The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways.

scientific article published on January 2012

The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CHOM.2011.12.003
P932PMC publication ID3266558
P698PubMed publication ID22264513
P5875ResearchGate publication ID221765864

P50authorMatthew A. MulveyQ55979450
P2093author name stringBijaya K Dhakal
P2860cites workEffect of Escherichia coli alpha-hemolysin on human peripheral leukocyte function in vitroQ24627507
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Contribution of Escherichia coli alpha-hemolysin to bacterial virulence and to intraperitoneal alterations in peritonitisQ30304556
Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysisQ30486501
Listeria monocytogenes transiently alters mitochondrial dynamics during infectionQ30498309
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladderQ30540440
Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiationQ30893901
Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentationQ30903480
In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitorsQ33184357
Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coliQ33290835
Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.Q33375026
Use of zebrafish to probe the divergent virulence potentials and toxin requirements of extraintestinal pathogenic Escherichia coliQ33519502
Cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanismQ33592569
Persistence of uropathogenic Escherichia coli in the face of multiple antibioticsQ33826366
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coliQ33883358
Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection.Q34008358
Caspases - an updateQ34012617
Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells.Q34300908
RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin.Q34673172
Attenuation of human neutrophil migration and function by uropathogenic bacteria.Q34975465
Covert operations of uropathogenic Escherichia coli within the urinary tractQ35966152
Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destructionQ36200333
Escherichia coli mediated urinary tract infections: are there distinct uropathogenic E. coli (UPEC) pathotypes?Q36258460
Modulation of host innate immune response in the bladder by uropathogenic Escherichia coliQ36313895
Effect of Escherichia coli alpha-hemolysin on human peripheral leukocyte viability in vitro.Q36440663
Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxinsQ36536668
Pore-forming toxins and cellular non-immune defenses (CNIDs).Q36711858
Hemolysin of uropathogenic Escherichia coli evokes extensive shedding of the uroepithelium and hemorrhage in bladder tissue within the first 24 hours after intraurethral inoculation of mice.Q36747117
The emerging role of serine proteases in apoptosisQ36826016
Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritisQ36974898
Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strainsQ36980944
Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway.Q37029864
Escherichia coli alpha-hemolysin: characteristics and probable role in pathogenicityQ37066599
Serine peptidases: classification, structure and functionQ37079798
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infectionQ37227229
Role of MAPK p38 in the cellular responses to pore-forming toxins.Q37769785
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coliQ38293889
The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytesQ38346172
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancerQ38361640
Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.Q39523324
Pore-forming toxins induce multiple cellular responses promoting survival.Q39553466
Association of RTX toxins with erythrocytesQ39826559
Uropathogenic Escherichia coli dominantly suppress the innate immune response of bladder epithelial cells by a lipopolysaccharide- and Toll-like receptor 4-independent pathwayQ40016803
Escherichia coli hemolysin may damage target cell membranes by generating transmembrane poresQ40171498
Cytocidal effects of Escherichia coli hemolysin on human T lymphocytesQ40266825
Why Escherichia coli alpha-hemolysin induces calcium oscillations in mammalian cells--the pore is on its own.Q40295280
Actin-gated intracellular growth and resurgence of uropathogenic Escherichia coli.Q40302030
Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calciumQ40926236
Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriaeQ41476453
Relevance of fatty acid covalently bound to Escherichia coli alpha-hemolysin and membrane microdomains in the oligomerization processQ42576844
Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin ActivationQ42919010
CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasionQ44220432
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
Role of alpha-hemolysin for the in vitro phagocytosis and intracellular killing of Escherichia coli.Q46022864
E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia modelQ46417447
Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytesQ47859943
Escherichia coli alpha-haemolysin induces focal leaks in colonic epithelium: a novel mechanism of bacterial translocation.Q52925469
Carbon monoxide prevents apoptosis induced by uropathogenic Escherichia coli toxins.Q54472830
Intracellular bacterial biofilm-like pods in urinary tract infections.Q54522305
Interaction of the bacterial protein toxin alpha-haemolysin with model membranes: protein binding does not always lead to lytic activity.Q54604025
Haemolysin contributes to virulence of extra-intestinal E. coli infectionsQ59085495
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coliQ64449884
Calcium-dependent conformation of E. coli alpha-haemolysin. Implications for the mechanism of membrane insertion and lysisQ74158025
P433issue1
P921main subjectproteolysisQ33123
cell adhesionQ187640
P304page(s)58-69
P577publication date2012-01-01
P1433published inCell Host & MicrobeQ5058153
P1476titleThe UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways
P478volume11

Reverse relations

cites work (P2860)
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