Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis

scientific article published on 8 June 2015

Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1029217S
P356DOI10.1371/JOURNAL.PONE.0129217
P932PMC publication ID4460035
P698PubMed publication ID26053248
P5875ResearchGate publication ID278698836

P50authorFerenc GallyasQ69362491
Krisztián KvellQ74598655
Zsolt IllesQ87617327
P2093author name stringPeter Acs
Katalin Fekete
Arpad Szanto
Gergely Talaber
Izabella Solti
Petra Zalan
Sara Veto
Zita Bognar
P2860cites workWnt4 and LAP2alpha as pacemakers of thymic epithelial senescenceQ21136364
Transcriptional regulation by AIRE: molecular mechanisms of central toleranceQ24648384
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin VQ28294206
Cell biology. Metabolic control of cell deathQ28397089
Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelinationQ29614990
Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methodsQ33920115
Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.Q34059078
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system.Q34122755
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.Q34242985
Phagocytic properties of microglia in vitro: implications for a role in multiple sclerosis and EAE.Q34309554
Experimental models of multiple sclerosisQ34580814
Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.Q35106636
Microglial recruitment, activation, and proliferation in response to primary demyelinationQ35757235
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytesQ36205075
Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic miceQ36365670
Normal structure, function and histology of the thymusQ36635918
The origin and application of experimental autoimmune encephalomyelitisQ36961600
The thymus is a common target in malnutrition and infectionQ36964958
MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseasesQ37108372
The cuprizone model for demyelinationQ37148502
Multiple sclerosis and regulatory T cellsQ37258383
The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia.Q51113861
Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation.Q51736194
E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation.Q52112832
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorshipQ57338704
Effect of cuprizone on copper exchange and superoxide dismutase activity in rat liverQ71476628
Case for the panel. Mitochondrial inclusions in prostate adenocarcinomaQ73632902
Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination modelQ87154965
The lysosome and neurodegenerative diseasesQ37508715
Disturbed regulatory T cell homeostasis in multiple sclerosis.Q37693444
In vitro and in vivo models of multiple sclerosisQ38009921
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The roles of cyclic AMP-ERK-Bad signaling pathways on 6-hydroxydopamine-induced cell survival and death in PC12 cellsQ39093329
Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: a new mechanism for the cytoplasmic effect of PARP-1 activation.Q39648230
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Q40662652
The role of T cells in multiple sclerosis: implications for therapies targeting the T cell receptorQ40666827
Division of giant mitochondria during recovery from cuprizone intoxicationQ41158949
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitisQ41433234
Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone)Q41573881
Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitroQ41665140
MHC class II exacerbates demyelination in vivo independently of T cellsQ42080688
Enzymic activities and sodium, potassium and copper concentrations in mouse brain and liver after cuprizone treatment in vivoQ43678756
Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL miceQ43755777
Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosisQ45359704
Selective ultrastructural vulnerability in the cuprizone-induced experimental demyelination.Q48332577
Experimental demyelination caused by primary oligodendrocyte dystrophy. Regional distribution of the lesions in the nervous system of mice [corrected].Q48892732
Giant hepatic mitochondria: production in mice fed with cuprizoneQ49073075
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectthymocyteQ7799635
cuprizoneQ27262585
P304page(s)e0129217
P577publication date2015-06-08
P1433published inPLOS OneQ564954
P1476titleThymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis
P478volume10

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cites work (P2860)
Q90638165CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis
Q61805331Correlation Between Smoking and Passive Smoking with Multiple Sclerosis and the Underlying Molecular Mechanisms
Q103015215Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment
Q52338686Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice.
Q58122911Immune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyelitis Mouse Model
Q47126451PPARgamma Deficiency Counteracts Thymic Senescence.
Q58797927Strain differences in thymic atrophy in rats immunized for EAE correlate with the clinical outcome of immunization
Q64093062Transgenic Exosomes for Thymus Regeneration

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