Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review

scientific article published on June 2015

Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/BCP.12564
P932PMC publication ID4456120
P698PubMed publication ID25444240

P2093author name stringMaria Mônica Studart Mendes Moreira
Rosimary de Sousa Carvalho
Ricardo Souza Martins
Mario Roberto Pontes Lisboa
Icrólio Ribeiro Colares Terceiro
Ilanna Mara Gomes Estanislau
Patrícia de Barros Teles
P2860cites workPleiotropic effects of statinsQ24647863
Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARγ2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell culturesQ30311909
The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis.Q30471296
Current perspectives on statinsQ33818381
Local simvastatin effects on mandibular bone growth and inflammationQ34311906
Clinical review 145: Pleiotropic effects of statins: lipid reduction and beyondQ34587210
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitroQ34793691
Treatment of intrabony periodontal defects with enamel matrix derivative: a literature reviewQ35024507
Role of prostaglandin pathway and alendronate-based carriers to enhance statin-induced boneQ35141393
The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic reviewQ35670368
Cyclooxygenase-2 inhibitor reduces simvastatin-induced bone morphogenetic protein-2 and bone formation in vivoQ36054538
Statins and bone metabolismQ36395695
Periodontal disease and systemic conditions: a bidirectional relationship.Q36602669
Statin use is associated with fewer periodontal lesions: A retrospective studyQ36688456
Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activationQ36882289
Evaluation of anti-inflammatory effect of statins in chronic periodontitis.Q37133316
Periodontitis: a polymicrobial disruption of host homeostasisQ37761827
Global periodontal disease epidemiologyQ37963578
Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect ModifiersQ39731733
The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in ratsQ39809358
Effect of atorvastatin on chronic periodontitis: a randomized pilot studyQ39949599
Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar ratsQ39965141
Simvastatin decreases IL-6 and IL-8 production in epithelial cellsQ40275606
Induction of osteoblast differentiation indices by statins in MC3T3-E1 cellsQ40508839
Stimulation of bone formation in vitro and in rodents by statinsQ40914337
The effect of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced diseaseQ41065120
Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP ratsQ41084727
Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differencesQ41478162
Periodontal status and hyperlipidemia: statin users versus non-usersQ42642433
Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trialQ43164031
Dual effect of statin medication on the periodontiumQ43237596
Effect of statins on bone mineral density and bone histomorphometry in rodentsQ43764601
Guided tissue regeneration may modulate gene expression in periodontal intrabony defects: a human studyQ43947029
Tooth loss, periodontitis, and statins in a population-based follow-up studyQ44012981
Efficacy of subgingivally delivered simvastatin in the treatment of patients with type 2 diabetes and chronic periodontitis: a randomized double-masked controlled clinical trialQ44159476
Comparison of CCL28, interleukin-8, interleukin-1β and tumor necrosis factor-alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitisQ44366647
Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophagesQ44381124
Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cellsQ44546791
High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins.Q44804684
[Pleiotropic effects of statins].Q46390886
Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical studyQ46405118
Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cellsQ46563393
Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts.Q46694358
Prevalence of periodontitis in adults in the United States: 2009 and 2010.Q47203547
Simvastatin application to augment facial jaw bone in a dog model: pilot studyQ48537410
Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment.Q51364264
Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemiaQ51387165
High glucose-boosted inflammatory responses to lipopolysaccharide are suppressed by statin.Q53578309
Effect of Simvastatin Administration on Periodontitis-Associated Bone Loss in Ovariectomized RatsQ60841848
Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational StudyQ73666505
EXPERIMENTAL GINGIVITIS IN MANQ78377033
Host responses in periodontal diseases: a previewQ79533228
Are statins associated with decreased tooth loss in chronic periodontitis?Q79672432
Locally applied simvastatin promotes fracture healing in ovariectomized ratQ80593328
Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defectQ80847311
The effect of simvastatin on remodelling of the alveolar bone following tooth extractionQ81096865
Injectable simvastatin in periodontal defects and alveolar ridges: pilot studiesQ81730136
Early alveolar bone regeneration in rats after topical administration of simvastatinQ83076900
Effect of simvastatin on the osteogenetic behavior of alveolar osteoblasts and periodontal ligament cellsQ83593886
How do statins work?: changing paradigms with implications for statin allocationQ86038019
Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathwayQ87258349
Clinical efficacy of subgingivally delivered 1.2% atorvastatin in chronic periodontitis: a randomized controlled clinical trialQ87403401
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpleiotropyQ1134884
systematic reviewQ1504425
periodontitisQ520127
P304page(s)877-885
P577publication date2015-06-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titlePleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review
P478volume79

Reverse relations

cites work (P2860)
Q99566058"Effect of local application of simvastatin in bone regeneration of peri-apical defects-a clinico-radiographic study
Q35896394Aterofisiol(®) in carotid plaque evolution
Q64096419Contribution of Statins towards Periodontal Treatment: A Review
Q64119852Critical Appraisal of Bidirectional Relationship between Periodontitis and Hyperlipidemia
Q48130000Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta-analysis.
Q96137322Periodontitis and Cardiovascular Diseases. Consensus Report
Q89499608Periodontitis and cardiovascular diseases: Consensus report
Q48134962Simvastatin exerts antiproliferative and differentiating effects on MG63 osteoblast-like cells: Morphological and immunocytochemical study
Q36984463Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis
Q48168019Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta-analysis of preclinical in vivo trials
Q38987341The Effect of Locally Delivered Statins on Treating Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis
Q49357023The effect of statins on periodontal treatment-a systematic review with meta-analyses and meta-regression
Q91607022The effects of statins on dental and oral health: a review of preclinical and clinical studies
Q46966713Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure

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