragment-based chemogenomics | Q30425099 | ||
Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice. | Q30560422 | ||
Lessons for fragment library design: analysis of output from multiple screening campaigns | Q30864260 | ||
Molecular complexity and its impact on the probability of finding leads for drug discovery | Q30993107 | ||
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Library design for fragment based screening | Q33221734 | ||
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A ‘Rule of Three’ for fragment-based lead discovery? | Q33973131 | ||
Fragment-based approaches in drug discovery and chemical biology | Q34303994 | ||
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P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice | Q35230316 | ||
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VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors | Q35913156 | ||
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ATP-gated P2X cation-channels | Q37227700 | ||
Calcium signaling in platelets | Q37473529 | ||
P2X purinergic receptor ligands: recently patented compounds | Q37703255 | ||
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An efficient and information-rich biochemical method design for fragment library screening on ion channels | Q39629815 | ||
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Binding thermodynamic characterization of human P2X1 and P2X3 purinergic receptors | Q40036218 | ||
Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop | Q40725974 | ||
Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands | Q40883648 | ||
Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands | Q41738282 | ||
Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening | Q41892145 | ||
Platelet Ca(2+) responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca(2+) stores | Q42326717 | ||
NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors | Q43718770 | ||
Carbamazepine derivatives with P2X4 receptor-blocking activity. | Q43752016 | ||
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Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder | Q46298821 | ||
FlexStation examination of 5-HT3 receptor function using Ca2+ - and membrane potential-sensitive dyes: advantages and potential problems. | Q46614630 | ||
Validation of Alexa-647-ATP as a powerful tool to study P2X receptor ligand binding and desensitization. | Q47907840 | ||
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. | Q48332530 | ||
Single channel properties of P2X ATP receptors in outside-out patches from rat hippocampal granule cells | Q74320313 | ||
Critical review of the role of HTS in drug discovery | Q83039041 | ||
P4510 | describes a project that uses | ImageJ | Q1659584 |
P1104 | number of pages | 9 | |
P304 | page(s) | 13-21 | |
P577 | publication date | 2015-05-28 | |
P1433 | published in | Neuropharmacology | Q15332439 |
P1476 | title | A fluorescent approach for identifying P2X1 ligands | |
P478 | volume | 98 |
Q33843023 | Unraveling the Thousand Word Picture: An Introduction to Super-Resolution Data Analysis | cites work | P2860 |
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