| scholarly article | Q13442814 |
| P2093 | author name string | Gary E Landreth | |
| Jonathan D Smith | |||
| C Y Daniel Lee | |||
| Wayne Tse | |||
| P2860 | cites work | ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein | Q40811937 |
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| Cellular cholesterol efflux mediated by cyclodextrins. Demonstration Of kinetic pools and mechanism of efflux. | Q41186178 | ||
| Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease | Q41428334 | ||
| Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet | Q42054024 | ||
| Solvent effects on self-assembly of beta-amyloid peptide | Q42122726 | ||
| The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis | Q42126660 | ||
| Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide | Q43664811 | ||
| Statin therapy for Alzheimer's disease: will it work? | Q44125950 | ||
| Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet | Q44243543 | ||
| Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway | Q44300047 | ||
| High-yield isolation of murine microglia by mild trypsinization. | Q44645887 | ||
| Oral D-4F causes formation of pre-beta high-density lipoprotein and improves high-density lipoprotein-mediated cholesterol efflux and reverse cholesterol transport from macrophages in apolipoprotein E-null mice | Q44936573 | ||
| ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. | Q44989710 | ||
| Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. | Q45992629 | ||
| Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. | Q45993868 | ||
| A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1. | Q46662303 | ||
| The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. | Q46738144 | ||
| Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice | Q46738149 | ||
| A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization. | Q47717695 | ||
| The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease | Q48254282 | ||
| Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease | Q48795523 | ||
| Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains | Q49112901 | ||
| Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. | Q52271466 | ||
| Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid | Q70687889 | ||
| Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides | Q71727345 | ||
| Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid | Q72167723 | ||
| Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture | Q73491113 | ||
| An apolipoprotein A-I mimetic works best in the presence of apolipoprotein A-I | Q81527176 | ||
| Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease | Q22248076 | ||
| Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity | Q24291110 | ||
| Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP | Q24297496 | ||
| Identification of the switch in early-to-late endosome transition | Q24309112 | ||
| Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake | Q24322000 | ||
| Intracellular cholesterol transport | Q24553317 | ||
| Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells | Q24628984 | ||
| ApoE promotes the proteolytic degradation of Abeta | Q24651102 | ||
| Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families | Q27860677 | ||
| Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition | Q28143799 | ||
| Apolipoprotein E: far more than a lipid transport protein | Q28204471 | ||
| Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease | Q28238269 | ||
| Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid | Q28279517 | ||
| The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease | Q28294536 | ||
| Apolipoprotein E: cholesterol transport protein with expanding role in cell biology | Q28294791 | ||
| Isoform-specific binding of apolipoprotein E to beta-amyloid | Q28596589 | ||
| Automatic and quantitative measurement of protein-protein colocalization in live cells. | Q29616276 | ||
| Decreased clearance of CNS beta-amyloid in Alzheimer's disease | Q29616534 | ||
| The diversity of Rab proteins in vesicle transport | Q29620216 | ||
| Rab GTPases: specifying and deciphering organelle identity and function | Q29620750 | ||
| Cholesterol level regulates endosome motility via Rab proteins. | Q30481108 | ||
| The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex | Q32138894 | ||
| PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. | Q33897102 | ||
| Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice | Q33906674 | ||
| Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model | Q33915820 | ||
| Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium | Q33946762 | ||
| Sterol and lipid trafficking in mammalian cells | Q33995960 | ||
| Late endosome motility depends on lipids via the small GTPase Rab7. | Q34078419 | ||
| A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease | Q34094305 | ||
| Rab GTPases, intracellular traffic and disease. | Q34109808 | ||
| The endocytic pathway: a mosaic of domains | Q34389525 | ||
| Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis | Q34554154 | ||
| Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events | Q34578165 | ||
| The role of apolipoprotein E in Alzheimer's disease | Q34603092 | ||
| Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease | Q34662682 | ||
| Regulation of amyloid beta-peptide levels by enzymatic degradation. | Q35006810 | ||
| A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. | Q35103136 | ||
| Cholesterol homeostasis and function in neurons of the central nervous system | Q35178066 | ||
| Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease | Q35261597 | ||
| Human apoE isoforms differentially regulate brain amyloid-β peptide clearance | Q35334161 | ||
| High density lipoprotein structure-function and role in reverse cholesterol transport | Q35547011 | ||
| Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases | Q35579635 | ||
| The roles of ubiquitin and lipids in protein sorting along the endocytic pathway | Q35639592 | ||
| Lipids as targeting signals: lipid rafts and intracellular trafficking. | Q35696773 | ||
| In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology | Q35794586 | ||
| Lipid and cholesterol trafficking in NPC. | Q35909553 | ||
| Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis | Q35918384 | ||
| Targeting Rab GTPases to distinct membrane compartments | Q35936418 | ||
| Apolipoprotein A-I mimetic peptides | Q36098714 | ||
| Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. | Q36383616 | ||
| Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment | Q36407043 | ||
| Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease | Q36604545 | ||
| Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning | Q37267618 | ||
| Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease | Q37668534 | ||
| Sterol binding by OSBP-related protein 1L regulates late endosome motility and function | Q39670499 | ||
| Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. | Q40496060 | ||
| Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycans. | Q40670478 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | microglia | Q1622829 |
| P304 | page(s) | 2032-2044 | |
| P577 | publication date | 2011-11-30 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels | |
| P478 | volume | 287 |
| Q37635614 | A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease |
| Q42689665 | A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects |
| Q48092039 | A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain |
| Q36713957 | ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease. |
| Q38216169 | ABCA7 in Alzheimer's Disease |
| Q36594552 | APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. |
| Q37078850 | APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease. |
| Q36822983 | Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice |
| Q37214684 | Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression |
| Q35025065 | Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation |
| Q34048670 | Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector |
| Q36996975 | Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta |
| Q28085139 | Alzheimer's disease: Unique markers for diagnosis & new treatment modalities |
| Q36764094 | Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease |
| Q42026180 | Amyloid-β sequester proteins as blood-based biomarkers of cognitive decline |
| Q37714716 | Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response. |
| Q92702136 | Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity |
| Q92322562 | Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies |
| Q39155261 | Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins |
| Q60310866 | Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages |
| Q38197948 | Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease |
| Q36424857 | Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease |
| Q24321663 | Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro |
| Q38668230 | Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study |
| Q33853002 | Associations between serum cholesterol levels and cerebral amyloidosis |
| Q62669742 | Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion |
| Q36065117 | Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice |
| Q89744056 | Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease |
| Q89388307 | Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer's Disease |
| Q38776867 | Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures |
| Q27009984 | Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases |
| Q40496349 | Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75. |
| Q50531818 | Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. |
| Q33826820 | Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking |
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| Q60921223 | Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor |
| Q33830137 | Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. |
| Q30683859 | Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. |
| Q46330948 | Imaging regiospecific lipid turnover in mouse brain with desorption electrospray ionization mass spectrometry |
| Q35137114 | Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist |
| Q57816569 | Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease |
| Q34383525 | Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance |
| Q34622157 | Insulin resistance in Alzheimer's disease |
| Q28394967 | Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors |
| Q37179244 | LXR Regulation of Brain Cholesterol: From Development to Disease |
| Q30436205 | Mechanisms of U87 astrocytoma cell uptake and trafficking of monomeric versus protofibril Alzheimer's disease amyloid-β proteins |
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| Q52804356 | Rab GTPases and Membrane Trafficking in Neurodegeneration. |
| Q39130182 | Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy. |
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