Antifungal pharmacokinetics and pharmacodynamics

scientific article published on 10 November 2014

Antifungal pharmacokinetics and pharmacodynamics is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1101/CSHPERSPECT.A019653
P932PMC publication ID4448584
P698PubMed publication ID25384765

P50authorDavid AndesQ75205210
P2093author name stringAlexander J Lepak
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Antifungal therapeutic drug monitoring: established and emerging indicationsQ37310029
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Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus.Q37335649
THE SLOW RECOVERY OF BACTERIA FROM THE TOXIC EFFECTS OF PENICILLIN.Q37376712
Diagnostic imaging of experimental invasive pulmonary aspergillosisQ37404687
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Protein binding of antimicrobials: clinical pharmacokinetic and therapeutic implicationsQ37712057
Exposure-response of posaconazole used for prophylaxis against invasive fungal infections: evaluating the need to adjust doses based on drug concentrations in plasmaQ37761047
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Treatment of endogenous fungal endophthalmitis: focus on new antifungal agentsQ37829260
Protein binding: do we ever learn?Q37871252
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Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antibacterial agentsQ37927017
Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials.Q37993043
The Eagle-like effect of echinocandins: what's in a name?Q38153458
Protein binding and its significance in antibacterial therapyQ38681616
Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B.Q39472116
Pharmacokinetics and safety of voriconazole following intravenous- to oral-dose escalation regimensQ39652421
Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosisQ39652561
Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbitsQ39851052
Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofunginQ39895162
Influence of binding on the pharmacologic activity of antibioticsQ39899627
Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrationsQ39954432
Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapyQ40186278
Continuous and 4 h infusion of amphotericin B: a comparative study involving high-risk haematology patients.Q40528020
In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model.Q36425025
Bone marrow toxicity associated with 5-fluorocytosine therapyQ36459546
Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.Q36482821
Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosisQ36505539
In vitro interaction of voriconazole and anidulafungin against triazole-resistant Aspergillus fumigatus.Q36558484
Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosisQ36584655
Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative cultureQ36744831
Inhibitory and fungicidal effects of antifungal drugs against Aspergillus species in the presence of serumQ36757617
Pharmacodynamics and dose-response relationships of liposomal amphotericin B against different azole-resistant Aspergillus fumigatus isolates in a murine model of disseminated aspergillosisQ36757621
Pharmacokinetics and pharmacodynamics of antimicrobialsQ36854798
Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida infections. Subcommittee on Antifungal Susceptibility TeQ36855581
Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrationsQ36856930
Association of fluconazole pharmacodynamics with mortality in patients with candidemiaQ36870712
Activity of posaconazole in treatment of experimental disseminated zygomycosis.Q36880761
Toxicity of amphotericin B plus flucytosine in 194 patients with cryptococcal meningitisQ33449819
Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene.Q33613758
Assessment of antifungal activities of fluconazole and amphotericin B administered alone and in combination against Candida albicans by using a dynamic in vitro mycotic infection modelQ33693370
Pharmacodynamics of fluconazole in a murine model of systemic candidiasis.Q33695281
Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthaseQ33754208
Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic miceQ33806127
Correlation between in vitro activity of posaconazole and in vivo efficacy against Rhizopus oryzae infection in miceQ33826450
Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria.Q33830384
In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida speciesQ33876423
Population pharmacokinetics of micafungin in neonates and young infantsQ33876608
Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous systemQ33908389
Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia.Q33938082
Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection modelQ33977551
In vivo characterization of the pharmacodynamics of flucytosine in a neutropenic murine disseminated candidiasis modelQ33979115
Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformansQ33979304
In vivo activity of amphotericin B lipid complex in immunocompromised mice against fluconazole-resistant or fluconazole-susceptible Candida tropicalisQ33980705
Clinical correlates of antifungal macrodilution susceptibility test results for non-AIDS patients with severe Candida infections treated with fluconazole.Q33980741
