Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse

scientific article published on 19 October 2011

Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.05590-11
P932PMC publication ID3255863
P698PubMed publication ID22013038

P50authorDavid M. MargolisQ37380199
Nancie M ArchinQ106613342
P2093author name stringJ Victor Garcia
Shailesh K Choudhary
Noelle P Dahl
Manzoor Cheema
P2860cites workResting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapyQ34857454
A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapyQ34990151
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cellsQ35007831
Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cellsQ35076645
Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- miceQ35127565
Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivoQ35149006
Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradicationQ35158133
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 proteinQ35211232
HIV-1 infection and pathogenesis in a novel humanized mouse modelQ35750948
Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infectionQ36225040
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapyQ36499290
Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a yearQ36756422
Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokinesQ36851755
Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gaQ37275103
Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cellsQ37393518
HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse modelQ38905274
Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infectionQ39686599
Generation of HIV latency during thymopoiesisQ44072849
Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1.Q46738531
Development of a human adaptive immune system in cord blood cell-transplanted miceQ47819239
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.Q52007779
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.Q53592113
Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART.Q53869061
Persistence of replication-competent HIV in the central nervous system despite long-term effective highly active antiretroviral therapyQ81314113
An improvement in virologic response to highly active antiretroviral therapy in clinical practice from 1996 through 2002Q81767493
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cellsQ24548940
Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acidQ24596282
Primitive hematopoietic cells resist HIV-1 infection via p21Q24681819
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of diseaseQ28267375
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
Multiple blocks to human immunodeficiency virus type 1 replication in rodent cellsQ33603453
A block to human immunodeficiency virus type 1 assembly in murine cellsQ33802821
Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitorsQ33957283
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoirQ34097573
Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- miceQ34100221
Molecular Characterization, Reactivation, and Depletion of Latent HIVQ34263657
Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapyQ34588169
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)114-120
P577publication date2011-10-19
P1433published inJournal of VirologyQ1251128
P1476titleLatent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse
P478volume86

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