Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1. (scientific article published on 28 September 2011)

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta

Q77388281

Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis

Q80974232

Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome

Q82755602

Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor

Q28252870

The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?

Q28361886

Pigment epithelium–derived factor regulates the vasculature and mass of the prostate and pancreas

Q28513340

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

Q28513856

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

Q28568441

Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy

Q28577207

A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II

Q28583200

Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo.

Q33196731

Heparin binding induces a conformational change in pigment epithelium-derived factor

Q33268108

Cytokines and fibrogenesis

Q33697040

Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator

Q33708754

Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization

Q33808055

The Calreticulin-Binding Sequence of Thrombospondin 1 Regulates Collagen Expression and Organization During Tissue Remodeling

Q34162333

Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells

Q34162379

Thrombospondins as matricellular modulators of cell function

Q34221349

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

Q35011868

Regulating the angiogenic balance in tissues

Q35062979

Identification of a novel inhibitor of the canonical Wnt pathway

Q35096644

Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors

Q35568530

Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis

Q35788265

The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice

Q35789152

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.

Q36805212

Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis

Q37100243

Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer

Q39609086

Pancreatic stellate cells: partners in crime with pancreatic cancer cells

Q39996299

Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities

Q40274424

Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice

Q40338976

Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts

Q40668890

Administration of pigment epithelium-derived factor inhibits left ventricular remodeling and improves cardiac function in rats with acute myocardial infarction

Q41094344

Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences

Q41391791

Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta

Q44989718

Vitamin A up-regulates the expression of thrombospondin-1 and pigment epithelium-derived factor in retinal pigment epithelial cells

Q45225693

Pigment epithelium-derived factor contributes to insulin resistance in obesity.

Q45936847

Induced thrombospondin expression in the mouse pancreas during pancreatic injury

Q46718708

Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma

Q47585945

Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin

Q48058006

Pigment epithelium-derived factor is a niche signal for neural stem cell renewal

Q48642193

Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.

Q53326694

Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice

Q70912616

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P1104

number of pages

P304

page(s)

2990-2999

P577

publication date

2011-09-28

P1433

published in

The American Journal of Pathology

Q4744259

P1476

title

Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.

P478

volume

179

Reverse relations

cites work (P2860)

Q36465542	Administration of Pigment Epithelium-Derived Factor Inhibits Airway Inflammation and Remodeling in Chronic OVA-Induced Mice via VEGF Suppression
Q28067001	Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review
Q37245971	Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content
Q28820963	Emetine Di-HCl attenuates Type 1 diabetes mellitus in mice
Q53400319	Induction of chronic pancreatitis by pancreatic duct ligation activates BMP2, apelin, and PTHrP expression in mice.
Q60300693	Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats
Q38663596	Intra-articular Injection of a Substance P Inhibitor Affects Gene Expression in a Joint Contracture Model.
Q36918170	Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts
Q27026916	PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases
Q41354166	PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction
Q37051499	Pancreatitis activates pancreatic apelin-APJ axis in mice
Q36157238	Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver
Q38847977	Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease
Q41956357	Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling
Q41878827	Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade
Q51029813	Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.
Q52875108	Transplantation of Human Urine-Derived Stem Cells Transfected with Pigment Epithelium-Derived Factor to Protect Erectile Function in a Rat Model of Cavernous Nerve Injury.