Dosage-dependent antifungal efficacy of V-echinocandin (LY303366) against experimental fluconazole-resistant oropharyngeal and esophageal candidiasisQ33981387
Pharmacodynamics of amphotericin B in a neutropenic-mouse disseminated-candidiasis modelQ33981712
Pharmacokinetic and pharmacodynamic modeling of anidulafungin (LY303366): reappraisal of its efficacy in neutropenic animal models of opportunistic mycoses using optimal plasma samplingQ33983159
Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetateQ33983618
Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasisQ34006585
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.Q34020746
Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemiaQ34104748
Rates and extents of antifungal activities of amphotericin B, flucytosine, fluconazole, and voriconazole against Candida lusitaniae determined by microdilution, Etest, and time-kill methods.Q34105231
Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbitsQ34108880
Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activityQ34228214
In vitro activity of micafungin (FK-463) against Candida spp.: microdilution, time-kill, and postantifungal-effect studiesQ34253266
Impact of cyp51A mutations on the pharmacokinetic and pharmacodynamic properties of voriconazole in a murine model of disseminated aspergillosisQ34290034
Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'.Q34307105
Pharmacodynamic activity of amphotericin B deoxycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosisQ34352109
Pharmacokinetic-pharmacodynamic comparison of amphotericin B (AMB) and two lipid-associated AMB preparations, liposomal AMB and AMB lipid complex, in murine candidiasis modelsQ34352186
Correlation of MIC with outcome for Candida species tested against voriconazole: analysis and proposal for interpretive breakpointsQ34431984
Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungiQ34455495
The yeast cell-wall salvage pathwayQ34500169
Evaluation of amphotericin B interpretive breakpoints for Candida bloodstream isolates by correlation with therapeutic outcomeQ34510359
Multidimensional volumetric imaging of pulmonary infiltrates for measuring therapeutic response to antifungal therapy in experimental invasive pulmonary aspergillosisQ34510443
Characterization and comparison of galactomannan enzyme immunoassay and quantitative real-time PCR assay for detection of Aspergillus fumigatus in bronchoalveolar lavage fluid from experimental invasive pulmonary aspergillosisQ34719835
Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapyQ34754956
In vivo pharmacodynamics of HMR 3270, a glucan synthase inhibitor, in a murine candidiasis modelQ34881309
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis modelQ34881676
Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasisQ35007030
In vivo pharmacodynamics of antifungal drugs in treatment of candidiasisQ35091285
Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulationsQ35091593
Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: enhanced ability to detect amphotericin B-resistant Candida isolatesQ35120311
Anidulafungin pharmacokinetics and microbial response in neutropenic mice with disseminated candidiasisQ35127833
Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effectQ35127913
Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.Q35136891
Observational study of the clinical efficacy of voriconazole and its relationship to plasma concentrations in patientsQ35270270
Liposomal and lipid formulations of amphotericin B. Clinical pharmacokineticsQ35372178
Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitisQ35535337
Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulationQ35582365
Clinical pharmacodynamics of antifungals.Q35623090
Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemiaQ35635693
Once-weekly micafungin therapy is as effective as daily therapy for disseminated candidiasis in mice with persistent neutropeniaQ35647785
Anidulafungin for neonatal hematogenous Candida meningoencephalitis: identification of candidate regimens for humans using a translational pharmacological approach.Q35689202
Comparative analysis of amphotericin B lipid complex and liposomal amphotericin B kinetics of lung accumulation and fungal clearance in a murine model of acute invasive pulmonary aspergillosis.Q35758926
Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detectionQ35806998
Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrataQ35867789
Clinical utility of antifungal pharmacokinetics and pharmacodynamics.Q36004448
In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model.Q36048229
Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosingQ36094957
Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemiaQ36094974
Monitoring and impact of fluconazole serum and cerebrospinal fluid concentration in HIV-associated cryptococcal meningitis-infected patientsQ36161724
Pharmacodynamics of itraconazole against Aspergillus fumigatus in an in vitro model of the human alveolus: perspectives on the treatment of triazole-resistant infection and utility of airway administration.Q36171643
Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012Q36172242
Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutationsQ36364100
Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.Q40668367
In vitro interactions between amphotericin B, itraconazole, and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction modelsQ40882541
In vitro pharmacodynamics of amphotericin B, itraconazole, and voriconazole against Aspergillus, Fusarium, and Scedosporium sppQ41091429
Assessment of efficacy of antifungals against Aspergillus fumigatus: value of real-time bioluminescence imaging.Q41441699
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.Q41696128
The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans.Q41810708
Combination echinocandin-polyene treatment of murine mucormycosisQ41904884
Clinical pharmacodynamic index identification for micafungin in esophageal candidiasis: dosing strategy optimization.Q41929256
Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serumQ41963359
Posaconazole prophylaxis in experimental systemic zygomycosisQ42078170
Assessment of the paradoxical effect of caspofungin in therapy of candidiasisQ42090519
Changes in cell wall synthesis and ultrastructure during paradoxical growth effect of caspofungin on four different Candida species.Q42111171
Posaconazole mono- or combination therapy for treatment of murine zygomycosisQ42183489
Efficacy of caspofungin and voriconazole combinations in experimental aspergillosis.Q42286250
Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effectQ42577557
New drugs for the systemic mycoses: flucytosine and clotrimazoleQ43056358
Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae.Q43189988
The effects of an hsp90 inhibitor on the paradoxical effectQ43275008
Assessment of micafungin regimens by pharmacokinetic-pharmacodynamic analysis: a dosing strategy for Aspergillus infectionsQ43287630
Continuous infusion of escalated doses of amphotericin B deoxycholate: an open-label observational studyQ44396642
Evaluation of the post-antifungal effect (PAFE) of amphotericin B and nystatin against 30 zygomycetes using two different media.Q44459191
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandinQ44469440
Clinical factors associated with fluconazole resistance and short-term survival in patients with Candida bloodstream infectionQ44866472
Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosisQ45063490
Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activityQ45066131
Continuous infusion of amphotericin B deoxycholate for the treatment of life-threatening Candida infections.Q45399160
A Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis.Q46023744
Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009).Q46306343
Studies of the paradoxical effect of caspofungin at high drug concentrationsQ46377599
Comparison of the EUCAST-AFST broth dilution method with the CLSI reference broth dilution method (M38-A) for susceptibility testing of posaconazole and voriconazole against Aspergillus spp.Q46444751
Twenty-four hour continuous infusion of amphotericin B for the treatment of suspected or proven fungal infection in haematology patientsQ46489287
Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosisQ46729762
Efficacy of high loading doses of liposomal amphotericin B in the treatment of experimental invasive pulmonary aspergillosisQ46819795
Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosisQ46971553
Pharmacodynamics of voriconazole in a dynamic in vitro model of invasive pulmonary aspergillosis: implications for in vitro susceptibility breakpoints.Q47568169
In vitro model of invasive pulmonary aspergillosis in the human alveolusQ47571487
Candida urinary tract infections--treatment.Q51175452
Comparative in vivo dose-dependent activity of caspofungin and anidulafungin against echinocandin-susceptible and -resistant Aspergillus fumigatus.Q51175502
The efficacy of voriconazole in the treatment of 192 fungal central nervous system infections: a retrospective analysis.Q52896107
In vitro interaction of fluconazole and amphotericin B administered sequentially against Candida albicans: effect of concentration and exposure time.Q53727517
Comparison of three methodologies for the determination of pulmonary fungal burden in experimental murine aspergillosis.Q54614663
EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia–forming mouldsQ56837279
Flucytosine therapeutic monitoring: 15 years experience from the UKQ56837289
Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosisQ56993324
The postantibiotic effectQ69011396
Antifungal prophylaxis with itraconazole in prolonged neutropenia: correlation with plasma levelsQ69365263
Postantibiotic effectsQ70073524
In vivo postantibiotic effect in a thigh infection in neutropenic miceQ70370760
The postantibiotic effect of antifungal agents against common pathogenic yeastsQ72807287
In vitro pharmacodynamic characteristics of flucytosine determined by time-kill methodsQ73516074
Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlationQ80231148
P433issue5
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)a019653
P577publication date2014-11-10
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleAntifungal pharmacokinetics and pharmacodynamics
P478volume5