Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias

scientific article published on 28 November 2011

Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/CIRCULATIONAHA.111.056309
P932PMC publication ID3258098
P698PubMed publication ID22124376
P5875ResearchGate publication ID51833409

P50authorJeanine M. D'ArmientoQ92638620
John P. MorrowQ37370090
Takayuki ShiomiQ42149086
P2093author name stringShunichi Homma
Ira J Goldberg
Haiyan Huang
Chad M Trent
Steven O Marx
Carolina Vasquez
Gregory E Morley
Joshua M Lader
Alexander Katchman
Ni-Huiping Son
Raffay Khan
Vaibhav Amin
P2860cites workImproved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptorQ24598147
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitusQ28344691
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43Q28506915
Mouse models of long QT syndromeQ33154363
Isolation and culture of adult mouse cardiac myocytesQ64377366
Diabetes as a risk factor for sudden deathQ73327106
Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmicQ73764581
Predicting sudden death in the population: the Paris Prospective Study IQ77342545
Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractorinessQ77402063
Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazoneQ34123137
Modulation of cardiac gap junction expression and arrhythmic susceptibility.Q34207091
Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities studyQ34720019
Role of PPARgamma in macrophage biology and atherosclerosisQ35947670
Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in miceQ35970883
Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytesQ36420431
Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventriclesQ36464438
Diabetic cardiomyopathy revisitedQ36860318
Adaptation and maladaptation of the heart in obesityQ36862876
PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy.Q36961179
Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in AmericaQ36968866
Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse heartsQ37304993
Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndromeQ37382176
Echocardiographic assessment of global left ventricular function in miceQ37399761
PPAR-gamma expression in animals subjected to volume overload and chronic Urotensin II administrationQ37422701
Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c).Q39827153
Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation.Q40804479
Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunitQ40925692
Oxidative stress and inflammation modulate peroxisome proliferator-activated receptors with regional discrepancy in diabetic heartQ43012962
Heart rate-corrected QT interval in resting ECG predicts the risk for development of type-2 diabetes mellitusQ43196859
PPAR(gamma)/PGC-1(alpha) pathway in E-cadherin expression and motility of HepG2 cells.Q43203729
Patients with metabolic syndrome have prolonged corrected QT interval (QTc).Q43219074
Serum glucose and insulin are associated with QTc and RR intervals in nondiabetic elderlyQ43246235
Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery diseaseQ44316923
Phytanic acid accumulation is associated with conduction delay and sudden cardiac death in sterol carrier protein-2/sterol carrier protein-x deficient miceQ45169843
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathyQ45200908
Peroxisome proliferator-activated receptor agonists modulate heart function in transgenic mice with lipotoxic cardiomyopathyQ45238740
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.Q45985589
Anti-inflammatory and antidiabetic roles of PPARgamma.Q46059037
Out of hospital sudden cardiac death in Italy: a population-based case-control studyQ46599127
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in miceQ46624714
Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventriclesQ47350584
Prospective study of sudden cardiac death among women in the United StatesQ47973912
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.Q50782443
Association of fasting plasma free fatty acid concentration and frequency of ventricular premature complexes in nonischemic non-insulin-dependent diabetic patients.Q50921783
Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.Q51033472
Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients.Q51055195
Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes.Q52132199
Activation of peroxisome proliferator-activated receptor-alpha and -gamma in auricular tissue from heart failure patients.Q54640549
Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mappingQ59241313
P4510describes a project that usesImageJQ1659584
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)2812-2821
P577publication date2011-11-28
P1433published inCirculationQ578091
P1476titleMice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias
P478volume124

Reverse relations

cites work (P2860)
Q37458369Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.
Q33820434Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial Fibrillation
Q34997831Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice
Q34396881Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure
Q60919578Clinical Overview of Obesity and Diabetes Mellitus as Risk Factors for Atrial Fibrillation and Sudden Cardiac Death
Q36520404Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice
Q36824078Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels
Q92497947Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
Q54313312Ectopic overexpression of swine PPARγ2 upregulated adipocyte genes expression and triacylglycerol in skeletal muscle of mice.
Q35826487Effects of C-reactive protein on K(+) channel interaction protein 2 in cardiomyocytes.
Q92814856Effects of granulocyte colony‑stimulating factor on rabbit carotid and porcine heart models of chronic obliterative arterial disease
Q52866707Genetic variations involved in sudden cardiac death and their associations and interactions.
Q38944506Impact of di-ethylhexylphthalate exposure on metabolic programming in P19 ECC-derived cardiomyocytes.
Q42367636Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function.
Q35891484Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes
Q60046474Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
Q37684850Lipid Use and Misuse by the Heart.
Q47130392Low density lipoprotein - rosiglitazone - chitosan-calcium alginate/nanoparticles inhibition of human tenon's fibroblasts activation and proliferation
Q36328486Metabolic stress in the myocardium: adaptations of gene expression.
Q42407406Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia
Q28068153Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus
Q90108849PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction
Q39136593Rosiglitazone-loaded nanospheres for modulating macrophage-specific inflammation in obesity
Q35126015Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity
Q98177423Shensong Yangxin Protects Against Metabolic Syndrome-Induced Ventricular Arrhythmias by Inhibiting Electrical Remodeling

Search more.