β-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages.

scientific article published on 18 November 2011

β-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.297887
P932PMC publication ID3256862
P698PubMed publication ID22102286

P50authorMichiko T. YasudaQ41204617
P2093author name stringXiaojuan Xu
Masashi Mizuno
Sachiko Nakamura-Tsuruta
Hitoshi Ashida
P2860cites workTLR4 mutations are associated with endotoxin hyporesponsiveness in humansQ22254186
Molecular mechanism of tumor necrosis factor-alpha production in 1-->3-B-glucan (zymosan)-activated macrophagesQ23921364
The L-arginine-nitric oxide pathwayQ24304874
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signalingQ24309107
A protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Dectin-1: a signalling non-TLR pattern-recognition receptorQ28286159
Dectin-1 mediates the biological effects of beta-glucansQ28509437
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectinsQ28588506
Nitric oxide and macrophage functionQ29615327
Nitric oxide and the immune responseQ29617591
Nitric oxide as a secretory product of mammalian cellsQ29620372
Therapeutic intervention with complement and beta-glucan in cancerQ33688574
Therapeutic effects of nitric oxide inhibition during experimental fecal peritonitis: role of interleukin-10 and monocyte chemoattractant protein 1.Q33750360
Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extractsQ33789157
Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.Q33937171
Novel effects of nitric oxideQ34192694
Roles of Toll-like receptors in innate immune responsesQ34368121
DNA deaminating ability and genotoxicity of nitric oxide and its progenitorsQ34983829
Immunomodulatory beta-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclear factor-kappaB in murine RAW 264.7 macrophagesQ35213064
Fungal β-Glucans and Mammalian ImmunityQ35538040
Dectin-1 is required for beta-glucan recognition and control of fungal infectionQ35837153
Immune recognition of fungal beta-glucansQ36067620
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated miceQ36352474
Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophagesQ78148082
Identification of a reticuloendothelial stimulating agent in zymosanQ78994089
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.Q36370968
Overview of (1-->3)-beta-D-glucan immunobiologyQ37160328
TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common themeQ37184150
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophagesQ37675736
Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.Q38287424
Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophagesQ38302447
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthaseQ38311029
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharideQ38318972
Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase geneQ38336552
An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharideQ38349380
Lentinan has a stimulatory effect on innate and adaptive immunity against murine Listeria monocytogenes infectionQ40310914
Inhibition of LPS-induced NO production by taurine chloramine in macrophages is mediated though Ras-ERK-NF-kappaB.Q40372057
Regulation of lymphocyte functions by nitric oxideQ40404893
Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophagesQ40657235
Inhibition of NF-kappa B/Rel nuclear translocation by dexamethasone: mechanism for the inhibition of iNOS gene expression.Q41022107
TNF alpha is important in human lung allergic reactionsQ41189628
Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.Q41468527
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharideQ41578065
The role of beta-glucan receptors on blood and tissue leukocytes in phagocytosis and metabolic activationQ42013662
Nitric oxide induces apoptosis in mouse thymocytes.Q42277929
(1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophagesQ43084855
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infectionQ43831403
Regulation of the expression of inducible nitric oxide synthaseQ45089049
Effects of lentinan on cytotoxic functions of human lymphocytesQ46379036
Macrophages and nitric oxide: A deadly combinationQ46682112
Down-regulation of tumor necrosis factor-alpha, moderate reduction of interleukin-1beta, but not interleukin-6 or interleukin-10, by glucan immunomodulators curdlan sulfate and lentinanQ47937667
Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cellsQ48040720
Antitumor activity of lentinan in murine syngeneic and autochthonous hosts and its suppressive effect on 3-methylcholanthrene-induced carcinogenesis.Q53549387
The effect of lentinan on production of interleukin-1 by human monocytes.Q53564061
Regulation of iNOS expression and glutathione levels in rat liver by oxygen tensionQ58317019
Antitumor action of shiitake (Lentinus edodes) fruit bodies orally administered to miceQ69419651
Antitumor mechanisms of orally administered shiitake fruit bodiesQ69419653
Effect of lentinan and mannan on phagocytosis of fluorescent latex microbeads by mouse peritoneal macrophages: a flow cytometric studyQ69784394
Monoclonal antibody-dependent murine macrophage-mediated cytotoxicity against human tumors is stimulated by lentinanQ69938961
Clinical evaluation of schizophyllan combined with irradiation in patients with cervical cancer. A randomized controlled studyQ69996308
Effect of lentinan on macrophage cytotoxicity against metastatic tumor cellsQ70541121
Conformation dependency of nitric oxide synthesis of murine peritoneal macrophages by beta-glucans in vitroQ71698470
Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxiaQ71735229
Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinanQ73049063
Acute hypoxia upregulates NOS gene expression in ratsQ73757825
Enhanced production of inducible nitric oxide synthase by beta-glucans in miceQ73934276
Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa BQ74065482
Inducible nitric oxide synthase in human diseasesQ77151701
Inducible nitric oxide synthase in the liver: regulation and functionQ77165703
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectlipopolysaccharideQ421804
Lentinus edodesQ105057495
P304page(s)871-878
P577publication date2011-11-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleβ-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages
P478volume287

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cites work (P2860)
Q30658500A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.
Q41661833Anti-Inflammatory Effects of a Mytilus coruscus α-d-Glucan (MP-A) in Activated Macrophage Cells via TLR4/NF-κB/MAPK Pathway Inhibition.
Q37049848Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism
Q53365576Effect of β-glucan originated from Aureobasidium pullulans on asthma induced by ovalbumin in mouse.
Q38109156Immunomodulating compounds in Basidiomycetes
Q47152127Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit.
Q38884940Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice.

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