Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility

scientific article published on 14 October 2011

Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1124/JPET.111.186213
P932PMC publication ID3251021
P698PubMed publication ID22001258
P5875ResearchGate publication ID51719070

P2093author name stringGeorgi V Petkov
Kiril L Hristov
Shankar P Parajuli
Rupal P Soder
P2860cites workCa(2+)-activated K+ channels: molecular determinants and function of the SK familyQ28283065
Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)Q28286744
Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureQ33379783
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscleQ33956291
Voltage-gated K(+) channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscleQ33995024
Urinary bladder contraction and relaxation: physiology and pathophysiologyQ34335220
Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinenceQ34376940
Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cellsQ34947794
Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channelsQ35116083
Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3Q35205602
Large-conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle functionQ35321958
Ion channels and control of contractile activity in urinary bladder smooth muscleQ35332935
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogsQ35657955
Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity?Q35687961
Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscleQ35703903
Newer agents for the management of overactive bladder.Q36691401
Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel.Q36956755
Stimulation of beta3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channelsQ36977701
Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladderQ37002438
The intermediate-conductance Ca2+ -activated K+ channel (KCa3.1) in vascular disease.Q37370289
A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivoQ39935313
Differential regulation of Ca2+-activated K+ channels by beta-adrenoceptors in guinea pig urinary bladder smooth muscleQ42646332
Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladderQ43263269
Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladderQ43569494
Differential regulation of SK and BK channels by Ca(2+) signals from Ca(2+) channels and ryanodine receptors in guinea-pig urinary bladder myocytesQ44013268
Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channelQ44482226
Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertensionQ46043760
Negative feedback regulation of nerve-mediated contractions by KCa channels in mouse urinary bladder smooth muscleQ46450249
Mechanisms of excitatory neuromuscular transmission in the guinea-pig urinary bladderQ46948162
Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats.Q51792243
Mechanism of calcium gating in small-conductance calcium-activated potassium channels.Q54432027
Electrical and mechanical responses produced by nerve stimulation in detrusor smooth muscle of the guinea-pigQ70868685
SK4 encodes intermediate conductance Ca2+-activated K+ channels in mouse urinary bladder smooth muscle cellsQ73106493
Ca(2+)-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscleQ73575583
Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channelsQ74008351
Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscleQ77316917
Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscleQ83167978
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)114-123
P577publication date2011-10-14
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titlePharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility
P478volume340

Reverse relations

cites work (P2860)
Q61660281A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle
Q50207105A simple, rapid, and efficient method for isolating detrusor for the culture of bladder smooth muscle cells
Q37663366BK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function
Q34201175Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology
Q58557816Effect of high-fat diet-induced obesity on the small-conductance Ca-activated K channel function affecting the contractility of rat detrusor smooth muscle
Q37595319Electrophysiology of human cardiac atrial and ventricular telocytes
Q35156822Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4
Q34379862Ethanol-mediated relaxation of guinea pig urinary bladder smooth muscle: involvement of BK and L-type Ca2+ channels
Q36041658Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle
Q47791076Expression and function of the small-conductance Ca2+-activated K+ channel is decreased in urinary bladder smooth muscle cells from female guinea pig with partial bladder outlet obstruction
Q46790305Functional expression of SK channels in murine detrusor PDGFR+ cells
Q64913933Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice.
Q90287433Involvement of transient receptor potential melastatin 4 channels in the resting membrane potential setting and cholinergic contractile responses in mouse detrusor and ileal smooth muscles
Q27013943Ion channels of the mammalian urethra
Q35000941Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle
Q38994844Myocardial Telocytes: A New Player in Electric Circuitry of the Heart
Q36709228NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels
Q36699604Novel role for the transient potential receptor melastatin 4 channel in guinea pig detrusor smooth muscle physiology
Q46162521Partial bladder outlet obstruction is associated with decreased expression and function of the small-conductance Ca2+-activated K+ channel in guinea pig detrusor smooth muscle
Q52631909Pharmacologic targeting of endothelial Ca2+-activated K+ channels: A strategy to improve cardiovascular function.
Q89741226Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents
Q90634790Properties of single-channel and whole cell Cl- currents in guinea pig detrusor smooth muscle cells
Q44212098Purinergic inhibitory regulation of murine detrusor muscles mediated by PDGFRα+ interstitial cells
Q34029764Role of potassium ion channels in detrusor smooth muscle function and dysfunction
Q36175950SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions
Q36528023SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle
Q36382456Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation
Q48114005Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.
Q36764277TRPM4 channel: a new player in urinary bladder smooth muscle function in rats
Q36066396UTP activates small-conductance Ca2+-activated K+ channels in murine detrusor PDGFRα+ cells

Search more.