Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats

scientific article published on 6 July 2015

Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1030764F
P356DOI10.1371/JOURNAL.PONE.0130764
P932PMC publication ID4493112
P698PubMed publication ID26147379
P5875ResearchGate publication ID279787358

P50authorAna Fernandez-BustamanteQ51824997
P2093author name stringPaul Wilson
Paul E Wischmeyer
John E Repine
Amanda Agazio
Angela F D Moss
Kaily A Baer
Luke Domaleski
Nancy Elkins
Qianbin He
P2860cites workMetabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophagesQ41822196
Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation.Q41952087
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Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobinQ50337467
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Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats.Q51042965
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Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgeryQ79346307
Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and diseaseQ80991633
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animalsQ84005909
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Glutamine protects ischemia-reperfusion induced acute lung injury in isolated rat lungsQ84674883
Alanyl-glutamine resolves lipopolysaccharide-induced lung injury in mice by modulating the polarization of regulatory T cells and T helper 17 cellsQ86447416
Intravenous glutamine administration reduces lung and distal organ injury in malnourished rats with sepsisQ87107645
Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal miceQ87417217
Exploring the full spectrum of macrophage activationQ24653754
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The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavengingQ26864505
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Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activationQ34317619
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Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury.Q35219775
Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone.Q36142511
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P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injuryQ36953234
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Pulmonary macrophage subpopulations in the induction and resolution of acute lung injuryQ37591016
Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapyQ37714121
Glutamine-containing dipeptides in parenteral nutritionQ37824899
CD163 and its expanding functional repertoireQ37981772
Alveolar macrophages: plasticity in a tissue-specific contextQ38180346
Decreased plasma glutamine level and CD4+ T cell number in response to 8 wk of anaerobic trainingQ38557724
Hyperoxia stimulates alveolar macrophages to produce and release a factor which increases neutrophil adherenceQ38583604
Prostaglandins as negative regulators against lipopolysaccharide, lipoteichoic acid, and peptidoglycan-induced inducible nitric oxide synthase/nitric oxide production through reactive oxygen species-dependent heme oxygenase 1 expression in macrophagQ39264559
Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury modelsQ39356579
Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factorQ39679119
The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform.Q40254142
Oral glutamine enhances heat shock protein expression and improves survival following hyperthermiaQ40483341
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectneutrophil recruitmentQ106615276
P304page(s)e0130764
P577publication date2015-07-06
P1433published inPLOS OneQ564954
P1476titleBrief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats
P478volume10

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cites work (P2860)
Q26767206Exogenous Glutamine in Respiratory Diseases: Myth or Reality?
Q90239080Glutamine Therapy Reduces Inflammation and Extracellular Trap Release in Experimental Acute Respiratory Distress Syndrome of Pulmonary Origin

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